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Items: 1 to 20 of 106550

1.

SUMOylation of Jra regulates the immune response in the gut of Drosophila

(Submitter supplied) Purpose: To understand how SUMOylation of Jra regulates the gut immune response in Drosophila in a Pseudomonas infection model. To answer this, we performed 2 RNA-seq experiments one with knockdown of Jra in the gut and the other with a SUMO-conjugation resistant mutant (SCR) line generated by CRISPR/Cas9 technology. Methods: 50-60 midguts from adult female flies were dissected and total RNA was extracted in trizol. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17275
42 Samples
Download data: CSV
Series
Accession:
GSE194168
ID:
200194168
2.

The Transcriptional Response to Oxidative Stress is Independent of Stress-Granule Formation

(Submitter supplied) We characterized oxidative-stress-induced transcriptional changes in Drosophila S2 cells and assessed how these were altered under conditions that disrupted stress granule (SG) assembly. Sodium-arsenite stress for 3 hours resulted predominantly in the induction or upregulation of stress-responsive mRNAs whose levels peaked during cell recovery after stress cessation. RNAi-mediated knock down of the conserved G3BP1/ Rasputin protein inhibited stress-granule assembly. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17275
36 Samples
Download data: TXT
Series
Accession:
GSE178464
ID:
200178464
3.

Evolutionary and phenotypically plastic response of adult gene expression to larval undernutrition in Drosophila melanogaster

(Submitter supplied) This RNAseq study has been performed in the framework of a project using experimental evolution to understand the consequences of genetically-based adaptation to juvenile undernutrition for adult gene metabolism. Six "Selected" populations of Drosophila melanogaster had been maintained on a very poor larval diet (3.2 g yeast / liter w/v) for 14 years (about 250 generations). Six "Control" populations of the same origin had been maintained in parallel on the standard diet (12.5 g yeast/liter). more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21306
24 Samples
Download data: TSV, TXT
Series
Accession:
GSE193105
ID:
200193105
4.

Natural variation in the transcriptional response of Drosophila melanogaster to oxidative stress

(Submitter supplied) Broadly distributed species must cope with diverse and changing environmental conditions, including various forms of stress. Cosmopolitan populations of Drosophila melanogaster are more tolerant to oxidative stress than those from the species’ ancestral range in sub-Saharan Africa, and the degree of tolerance is associated with an insertion/deletion polymorphism in the 3’ untranslated region of the Metallothionein A (MtnA) gene that varies clinally in frequency. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
48 Samples
Download data: CSV
Series
Accession:
GSE174813
ID:
200174813
5.

The transcriptomic signature of physiological trade-offs caused by larval overcrowding in Drosophila melanogaster

(Submitter supplied) This study examined the transcriptomic response of Drosophila melanogaster larvae to crowding conditions. The phenotypic and transcriptomic changes from low larval density (5 eggs/ml) to medium density (60 eggs/ml) were minor, yielding somewhat reduced adult fitness and only 24 differentially expressed genes (DEGs). In contrast, high density (300 eggs/ml) caused extensive detrimental effects on adult fitness and yielded 2107 DEGs. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13304
9 Samples
Download data: TXT
Series
Accession:
GSE193120
ID:
200193120
6.

ICP22 of Herpes Simplex Virus 1 decreases RNA Polymerase Processivity

(Submitter supplied) These data files consist of Illumina next seq 500 sequencing data from precision nuclear run-on and global nuclear run-on experiments conducted with human epithelial Hep2 cells that have been infected with human herpes simplex virus-1 (F) strain mutants. The results of these studies suggest that ICP22 is necessary for reducing Pol II processivity on the viral genome which results in its maintenance on the viral genome over the course of infection. more...
Organism:
Human alphaherpesvirus 1; Drosophila melanogaster; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29914
32 Samples
Download data: BW
Series
Accession:
GSE169574
ID:
200169574
7.

The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains prooncogenic properties of the Ski/Sno family

(Submitter supplied) To detect dysregulated genes upon overexpression of the functional smad suppressing element (fuss) in Drosophila melanogaster, we overexpressed fuss with the GMR-Gal4 line in developing eye discs and with the nub-Gal4 driverline in developing wing discs. The offspring of crossings of the driver lines GMR-Gal4 or nub-Gal4 with w1118 were used as controls. Libraries were generated from total RNA and sequenced on a Illumina HiSeq 1000. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15334
12 Samples
Download data: XLSX
Series
Accession:
GSE165738
ID:
200165738
8.

Recent Cis-Trans Coevolution Driven by the Emergence of A Novel Gene in Drosophila

(Submitter supplied) Young, or newly evolved, genes arise ubiquitously across the tree of life, and can rapidly acquire novel functions that influence a diverse array of biological processes (Chen et al. 2013)1. Previous work identified a young regulatory gene in Drosophila, Zeus, which diverged rapidly from its parent Caf40 and took on roles in the male reproductive system. This neofunctionalization was accompanied by differential binding of the Zeus protein to loci throughout the Drosophila melanogaster genome Chen et al. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17275
13 Samples
Download data: BED
Series
Accession:
GSE192880
ID:
200192880
9.

