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ERBB2 erb-b2 receptor tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 2064, updated on 28-Nov-2021

Summary

Official Symbol
ERBB2provided by HGNC
Official Full Name
erb-b2 receptor tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:3430
See related
Ensembl:ENSG00000141736 MIM:164870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; HER-2/neu
Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 34.7), skin (RPKM 30.2) and 24 other tissues See more
Orthologs
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Genomic context

See ERBB2 in Genome Data Viewer
Location:
17q12
Exon count:
35
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (39688094..39728660)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37844347..37884911)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1769 Neighboring gene phenylethanolamine N-methyltransferase Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene microRNA 4728 Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7 Neighboring gene IKAROS family zinc finger 3 Neighboring gene keratin 8 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cetuximab response
MedGen: CN077967 GeneReviews: Not available
Compare labs
Glioma susceptibility 1
MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
Compare labs
Lung cancer
MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
Compare labs
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs
Panitumumab response
MedGen: CN077999 GeneReviews: Not available
Compare labs
Pertuzumab response
MedGen: CN233145 GeneReviews: Not available
not available
Stomach cancer
MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
Compare labs
Trastuzumab response
MedGen: CN078025 GeneReviews: Not available
Compare labs
VISCERAL NEUROPATHY, FAMILIAL, 2, AUTOSOMAL RECESSIVE
MedGen: CN300314 OMIM: 619465 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ErbB-3 class receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase I core binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in enzyme linked receptor protein signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of immature T cell proliferation in thymus IEA
Inferred from Electronic Annotation
more info
 
involved_in neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of microtubule-based process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of ERBB3:ERBB2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in myelin sheath IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
c-erb B2/neu protein
herstatin
human epidermal growth factor receptor 2
metastatic lymph node gene 19 protein
neuro/glioblastoma derived oncogene homolog
neuroblastoma/glioblastoma derived oncogene homolog
proto-oncogene Neu
proto-oncogene c-ErbB-2
tyrosine kinase-type cell surface receptor HER2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_001005862.1
NP_001276865.1
NP_001276866.1
NP_001276867.1
NP_001369711.1
NP_001369712.1
NP_001369713.1
NP_001369714.1
NP_001369715.1
NP_001369716.1
NP_001369717.1
NP_001369718.1
NP_001369719.1
NP_001369720.1
NP_001369721.1
NP_001369722.1
NP_001369723.1
NP_001369724.1
NP_001369725.1
NP_001369726.1
NP_001369727.1
NP_001369728.1
NP_001369729.1
NP_001369730.1
NP_001369731.1
NP_001369732.1
NP_001369733.1
NP_001369734.1
NP_001369735.1
NP_004439.2
XP_024306409.1
XP_024306410.1
XP_024306411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007503.1 RefSeqGene

    Range
    4945..45523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_724

mRNA and Protein(s)

