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Anapc1 anaphase promoting complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 17222, updated on 6-Jun-2021

Summary

Official Symbol
Anapc1provided by MGI
Official Full Name
anaphase promoting complex subunit 1provided by MGI
Primary source
MGI:MGI:103097
See related
Ensembl:ENSMUSG00000014355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ap; Mc; Apc1; Mcpr; tsg2; tsg24; AI047775; AI853536; AW547281; 2610021O03Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.6), limb E14.5 (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Anapc1 in Genome Data Viewer
Location:
2; 2 F1
Exon count:
50
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128452003..128529558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128610083..128687406, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (128435819..128513131, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family, member E4C Neighboring gene predicted gene, 39929 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
anaphase-promoting complex subunit 1
Names
cyclosome subunit 1
meiotic check point regulator
mitotic checkpoint regulator
testis-specific gene 24 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008569.2NP_032595.2  anaphase-promoting complex subunit 1

    See identical proteins and their annotated locations for NP_032595.2

    Status: VALIDATED

    Source sequence(s)
    AK034858, AK077847, BB676785, BC139002, BE987509
    Consensus CDS
    CCDS16715.1
    UniProtKB/Swiss-Prot
    P53995
    Related
    ENSMUSP00000014499.4, ENSMUST00000014499.10
    Conserved Domains (2) summary
    pfam01851
    Location:14671501
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150218
    ANAPC1; Anaphase-promoting complex subunit 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    128452003..128529558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248086.2XP_030103946.1  anaphase-promoting complex subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam01851
    Location:13491383
    PC_rep; Proteasome/cyclosome repeat
    pfam18122
    Location:16181777
    APC1_C; Anaphase-promoting complex sub unit 1 C-terminal domain
  2. XM_011239332.4XP_011237634.1  anaphase-promoting complex subunit 1 isoform X2

    Related
    ENSMUSP00000105962.2, ENSMUST00000110333.2
    Conserved Domains (1) summary
    pfam12859
    Location:150218
    ANAPC1; Anaphase-promoting complex subunit 1

RNA

  1. XR_004938638.1 RNA Sequence

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