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Csnk2a1 casein kinase 2, alpha 1 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 12995, updated on 6-Sep-2021

Summary

Official Symbol
Csnk2a1provided by MGI
Official Full Name
casein kinase 2, alpha 1 polypeptideprovided by MGI
Primary source
MGI:MGI:88543
See related
Ensembl:ENSMUSG00000074698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK2; Csnk2a; Csnk2a1-rs4
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.4), whole brain E14.5 (RPKM 26.5) and 28 other tissues See more
Orthologs
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Genomic context

See Csnk2a1 in Genome Data Viewer
Location:
2; 2 G3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152067851..152123772)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152226535..152281856)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152052576..152107588)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcription factor 15 Neighboring gene ribosomal protein S15A, pseudogene 7 Neighboring gene TBC1 domain family, member 20 Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein kinase CK2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase CK2 complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
casein kinase II subunit alpha
Names
CK II alpha
casein kinase II, alpha 1 polypeptide
casein kinase II, alpha 1 related sequence 4
NP_031814.2
XP_006498720.1
XP_011237574.1
XP_030102934.1
XP_030102935.1
XP_030102936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007788.3NP_031814.2  casein kinase II subunit alpha

    See identical proteins and their annotated locations for NP_031814.2

    Status: VALIDATED

    Source sequence(s)
    AK042898, AK146032, BF018216, BY015187, CA322616
    Consensus CDS
    CCDS16879.1
    UniProtKB/Swiss-Prot
    Q60737
    Related
    ENSMUSP00000096829.4, ENSMUST00000099224.10
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152067851..152123772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247076.2XP_030102936.1  casein kinase II subunit alpha isoform X1

    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  2. XM_006498657.5XP_006498720.1  casein kinase II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006498720.1

    UniProtKB/Swiss-Prot
    Q60737
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  3. XM_030247075.2XP_030102935.1  casein kinase II subunit alpha isoform X1

    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  4. XM_030247074.2XP_030102934.1  casein kinase II subunit alpha isoform X1

    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  5. XM_011239272.4XP_011237574.1  casein kinase II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011237574.1

    UniProtKB/Swiss-Prot
    Q60737
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
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