Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 12794

1.

SNP genotyping of dogs Patagonian Sheepdogs

(Submitter supplied) Comparison of SNP profiles of the Patagonain Sheepdog with European breeds confirms Scottish origin and position basal to modern herding breeds.
Organism:
Canis lupus familiaris
Type:
SNP genotyping by SNP array; Genome variation profiling by SNP array
Platform:
GPL17481
146 Samples
Download data: IDAT, TXT
Series
Accession:
GSE193384
ID:
200193384
2.

Effects of ACTH-induced long-term hypercortisolemia on the transcriptome of canine visceral adipose tissue 

(Submitter supplied) Cushing’s syndrome is one of the most common endocrinopathies in adult dogs. It is a consequence of chronic hypercortisolemia (HC), that may present a pathological or iatrogenic origin. Among other alterations, Cushing’s syndrome involves the differential modulation of lipid metabolism, i.e., while enhanced lipolysis is observed in subcutaneous adipose tissue, an increased accumulation is observed in visceral adipose tissue (VAT). more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
10 Samples
Download data: TXT
Series
Accession:
GSE178108
ID:
200178108
3.

Transcriptomic profile of peripheral blood reveals potential genetic biomarkers for diagnosis of Osteoarthritis in German shepherd dogs

(Submitter supplied) Canine forms of osteoarthritis (OA) are very similar to those in humans and represent a welfare problem in the dog world population. In this study, we investigated the transcriptomic profile of peripheral blood in German Shepherd dogs with OA in order to identify diagnosis biomarkers. The bulk RNA-seq experiment was performed in a cohort of 12 adult dogs, 5 affected and 7 unaffected. Radiographs of the affected dogs revealed severe osteoarthritis in hip and elbow joints. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
12 Samples
Download data: CSV
Series
Accession:
GSE191273
ID:
200191273
4.

Canine DUXC isoforms and functional similarity to human DUX4

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Canis lupus familiaris
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL20988
17 Samples
Download data
Series
Accession:
GSE188928
ID:
200188928
5.

Canine DUXC isoforms and functional similarity to human DUX4 [RNA-seq]

(Submitter supplied) Human DUX4 and mouse Dux transcription factors are normally expressed in the germ line and early embryonic cells where they activate the cleavage stage genes. The misexpression of DUX4 in skeletal muscles causes Facioscapulohumeral dystrophy (FSHD). In primates and rodents, DUX4 and Dux arose from retrotransposition of the mRNA from the ancestral intron-containing DUXC, which is not found in these species, and whether it has similar roles in the cleavage stage and FSHD as DUX4 and Dux are unknown. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20988
12 Samples
Download data: RDA, XLSX
Series
Accession:
GSE188927
ID:
200188927
6.

Canine DUXC isoforms and functional similarity to human DUX4 [ChIP-seq]

(Submitter supplied) Human DUX4 and mouse Dux transcription factors are normally expressed in the germ line and early embryonic cells where they activate the cleavage stage genes. The misexpression of DUX4 in skeletal muscles causes Facioscapulohumeral dystrophy (FSHD). In primates and rodents, DUX4 and Dux arose from retrotransposition of the mRNA from the ancestral intron-containing DUXC, which is not found in these species, and whether it has similar roles in the cleavage stage and FSHD as DUX4 and Dux are unknown. more...
Organism:
Canis lupus familiaris
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20988
5 Samples
Download data: RDA, XLSX
Series
Accession:
GSE188926
ID:
200188926
7.

Gene expression analysis in canine pemphigus

(Submitter supplied) We performed a comparative immunology case study of client-owned dogs to determine if immune and skin gene expression profiles in spontaneous canine pemphigus mirror those observed in human pemphigus
Organism:
Canis lupus familiaris
Type:
Other
Platform:
GPL28844
9 Samples
Download data: RCC, TXT
Series
Accession:
GSE171079
ID:
200171079
8.

