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Dennd1a DENN/MADD domain containing 1A [ Mus musculus (house mouse) ]

Gene ID: 227801, updated on 23-Jun-2021

Summary

Official Symbol
Dennd1aprovided by MGI
Official Full Name
DENN/MADD domain containing 1Aprovided by MGI
Primary source
MGI:MGI:2442794
See related
Ensembl:ENSMUSG00000035392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
connecdenn; 6030446I19Rik
Expression
Ubiquitous expression in kidney adult (RPKM 10.2), adrenal adult (RPKM 9.6) and 28 other tissues See more
Orthologs
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Genomic context

See Dennd1a in Genome Data Viewer
Location:
2; 2 B
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37689002..38177417, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37798990..38287410, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (37654510..38142904, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene zinc finger protein 609 pseudogene Neighboring gene microRNA 5128 Neighboring gene crumbs family member 2 Neighboring gene predicted gene, 46736 Neighboring gene predicted gene 27197 Neighboring gene LIM homeobox protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC38995

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Rab protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DENN domain-containing protein 1A
Names
connecdenn 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362973.1NP_001349902.1  DENN domain-containing protein 1A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL805959, AL928810, AL929186, AL929238
    Conserved Domains (4) summary
    smart00801
    Location:305371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:991
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl26464
    Location:6921018
    Atrophin-1; Atrophin-1 family
  2. NM_001362977.1NP_001349906.1  DENN domain-containing protein 1A isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AK137530, AL805959, AL929186
    Conserved Domains (4) summary
    smart00801
    Location:273339
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:63241
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:2659
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl26464
    Location:617943
    Atrophin-1; Atrophin-1 family
  3. NM_001362978.1NP_001349907.1  DENN domain-containing protein 1A isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL805959, AL928810, AL929186, AL929238
    Conserved Domains (3) summary
    smart00801
    Location:233299
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:27201
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl26464
    Location:577903
    Atrophin-1; Atrophin-1 family
  4. NM_146122.3NP_666234.3  DENN domain-containing protein 1A isoform 2

    See identical proteins and their annotated locations for NP_666234.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK137530, AL805959, AL929186, BQ444119, CX563166
    Consensus CDS
    CCDS16007.1
    UniProtKB/Swiss-Prot
    Q8K382
    Related
    ENSMUSP00000099848.4, ENSMUST00000102787.10
    Conserved Domains (3) summary
    smart00801
    Location:305371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:991
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    37689002..38177417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250097.2XP_030105957.1  DENN domain-containing protein 1A isoform X18

    Conserved Domains (2) summary
    smart00801
    Location:46112
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:390716
    PHA03247; large tegument protein UL36; Provisional
  2. XM_036160931.1XP_036016824.1  DENN domain-containing protein 1A isoform X14

    Conserved Domains (3) summary
    smart00801
    Location:122188
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:190
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:509835
    PHA03247; large tegument protein UL36; Provisional
  3. XM_036160935.1XP_036016828.1  DENN domain-containing protein 1A isoform X14

    Conserved Domains (3) summary
    smart00801
    Location:122188
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:190
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:509835
    PHA03247; large tegument protein UL36; Provisional
  4. XM_036160936.1XP_036016829.1  DENN domain-containing protein 1A isoform X15

    Conserved Domains (3) summary
    smart00801
    Location:122188
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:190
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:466792
    PHA03247; large tegument protein UL36; Provisional
  5. XM_036160933.1XP_036016826.1  DENN domain-containing protein 1A isoform X14

    Conserved Domains (3) summary
    smart00801
    Location:122188
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:190
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:509835
    PHA03247; large tegument protein UL36; Provisional
  6. XM_036160934.1XP_036016827.1  DENN domain-containing protein 1A isoform X14

    Conserved Domains (3) summary
    smart00801
    Location:122188
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:190
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:509835
    PHA03247; large tegument protein UL36; Provisional
  7. XM_006498003.4XP_006498066.1  DENN domain-containing protein 1A isoform X5

