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Atg5 autophagy related 5 [ Mus musculus (house mouse) ]

Gene ID: 11793, updated on 25-May-2021

Summary

Official Symbol
Atg5provided by MGI
Official Full Name
autophagy related 5provided by MGI
Primary source
MGI:MGI:1277186
See related
Ensembl:ENSMUSG00000038160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ap; Pad; Apg5l; Atg5l; Paddy; C88337; AW319544; 2010107M05Rik; 3110067M24Rik
Summary
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 9.7), bladder adult (RPKM 9.2) and 28 other tissues See more
Orthologs
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Genomic context

See Atg5 in Genome Data Viewer
Location:
10 B2; 10 23.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (44144325..44240295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (44268322..44364299)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (43988164..44084097)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated glutamate (E)-rich protein 5, pseudogene 1 Neighboring gene coiled-coil domain containing 137 pseudogene Neighboring gene predicted gene, 40637 Neighboring gene predicted gene, 19229 Neighboring gene microRNA 1929 Neighboring gene predicted gene, 35028 Neighboring gene PR domain containing 1, with ZNF domain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in C-terminal protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aggrephagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aggrephagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within antigen processing and presentation of endogenous antigen IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of endogenous antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy of nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nitrosative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of histone H4-K16 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative stranded viral RNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative thymic T cell selection IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within otolith development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation by symbiont of host autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-translational protein modification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein lipidation involved in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cytokine production involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Atg12-Atg5-Atg16 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondria-associated endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314013.1NP_001300942.1  autophagy protein 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC155642, AK028315, BY126779, CD776008, CX223012
    UniProtKB/Swiss-Prot
    Q99J83
    Conserved Domains (1) summary
    pfam04106
    Location:2166
    APG5; Autophagy protein Apg5
  2. NM_001358596.1NP_001345525.1  autophagy protein 5 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC155642, AK028315, BY126779, CD776008
    Conserved Domains (1) summary
    pfam04106
    Location:79160
    APG5; Autophagy protein Apg5
  3. NM_053069.6NP_444299.1  autophagy protein 5 isoform 1

    See identical proteins and their annotated locations for NP_444299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC155642, AK028315, BY126779, CD776008
    Consensus CDS
    CCDS23824.1
    UniProtKB/Swiss-Prot
    Q99J83
    Related
    ENSMUSP00000044769.5, ENSMUST00000039286.5
    Conserved Domains (1) summary
    pfam04106
    Location:79270
    APG5; Autophagy protein Apg5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    44144325..44240295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313783.3XP_017169272.1  autophagy protein 5 isoform X2

    Conserved Domains (1) summary
    pfam04106
    Location:79189
    APG5; Autophagy protein Apg5
  2. XM_011243108.4XP_011241410.1  autophagy protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011241410.1

    UniProtKB/Swiss-Prot
    Q99J83
    Conserved Domains (1) summary
    pfam04106
    Location:79270
    APG5; Autophagy protein Apg5
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