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Rhbdf2 rhomboid 5 homolog 2 [ Mus musculus (house mouse) ]

Gene ID: 217344, updated on 12-Oct-2021

Summary

Official Symbol
Rhbdf2provided by MGI
Official Full Name
rhomboid 5 homolog 2provided by MGI
Primary source
MGI:MGI:2442473
See related
Ensembl:ENSMUSG00000020806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cub; iRh; Rhbd; Rhbdl6; 4732465I17Rik
Expression
Broad expression in ovary adult (RPKM 35.3), spleen adult (RPKM 33.7) and 21 other tissues See more
Orthologs
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Genomic context

See Rhbdf2 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116488974..116517786, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116598148..116626960, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (116459479..116488333, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sphingosine kinase 1 Neighboring gene ubiquitin-conjugating enzyme E2O Neighboring gene arylalkylamine N-acetyltransferase Neighboring gene cytoglobin Neighboring gene photoreceptor disc component Neighboring gene small nucleolar RNA, C/D box 1C Neighboring gene small nucleolar RNA host gene 16

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inactive rhomboid protein 2
Names
iRhom2
rhomboid family member 2
rhomboid veinlet-like protein 6
rhomboid, veinlet-like 6
rhomboid-like protein 6
rhomboid-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167680.2NP_001161152.1  inactive rhomboid protein 2

    See identical proteins and their annotated locations for NP_001161152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL607039
    Consensus CDS
    CCDS25672.1
    UniProtKB/Swiss-Prot
    Q80WQ6
    Related
    ENSMUSP00000099318.4, ENSMUST00000103029.10
    Conserved Domains (3) summary
    pfam01694
    Location:619760
    Rhomboid; Rhomboid family
    pfam12595
    Location:98304
    Rhomboid_SP; Rhomboid serine protease
    cl19823
    Location:719803
    GtrA; GtrA-like protein
  2. NM_172572.4NP_766160.2  inactive rhomboid protein 2

    See identical proteins and their annotated locations for NP_766160.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL607039
    Consensus CDS
    CCDS25672.1
    UniProtKB/Swiss-Prot
    Q80WQ6
    Related
    ENSMUSP00000099317.2, ENSMUST00000103028.8
    Conserved Domains (3) summary
    pfam01694
    Location:619760
    Rhomboid; Rhomboid family
    pfam12595
    Location:98304
    Rhomboid_SP; Rhomboid serine protease
    cl19823
    Location:719803
    GtrA; GtrA-like protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116488974..116517786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245904.2XP_030101764.1  inactive rhomboid protein 2 isoform X2

    Conserved Domains (1) summary
    pfam12595
    Location:98328
    Rhomboid_SP; Rhomboid serine protease
  2. XM_006533108.5XP_006533171.1  inactive rhomboid protein 2 isoform X3

    Conserved Domains (1) summary
    pfam12595
    Location:98302
    Rhomboid_SP; Rhomboid serine protease
  3. XM_030245903.2XP_030101763.1  inactive rhomboid protein 2 isoform X1

    Conserved Domains (3) summary
    pfam01694
    Location:648788
    Rhomboid; Rhomboid family
    pfam12595
    Location:98328
    Rhomboid_SP; Rhomboid serine protease
    cl28910
    Location:746836
    MFS; Major Facilitator Superfamily
  4. XM_017314494.3XP_017169983.1  inactive rhomboid protein 2 isoform X4

    Conserved Domains (3) summary
    pfam01694
    Location:392532
    Rhomboid; Rhomboid family
    pfam12595
    Location:3772
    Rhomboid_SP; Rhomboid serine protease
    cl28910
    Location:517574
    MFS; Major Facilitator Superfamily
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