    Conserved Domains (4) summary
    smart00801
    Location:305371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:991
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:668994
    PHA03247; large tegument protein UL36; Provisional
  8. XM_006497998.5XP_006498061.1  DENN domain-containing protein 1A isoform X1

    Conserved Domains (4) summary
    smart00801
    Location:305371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:991
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:7111037
    PHA03247; large tegument protein UL36; Provisional
  9. XM_030250063.1XP_030105923.1  DENN domain-containing protein 1A isoform X7

    Conserved Domains (4) summary
    smart00801
    Location:275341
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:65243
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:1461
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:662988
    PHA03247; large tegument protein UL36; Provisional
  10. XM_006498001.4XP_006498064.1  DENN domain-containing protein 1A isoform X3

    Conserved Domains (4) summary
    smart00801
    Location:275341
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:65243
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:1461
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:6811007
    PHA03247; large tegument protein UL36; Provisional
  11. XM_030250065.1XP_030105925.1  DENN domain-containing protein 1A isoform X12

    Conserved Domains (3) summary
    smart00801
    Location:233299
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:27201
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:620946
    PHA03247; large tegument protein UL36; Provisional
  12. XM_011239087.2XP_011237389.1  DENN domain-containing protein 1A isoform X10

    Conserved Domains (3) summary
    smart00801
    Location:233299
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:27201
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:639965
    PHA03247; large tegument protein UL36; Provisional
  13. XM_036160916.1XP_036016809.1  DENN domain-containing protein 1A isoform X8

    Conserved Domains (4) summary
    smart00801
    Location:273339
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:63241
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:660986
    PHA03247; large tegument protein UL36; Provisional
    cl04085
    Location:2659
    uDENN; uDENN domain
  14. XM_006498002.4XP_006498065.1  DENN domain-containing protein 1A isoform X4

    Conserved Domains (4) summary
    smart00801
    Location:273339
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:63241
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:2659
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:6791005
    PHA03247; large tegument protein UL36; Provisional
  15. XM_036160920.1XP_036016813.1  DENN domain-containing protein 1A isoform X11

    Conserved Domains (4) summary
    smart00801
    Location:278344
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95246
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:991
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:622948
    PHA03247; large tegument protein UL36; Provisional
  16. XM_036160912.1XP_036016805.1  DENN domain-containing protein 1A isoform X6

    Conserved Domains (4) summary
    smart00801
    Location:278344
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95246
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:991
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:665991
    PHA03247; large tegument protein UL36; Provisional
  17. XM_006498000.4XP_006498063.1  DENN domain-containing protein 1A isoform X2

    Conserved Domains (4) summary
    smart00801
    Location:278344
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95246
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:991
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:6841010
    PHA03247; large tegument protein UL36; Provisional
  18. XM_030250090.2XP_030105950.1  DENN domain-containing protein 1A isoform X17

    Conserved Domains (2) summary
    smart00801
    Location:46112
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:433759
    PHA03247; large tegument protein UL36; Provisional
  19. XM_030250087.2XP_030105947.1  DENN domain-containing protein 1A isoform X16

    Conserved Domains (2) summary
    smart00801
    Location:46112
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:452778
    PHA03247; large tegument protein UL36; Provisional
  20. XM_030250088.2XP_030105948.1  DENN domain-containing protein 1A isoform X16

    Conserved Domains (2) summary
    smart00801
    Location:46112
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:452778
    PHA03247; large tegument protein UL36; Provisional
  21. XM_030250071.1XP_030105931.1  DENN domain-containing protein 1A isoform X13

    Conserved Domains (3) summary
    smart00801
    Location:122188
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:190
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    PHA03247
    Location:528854
    PHA03247; large tegument protein UL36; Provisional
  22. XM_006498004.1XP_006498067.1  DENN domain-containing protein 1A isoform X9

    Conserved Domains (4) summary
    smart00801
    Location:306372
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:96274
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:1092
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:650976
    PHA03247; large tegument protein UL36; Provisional
  23. XM_036160937.1XP_036016830.1  DENN domain-containing protein 1A isoform X16

    Conserved Domains (2) summary
    smart00801
    Location:46112
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:452778
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_004939812.1 RNA Sequence

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