To perform a standard RNAseq experiment to evaluate the impact of the knockout of Zeus gene(CG9573) in D. melanogaster

(Submitter supplied) This experiment was designed to study the transcriptional alternations using RNA-seq technique. RNA materials were collected and sequenced with multiple experimental groups in tri-plicates as follows: control-knockout-replicate 1~3 (KO-Ctrl__1~3), Zeus-knockout-replicate 1~3 (KO-Zeus__1~3), for RNA-sequencing. In total, 6 sequencing files were downloaded from the genomic core facility, University of Chicago. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21306
6 Samples
Download data: TXT
Series
Accession:
GSE192879
ID:
200192879
10.

Intergenerational metabolic priming by sperm piRNAs

(Submitter supplied) Preconception parental environment can reproducibly program offspring phenotype without altering the DNA sequence, yet the mechanisms underpinning this ‘epigenetic inheritance’ remains elusive. Here, we demonstrate the existence of an intact piRNA-pathway in mature Drosophila sperm and show that pathway modulation alters offspring gene transcription in a sequence-specific manner. We map a dynamic small RNA content in developing sperm and find that the mature sperm carry a highly distinct small RNA cargo. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL19132
34 Samples
Download data: TSV
Series
Accession:
GSE172107
ID:
200172107
11.

A comprehensive series of temporal transcription factors in the fly visual system

(Submitter supplied) The brain consists of hundreds or thousands of different neuronal types that are generated through multiple divisions of neuronal stem cells. These stem cells have the capacity to generate different neuronal types at different stages of their development. In Drosophila, this temporal patterning is driven by the successive expression of temporal transcription factors (tTFs). While a number of tTFs are known in different animals and across various parts of the nervous system, these have been mostly identified by informed guesses and antibody availability. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
10 Samples
Download data: RDS
Series
Accession:
GSE167266
ID:
200167266
12.

Temporal transcriptome changes in Drosophila eye development

(Submitter supplied) we have performed mRNA-Seq studies of the larval eye and antennal primordial at multiple timepoints within the third larval instar and white prepupal stages
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9061
12 Samples
Download data: XLSX
Series
Accession:
GSE164079
ID:
200164079
13.

Identification of gene expression changes in sleep mutants associated with reduced longevity in Drosophila

(Submitter supplied) Sleep deprivation has become a common problem in modern society, yet the physiological consequences of sleep deprivation remain poorly understood. By analyzing the sleep and longevity profiles from a panel of Drosophila sleep mutants, we discovered a positive correlation between sleep duration and lifespan. To identify the genetic connection between sleep and longevity, we profiled the transcriptomes of wild type flies, old wild type flies, and two sleep mutants insomniac1 and wide awakeD2 at timepoints around the clock. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
46 Samples
Download data: TXT
Series
Accession:
GSE148136
ID:
200148136
14.

Caliban regulates mitochondrial morphology and redox state in enterocytes to maintain intestinal homeostasis in Drosophila

(Submitter supplied) Precise regulation of stem cell activity is crucial for tissue homeostasis. In Drosophila, intestinal stem cells (ISCs) maintain the midgut epithelium and respond to oxidative challenges by increasing proliferation rates. However, the connection between intestinal homeostasis and redox signaling remains obscure. Here we identify Caliban (Clbn) as a novel mitochondrial protein involved in regulating the cellular redox state in enterocytes (ECs) and the proliferative activity of ISCs. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Platform:
GPL1322
6 Samples
Download data: CEL
Series
Accession:
GSE125032
ID:
200125032
15.

Drosophila photoreceptor transcriptome landscape upon disruption of Clock activity [Rh1-ClkDN_RNA]

(Submitter supplied) We report the transcriptome landscape of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion upon expression of a Clock dominant negative mutant
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17275
12 Samples
Download data: TXT
Series
Accession:
GSE184121
ID:
200184121
16.

Drosophila photoreceptor nuclear RNA-seq timecourse [AgingATACseq]

(Submitter supplied) We report the chromatin accessibility landscape of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17275
15 Samples
Download data: BW
Series
Accession:
GSE184069
ID:
200184069
17.

Drosophila photoreceptor chromatin accessibility landscape upon disruption of Clock activity [ClkATACseq]

(Submitter supplied) We report the chromatin accessibility landscape of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion upon expression of a Clock dominant negative mutant
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17275
12 Samples
Download data: BW
Series
Accession:
GSE183746
ID:
200183746
18.

Wnt signaling modulates amyloid beta induced stem cell loss

(Submitter supplied) Wnt signaling has well established roles in development and cancer progression. Its roles during normal adult homeostasis are less well studied, but Wnt is a major stem cell regulating factor in adult tissues. Here we use an optogenetic model of amyloid beta aggregation to examine the effect of Wnt signaling on protein aggregation. We observe that Wnt activation rescues the detrimental effects of Amyloid. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21306
11 Samples
Download data: RESULTS
Series
Accession:
GSE181844
ID:
200181844
19.

Drosophila photoreceptor nuclear RNA-seq timecourse

(Submitter supplied) We report the nuclear transcriptome of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17275
19 Samples
Download data: TXT
Series
Accession:
GSE174515
ID:
200174515
20.

Nuclear RNA-seq of Drosophila Top3beta-deficient photoreceptor neurons

(Submitter supplied) We report the nuclear transcriptome of Drosophila Top3beta-deficient photoreceptor neurons obtained using a tissue-specific approach to purify nuclei and express an siRNA against Top3beta or mCherry for negative control
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17275
4 Samples
Download data: TXT
Series
Accession:
GSE174491
ID:
200174491
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