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Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) [ Mus musculus (house mouse) ]

Gene ID: 17319, updated on 8-Oct-2019

Summary

Official Symbol
Mifprovided by MGI
Official Full Name
macrophage migration inhibitory factor (glycosylation-inhibiting factor)provided by MGI
Primary source
MGI:MGI:96982
See related
Ensembl:ENSMUSG00000033307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIF; DER6; Glif
Expression
Ubiquitous expression in ovary adult (RPKM 1212.9), kidney adult (RPKM 1020.4) and 28 other tissues See more
Orthologs

Genomic context

See Mif in Genome Data Viewer
Location:
10 38.59 cM; 10 C1
Exon count:
3
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75859353..75860277, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75322098..75322995, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 4 Neighboring gene glutathione S-transferase, theta 2 Neighboring gene predicted gene, 40697 Neighboring gene Der1-like domain family, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107654

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
cytokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
dopachrome isomerase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
phenylpyruvate tautomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phenylpyruvate tautomerase activity ISO
Inferred from Sequence Orthology
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain renin-angiotensin system ISO
Inferred from Sequence Orthology
more info
 
carboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
drinking behavior ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell aging ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mature B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adaptive immune response NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myeloid leukocyte cytokine production involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of prostaglandin secretion involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
macrophage migration inhibitory factor
Names
L-dopachrome isomerase
L-dopachrome tautomerase
delayed early response protein 6
phenylpyruvate tautomerase
NP_034928.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010798.3NP_034928.1  macrophage migration inhibitory factor

    See identical proteins and their annotated locations for NP_034928.1

    Status: VALIDATED

    Source sequence(s)
    AC142499
    Consensus CDS
    CCDS23934.1
    UniProtKB/Swiss-Prot
    P34884
    UniProtKB/TrEMBL
    Q545F0
    Related
    ENSMUSP00000041149.6, ENSMUST00000038169.7
    Conserved Domains (1) summary
    pfam01187
    Location:2115
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    75859353..75860277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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