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Psmb5 proteasome (prosome, macropain) subunit, beta type 5 [ Mus musculus (house mouse) ]

Gene ID: 19173, updated on 6-Jun-2021

Summary

Official Symbol
Psmb5provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 5provided by MGI
Primary source
MGI:MGI:1194513
See related
Ensembl:ENSMUSG00000022193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in adrenal adult (RPKM 108.4), ovary adult (RPKM 85.6) and 28 other tissues See more
Orthologs
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Genomic context

See Psmb5 in Genome Data Viewer
Location:
14 C2; 14 27.86 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54851577..54855452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54614120..54617995, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (55232957..55236832, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931414P19 gene Neighboring gene U6 small nuclear RNA, pseudogene 1 Neighboring gene microRNA 686 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 11 Neighboring gene cadherin-like 24

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118075

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-5
Names
macropain epsilon chain
multicatalytic endopeptidase complex epsilon chain
proteasome beta type subunit 5
proteasome chain 6
proteasome epsilon chain
proteasome subunit X
NP_035316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011186.1NP_035316.1  proteasome subunit beta type-5

    See identical proteins and their annotated locations for NP_035316.1

    Status: VALIDATED

    Source sequence(s)
    AF060091
    Consensus CDS
    CCDS27095.1
    UniProtKB/Swiss-Prot
    O55234
    Related
    ENSMUSP00000022803.5, ENSMUST00000022803.6
    Conserved Domains (1) summary
    cd03761
    Location:60247
    proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54851577..54855452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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