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Plk4 polo like kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 20873, updated on 23-Jun-2021

Summary

Official Symbol
Plk4provided by MGI
Official Full Name
polo like kinase 4provided by MGI
Primary source
MGI:MGI:101783
See related
Ensembl:ENSMUSG00000025758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S; Sak; Stk1; Stk18; AI385771; 1700028H20
Summary
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 9.6) and 16 other tissues See more
Orthologs
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Genomic context

See Plk4 in Genome Data Viewer
Location:
3; 3 B
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (40754386..40771318)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (40799951..40816883)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (40603873..40620805)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Neighboring gene heat shock protein 4 like Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene predicted gene 2011 Neighboring gene FUN14 domain containing 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in deuterosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PLK4
Names
PLK-4
serine/threonine kinase 18
serine/threonine-protein kinase 18
serine/threonine-protein kinase Sak
NP_035625.2
NP_775261.2
XP_006500831.1
XP_006500833.1
XP_030108378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011495.2NP_035625.2  serine/threonine-protein kinase PLK4 isoform 1

    See identical proteins and their annotated locations for NP_035625.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC146980, AK137471, BC051483
    Consensus CDS
    CCDS17328.1
    UniProtKB/Swiss-Prot
    Q64702
    Related
    ENSMUSP00000026858.6, ENSMUST00000026858.11
    Conserved Domains (5) summary
    smart00220
    Location:12265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:548659
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:660768
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:839918
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd14186
    Location:10265
    STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
  2. NM_173169.2NP_775261.2  serine/threonine-protein kinase PLK4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC160757, AK137471, BC051483
    Consensus CDS
    CCDS57210.1
    UniProtKB/Swiss-Prot
    Q64702
    Related
    ENSMUSP00000145277.2, ENSMUST00000203295.3
    Conserved Domains (5) summary
    smart00220
    Location:12265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:548632
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:633741
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:812891
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd14186
    Location:10265
    STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

RNA

  1. NR_045576.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. The resulting transcript has a short orf with a strong Kozak signal that renders this transcript a nonsense-mediated mRNA decay (NMD) candidate. Therefore, this transcript is thought to be non-protein coding.
    Source sequence(s)
    AC160757, AK164465, BC051483
    Related
    ENSMUST00000203895.3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    40754386..40771318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500770.5XP_006500833.1  serine/threonine-protein kinase PLK4 isoform X2

    Conserved Domains (3) summary
    cd13114
    Location:122233
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:234342
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:413492
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
  2. XM_006500768.4XP_006500831.1  serine/threonine-protein kinase PLK4 isoform X1

    See identical proteins and their annotated locations for XP_006500831.1

    Conserved Domains (4) summary
    cd13114
    Location:549660
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:661769
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:840919
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd14186
    Location:11266
    STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
  3. XM_030252518.2XP_030108378.1  serine/threonine-protein kinase PLK4 isoform X2

    Conserved Domains (3) summary
    cd13114
    Location:122233
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:234342
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:413492
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
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