  1. NM_001005862.3NP_001005862.1  receptor tyrosine-protein kinase erbB-2 isoform b

    See identical proteins and their annotated locations for NP_001005862.1

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Consensus CDS
    CCDS45667.1
    UniProtKB/Swiss-Prot
    P04626
    Related
    ENSP00000462438.1, ENST00000584601.5
    Conserved Domains (5) summary
    cd12094
    Location:611654
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:682960
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481613
    GF_recep_IV; Growth factor receptor domain IV
  2. NM_001289936.2NP_001276865.1  receptor tyrosine-protein kinase erbB-2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Consensus CDS
    CCDS74052.1
    UniProtKB/Swiss-Prot
    P04626
    Related
    ENSP00000446466.1, ENST00000541774.5
    Conserved Domains (8) summary
    cd12094
    Location:626669
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:542588
    FU; Furin-like repeats
    cd00064
    Location:220265
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:697975
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:174323
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:37158
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:705961
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:496628
    GF_recep_IV; Growth factor receptor domain IV
  3. NM_001289937.2NP_001276866.1  receptor tyrosine-protein kinase erbB-2 isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Consensus CDS
    CCDS77016.1
    UniProtKB/TrEMBL
    J3QLU9
    Related
    ENSP00000463714.1, ENST00000584450.5
    Conserved Domains (8) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:557603
    FU; Furin-like repeats
    cd00064
    Location:235280
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:712990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:720976
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
  4. NM_001289938.2NP_001276867.1  receptor tyrosine-protein kinase erbB-2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC087491
    Consensus CDS
    CCDS77017.1
    UniProtKB/Swiss-Prot
    P04626
    UniProtKB/TrEMBL
    F5H1T4
    Related
    ENSP00000462808.1, ENST00000578199.5
    Conserved Domains (5) summary
    smart00261
    Location:527573
    FU; Furin-like repeats
    cd00064
    Location:205250
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:159308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481603
    GF_recep_IV; Growth factor receptor domain IV
  5. NM_001382782.1NP_001369711.1  receptor tyrosine-protein kinase erbB-2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:611654
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:682960
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481613
    GF_recep_IV; Growth factor receptor domain IV
  6. NM_001382783.1NP_001369712.1  receptor tyrosine-protein kinase erbB-2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:611654
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:682960
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481613
    GF_recep_IV; Growth factor receptor domain IV
  7. NM_001382784.1NP_001369713.1  receptor tyrosine-protein kinase erbB-2 isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:680723
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:7511029
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:550682
    GF_recep_IV; Growth factor receptor domain IV
  8. NM_001382785.1NP_001369714.1  receptor tyrosine-protein kinase erbB-2 isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:675718
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:7461024
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511677
    GF_recep_IV; Growth factor receptor domain IV
  9. NM_001382786.1NP_001369715.1  receptor tyrosine-protein kinase erbB-2 isoform h precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:680723
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:10901219
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:550682
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:7511017
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001382787.1NP_001369716.1  receptor tyrosine-protein kinase erbB-2 isoform i precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:666709
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:7371015
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:214363
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52198
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:536668
    GF_recep_IV; Growth factor receptor domain IV
  11. NM_001382788.1NP_001369717.1  receptor tyrosine-protein kinase erbB-2 isoform j precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:651694
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:7221000
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:521653
    GF_recep_IV; Growth factor receptor domain IV
  12. NM_001382789.1NP_001369718.1  receptor tyrosine-protein kinase erbB-2 isoform k precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:648691
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:719997
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:518650
    GF_recep_IV; Growth factor receptor domain IV
  13. NM_001382790.1NP_001369719.1  receptor tyrosine-protein kinase erbB-2 isoform l precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:640683
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:711989
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511642
    GF_recep_IV; Growth factor receptor domain IV
  14. NM_001382791.1NP_001369720.1  receptor tyrosine-protein kinase erbB-2 isoform m precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:638681
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:709987
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:186335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52170
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:508640
    GF_recep_IV; Growth factor receptor domain IV
  15. NM_001382792.1NP_001369721.1  receptor tyrosine-protein kinase erbB-2 isoform n precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:10511180
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712978
    PKc_like; Protein Kinases, catalytic domain
  16. NM_001382793.1NP_001369722.1  receptor tyrosine-protein kinase erbB-2 isoform o precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:10491178
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712976
    PKc_like; Protein Kinases, catalytic domain
  17. NM_001382794.1NP_001369723.1  receptor tyrosine-protein kinase erbB-2 isoform p precorsor precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:698976
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
  18. NM_001382795.1NP_001369724.1  receptor tyrosine-protein kinase erbB-2 isoform q precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (4) summary
    cd05109
    Location:696974
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511633
    GF_recep_IV; Growth factor receptor domain IV
  19. NM_001382796.1NP_001369725.1  receptor tyrosine-protein kinase erbB-2 isoform r precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:712990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
  20. NM_001382797.1NP_001369726.1  receptor tyrosine-protein kinase erbB-2 isoform s precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:10301159
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712957
    PKc_like; Protein Kinases, catalytic domain
  21. NM_001382798.1NP_001369727.1  receptor tyrosine-protein kinase erbB-2 isoform t precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:10111140
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712938
    PKc_like; Protein Kinases, catalytic domain
  22. NM_001382799.1NP_001369728.1  receptor tyrosine-protein kinase erbB-2 isoform u precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:581624
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:652930
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:148278
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52147
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:451583
    GF_recep_IV; Growth factor receptor domain IV
  23. NM_001382800.1NP_001369729.1  receptor tyrosine-protein kinase erbB-2 isoform v precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:10011130
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712928
    PKc_like; Protein Kinases, catalytic domain
  24. NM_001382801.1NP_001369730.1  receptor tyrosine-protein kinase erbB-2 isoform w precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    COG3170
    Location:9951124
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511633
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:696922
    PKc_like; Protein Kinases, catalytic domain
  25. NM_001382802.1NP_001369731.1  receptor tyrosine-protein kinase erbB-2 isoform x precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:555598
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:626904
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:201252
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:425557
    GF_recep_IV; Growth factor receptor domain IV
  26. NM_001382803.1NP_001369732.1  receptor tyrosine-protein kinase erbB-2 isoform y precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712976
    PKc_like; Protein Kinases, catalytic domain
  27. NM_001382804.1NP_001369733.1  receptor tyrosine-protein kinase erbB-2 isoform z precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Related
    ENSP00000404047.2, ENST00000445658.6
    Conserved Domains (5) summary
    cd12094
    Location:365408
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:436714
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:2562
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:90206
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:235367
    GF_recep_IV; Growth factor receptor domain IV
  28. NM_001382805.1NP_001369734.1  receptor tyrosine-protein kinase erbB-2 isoform aa precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:746875
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712736
    PKc_like; Protein Kinases, catalytic domain
  29. NM_001382806.1NP_001369735.1  receptor tyrosine-protein kinase erbB-2 isoform bb precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (4) summary
    COG3170
    Location:717846
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    cl21453
    Location:406644
    PKc_like; Protein Kinases, catalytic domain
  30. NM_004448.4NP_004439.2  receptor tyrosine-protein kinase erbB-2 isoform a precursor

    See identical proteins and their annotated locations for NP_004439.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC079199, AC087491, BC167147
    Consensus CDS
    CCDS32642.1
    UniProtKB/Swiss-Prot
    P04626
    UniProtKB/TrEMBL
    X5DNK3
    Related
    ENSP00000269571.4, ENST00000269571.10
    Conserved Domains (8) summary
    cd12094
    Location:641684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:557603
    FU; Furin-like repeats
    cd00064
    Location:235280
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:712990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:720976
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:511643
    GF_recep_IV; Growth factor receptor domain IV

RNA

  1. NR_110535.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Related
    ENST00000578373.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    39688094..39728660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450643.1XP_024306411.1  receptor tyrosine-protein kinase erbB-2 isoform X3

    Conserved Domains (5) summary
    cd12094
    Location:657700
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:7281006
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159354
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:527659
    GF_recep_IV; Growth factor receptor domain IV
  2. XM_024450642.1XP_024306410.1  receptor tyrosine-protein kinase erbB-2 isoform X2

    Conserved Domains (5) summary
    cd12094
    Location:672715
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:7431021
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:174369
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:37158
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:542674
    GF_recep_IV; Growth factor receptor domain IV
  3. XM_024450641.1XP_024306409.1  receptor tyrosine-protein kinase erbB-2 isoform X1

    Conserved Domains (5) summary
    cd12094
    Location:687730
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:7581036
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189384
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:557689
    GF_recep_IV; Growth factor receptor domain IV
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