Transcriptional profiling of canine acanthomatous ameloblastoma

(Submitter supplied) Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA) have clinicopathologic and molecular features in common with human ameloblastomas (AM), spontaneous CAA can serve as a useful translational model of disease. However, the molecular basis of CAA and how it compares to AM are incompletely understood. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21400
25 Samples
Download data: DIFF, TXT
Series
Accession:
GSE175876
ID:
200175876
9.

Single cell atlas for mammals, reptiles and birds

(Submitter supplied) The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening on animal cells is a powerful tool to reveal the expression patterns of viral entry genes for different hosts. But such exploration for SARS-CoV-2 remained limited. Here, we presented the broadest pan-species single-nucleus RNA sequencing study to date, covering 11 representative species in pets (cat, dog, hamster, lizard), livestock (goat, rabbit), poultry (duck, pigeon) and wildlife (pangolin, tiger, deer), from which we investigated the co-expression of ACE2 and TMPRSS2. more...
Organism:
Capra aegagrus; Manis javanica; Cervus nippon taiouanus; Anas platyrhynchos; Canis lupus familiaris; Anolis carolinensis; Panthera tigris altaica; Oryctolagus cuniculus; Mesocricetus auratus; Columba livia; Felis catus
Type:
Expression profiling by high throughput sequencing
11 related Platforms
29 Samples
Download data: TXT
Series
Accession:
GSE183300
ID:
200183300
10.

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL20988
28 Samples
Download data
Series
Accession:
GSE183191
ID:
200183191
11.

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning [canine data]

(Submitter supplied) We developed a method using canine osteosarcoma in mouse xenografts to distinguish tumor-derived from host-response exosomal mRNAs. The model allows for the identification of canine osteosarcoma-specific gene signatures by RNA sequencing and a species-differentiating bioinformatics pipeline. An osteosarcoma-associated signature consisting of five gene transcripts was validated in dogs with osteosarcoma. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20988
20 Samples
Download data: TXT
Series
Accession:
GSE183189
ID:
200183189
12.

Paired-end RNA Sequencing on Madin-Darby Canine Kidney (G-MDCK) epithelial cells infected or not with Listeria monocytogenes and residing on varying stiffness substrates.

(Submitter supplied) Purpose: When we infect MDCK epithelial cells we low dosage of Listeria monocytogenes, we observe that at late times (24 h) post-infection the infected cells pertaining in infection foci get collectively extruded out of the epithelial monolayer forming a 3D mound. The formation of the infection mound results from the competition between two populations: the uninfected cells ("surrounders") that eventually squeeze and extrude the infected cells ("mounders") in the infected wells. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
24 Samples
Download data: XLSX
Series
Accession:
GSE175784
ID:
200175784
13.

Experimental Babesia rossi infection induces hemolytic, metabolic, and viral response pathways in the canine host

(Submitter supplied) Babesia rossi is a leading cause of morbidity and mortality among the canine population of sub-Saharan Africa, but pathogenesis remains poorly understood. Previous studies of B. rossi infection were derived from clinical cases, in which neither the onset of infection nor the infectious inoculum were known. Here, we performed controlled B. rossi inoculations in canines and evaluated disease progression through clinical tests and whole blood transcriptomic profiling. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
28 Samples
Download data: TXT
Series
Accession:
GSE167201
ID:
200167201
14.

Time-course study of microarray transcriptome analysis in influenza virus-infected MDCK and TR7 cells.

(Submitter supplied) Comparative transcriptome analysis indicated that expression of apoptosis-related MX1 and MMP9 was suppressed in TR7 cells both before and during viral infection. Meanwhile, CDKN2A was upregulated in TR7 cells, and CCND3 and CASP7 were upregulated in MDCK cells, which supported that cell cycle arrest in TR7cells benefited influenza virus production.
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL11351
14 Samples
Download data: TXT
Series
Accession:
GSE181825
ID:
200181825
15.

