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Elp3 elongator acetyltransferase complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362548, updated on 30-Sep-2021

Summary

Official Symbol
Elp3provided by RGD
Official Full Name
elongator acetyltransferase complex subunit 3provided by RGD
Primary source
RGD:2324506
See related
EnsemblRapid:ENSRNOG00000014291
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Brain (RPKM 278.7), Heart (RPKM 241.4) and 9 other tissues See more
Orthologs
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Genomic context

See Elp3 in Genome Data Viewer
Location:
15p11
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39754635..39816482, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48942866..49005074, complement)

Chromosome 15 - NC_051350.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 395 Neighboring gene prepronociceptin Neighboring gene annexin 2, pseudogene1 Neighboring gene ribosomal protein S17-like Neighboring gene nuclear GTPase, germinal center associated

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Elp3 gene: The Elp3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 412 organisms have orthologs with human gene Elp3
  • Orthologs

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphorylase kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA uridine(34) acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA wobble uridine modification ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
elongator complex protein 3
Names
elongation protein 3 homolog
rCG52086-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051350.1 Reference mRatBN7.2 Primary Assembly

    Range
    39754635..39816482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002728290.6XP_002728336.1  elongator complex protein 3 isoform X2

    See identical proteins and their annotated locations for XP_002728336.1

    UniProtKB/TrEMBL
    D4ACM1
    Related
    ENSRNOP00000085019.1, ENSRNOT00000104506.1
    Conserved Domains (1) summary
    TIGR01211
    Location:37546
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
  2. XM_003751505.5XP_003751553.1  elongator complex protein 3 isoform X1

    See identical proteins and their annotated locations for XP_003751553.1

    Related
    ENSRNOP00000019262.7, ENSRNOT00000019262.8
    Conserved Domains (4) summary
    cd01335
    Location:115359
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR01211
    Location:56565
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    pfam00583
    Location:462555
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam16199
    Location:333411
    Radical_SAM_C; Radical_SAM C-terminal domain
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