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Hoxa10 homeobox A10 [ Mus musculus (house mouse) ]

Gene ID: 15395, updated on 23-Jun-2021

Summary

Official Symbol
Hoxa10provided by MGI
Official Full Name
homeobox A10provided by MGI
Primary source
MGI:MGI:96171
See related
Ensembl:ENSMUSG00000000938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hoxa-; Hox-1.; Hox-1.8; Hoxa-10
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in limb E14.5 (RPKM 27.5), subcutaneous fat pad adult (RPKM 20.5) and 6 other tissues See more
Orthologs
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Genomic context

See Hoxa10 in Genome Data Viewer
Location:
6 B3; 6 25.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52208177..52217834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52231197..52240854, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (52181196..52190853, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene homeobox A9 Neighboring gene predicted gene, 52902 Neighboring gene microRNA 196b Neighboring gene homeobox A11 Neighboring gene homeobox A11, opposite strand Neighboring gene homeobox A13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-A10
Names
homeo box A10
homeobox protein Hox-1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122950.2NP_001116422.1  homeobox protein Hox-A10 isoform b

    See identical proteins and their annotated locations for NP_001116422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC015583, BC050839
    Consensus CDS
    CCDS51775.1
    UniProtKB/Swiss-Prot
    P31310
    Related
    ENSMUSP00000112872.2, ENSMUST00000121043.2
    Conserved Domains (1) summary
    pfam00046
    Location:2377
    Homeobox; Homeobox domain
  2. NM_008263.3NP_032289.2  homeobox protein Hox-A10 isoform a

    See identical proteins and their annotated locations for NP_032289.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AC015583, BC050839
    Consensus CDS
    CCDS20147.2
    UniProtKB/Swiss-Prot
    P31310
    Related
    ENSMUSP00000120276.2, ENSMUST00000125581.2
    Conserved Domains (1) summary
    pfam00046
    Location:345398
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    52208177..52217834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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