Canine pimary osteosarcoma tissues vs. matched lung metastases

(Submitter supplied) Osteosarcomas (OS) have highly chaotic genomes, yet their cancer drivers are poorly defined. Given that cancer genes are conserved among mammals, cross-species genomics of naturally arising cancers opens a powerful approach to identifying oncogenic drivers to broaden the therapeutic opportunities for aggressive cancers. Here, we utilized a dog-to-human cross-species genomics combined with gain- and loss-of-function analysis to uncover novel OS driver genes.
Organism:
Canis lupus familiaris
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10156
16 Samples
Download data: TXT
Series
Accession:
GSE118130
ID:
200118130
16.

Predictive Models of Drug Response in Canine Osteosarcoma: A Prospective Clinical Trial Testing the COXEN Approach

(Submitter supplied) This was a prospective clinical trial testing the ability of gene expression models of drug sensitivity that were developed in human and canine cell lines and applied to outcomes in dogs treated with adjuvant carboplatin and/or doxorubicin. Tumor samples were collected prospectively, and gene expression analysis was conducted using Affymetrix Canine Genome 2.0 Arrays.
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL3738
109 Samples
Download data: CEL
Series
Accession:
GSE180303
ID:
200180303
17.

Longitudinal Study of Transcriptomic Changes Occurring Over the Course of CHOP Treatment in Canine Lymphoma

(Submitter supplied) The standard treatment for canine lymphoma (cL) is the CHOP chemotherapy protocol. Most cL patients treated with CHOP initially achieve remission but the duration varies and the majority of dogs eventually relapse with a multidrug resistant phenotype. This study assesses changes in gene expression occurring in cL tumor cell populations over the course of CHOP treatment. We measured gene expression using RNA-Seq on 15 cL patient samples taken prior to treatment and again 6 weeks into treatment.
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22370
30 Samples
Download data: TSV
Series
Accession:
GSE179920
ID:
200179920
18.

LncRNA-42060 Regulates Tamoxifen Sensitivity and Tumor Development via Regulating the miR-204-5p/SOX4 Axis in Canine Mammary Gland Tumor Cells

(Submitter supplied) Tamoxifen is the drug of choice for endocrine therapy of breast cancer. Its clinical use is limited by the development of drug resistance. There is increasing evidence that long non-coding RNAs (lncRNAs) are associated with tumor drug resistance. Therefore, we established two TAM-resistant cell lines, CHMpTAM and CHMmTAM. The different expression levels of lncRNA and miRNA in CHMmTAM and CHMm were screened by RNA sequencing, and the lncRNA-miRNA interactions were analyzed. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL27147
12 Samples
Download data: TXT
Series
Accession:
GSE164721
ID:
200164721
19.

A Pig BodyMap Transcriptome Reveals Diverse Tissue Physiologies and Evolutionary Dynamics of Transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Gallus gallus; Macaca mulatta; Homo sapiens; Felis catus; Ovis aries; Oryctolagus cuniculus; Rattus norvegicus; Canis lupus familiaris; Cavia porcellus; Sus scrofa; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
19 related Platforms
553 Samples
Download data: HIC, TXT
Series
Accession:
GSE162148
ID:
200162148
20.

A Pig BodyMap Transcriptome Reveals Diverse Tissue Physiologies and Evolutionary Dynamics of Transcription [RNA-Seq across species]

(Submitter supplied) Comprehensive transcriptomic survey of the pig (Sus scrofa) may lead to a better understanding of mechanisms of tissue specialization that underlie economic traits of this species and accelerate its use as a biomedical model. Here, we characterized four distinct transcript types (lncRNAs, TUCPs, miRNAs and circRNAs) in 31 adult pig tissues and two cell lines, together with protein-coding genes. We dissected their distinct structural and transcriptional features and uncovered transcriptome variability as related to tissue physiology. more...
Organism:
Mus musculus; Rattus norvegicus; Canis lupus familiaris; Cavia porcellus; Gallus gallus; Ovis aries; Oryctolagus cuniculus; Macaca mulatta; Felis catus
Type:
Expression profiling by high throughput sequencing
9 related Platforms
142 Samples
Download data: TXT
Series
Accession:
GSE162142
ID:
200162142
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid9615[Organism]|query=1|qty=130|blobid=MCID_61e79473fa520c664860ea44|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center