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Items: 1 to 20 of 4348

1.
Full record GDS6063

Influenza A effect on plasmacytoid dendritic cells

Analysis of primary plasmacytoid dendritic cells (pDC) exposed to influenza A for 8 hours ex vivo. pDCs are vital to antiviral defense, directing immune responses via secretion of interferon-alpha. Results provide insight into the regulation of the response of pDC to viral pathogens.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 individual, 2 infection sets
Platform:
GPL10558
Series:
GSE68849
10 Samples
Download data
2.
Full record GDS6010

Influenza virus H5N1 infection of U251 astrocyte cell line: time course

Analysis of U251 astrocyte cells infected with the influenza H5N1 virus for up to 24 hours. Results provide insight into the immune response of astrocytes to H5N1 infection.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 infection, 3 time sets
Platform:
GPL6480
Series:
GSE66597
18 Samples
Download data: TXT
3.
Full record GDS5879

Pulmonary CDC11c+ cells from young and middle-age animals

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL6885
Series:
GSE71868
8 Samples
Download data
4.
Full record GDS5826

Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib

Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 cell line, 2 cell type sets
Platform:
GPL570
Series:
GSE69078
12 Samples
Download data: CEL
5.
Full record GDS5825

Interleukin-1α deficiency effect on injured spinal cord

Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE70302
12 Samples
Download data: CEL
6.
Full record GDS5881

Nebulin deficiency effect on the soleus

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
7.
Full record GDS5880

Nebulin deficiency effect on the quadriceps

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
8.
Full record GDS5913

SRPIN803 small molecule inhibitor of SRPK1 effect on retinal pigment epithelial cell line

Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL570
Series:
GSE62947
6 Samples
Download data: CEL
DataSet
Accession:
GDS5913
ID:
5913
9.
Full record GDS5665

Pathogen-associated molecular-pattern curdlan effect on interleukin-2 deficient GM-CSF myeloid dendritic cells

Analysis of GM-CSF myeloid dendritic cells (GM-DCs) isolated from interleukin-2 (IL-2) knockouts and activated with curdlan, a pathogen-associated molecular pattern (PAMP). GM-DCs secrete cytokines such as IL-2, upon PAMP activation. Results provide insight into role of IL-2 signaling in DCs.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE58120
12 Samples
Download data: CEL
DataSet
Accession:
GDS5665
ID:
5665
10.
Full record GDS5662

Histone demethylase KDM3A-deficiency effect on estrogen-stimulated breast cancer cells in vitro

Analysis of estrogen receptor (ER)-positive breast cancer cell line MCF-7 depleted for KDM3A (histone lysine demethylase 3A) then treated with estrogen. Histone lysine methylation is an important regulator of transcription. Results provide insight into role of KDM3A in ER signaling in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL10558
Series:
GSE68918
11 Samples
Download data
11.
Full record GDS5948

Zipper-interacting protein kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of zipper-interacting protein kinase (ZIPK). ZIPK is phosphorylated and activated by Rho-associated kinase 1 (ROCK1). These results, together with those from GDS5659, provide further insight into ROCK1 and ZIPK functions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE56819
6 Samples
Download data: CEL
12.
Full record GDS5659

Rho-associated kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of Rho-associated kinase 1 (ROCK1). ROCK1 phosphorylates and activates zipper-interacting protein kinase (ZIPK). These results, together with those from GDSxxxx, provide further insight into ROCK1 and ZIPK functions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE56819
6 Samples
Download data: CEL
13.
Full record GDS5658

Retinoid X receptor activation effect on stimulated RAW264.7 cells

Analysis of RAW 264.7 macrophages pre-treated with vitamin A derivative 9cis-retinoic acid (9cRA), then stimulated with bacterial LPS or viral mimetic polyI:C. 9cRA is a high affinity ligand for retinoid X receptor (RXR). Results provide insight into the role of RXR in host antiviral response.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol, 3 stress sets
Platform:
GPL1261
Series:
GSE62107
6 Samples
Download data: CEL, CHP
14.
Full record GDS5661

Interleukin 7 and FLT-3 ligand effect on EML1 HSPC line expressing acute lymphoblastic leukemia TEL-AML1 fusion protein: time course

Analysis of TEL-AML1 oncogene-expressing hematopoietic stem/progenitor cell line EML1 treated with interleukin 7 (IL7) and FLT3 ligand (FLT3L) for up to 7 days. IL7 and FLT3L treatment induces B-cell differentiation. Results provide insight into the role of TEL-AML1 in early B-cell differentiation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 protocol, 3 time sets
Platform:
GPL11533
Series:
GSE64919
12 Samples
Download data: CEL
DataSet
Accession:
GDS5661
ID:
5661
15.
Full record GDS5657

Transcription factor Cabut deficiency and overexpression effects on heads: time course

Analysis of heads from strains overexpressing Cabut (cbtOE) or depleted for Cabut (cbtRNAi) at two time points during the day-night cycle (i.e., 3 hr after light-on or light-off). Krüppel‐like factors Klf10 and Klf11 are close mammalian homologs of cbt. Results provide insight into role of CBT.
Organism:
Drosophila melanogaster
Type:
Expression profiling by array, transformed count, 3 genotype/variation, 2 time sets
Platform:
GPL1322
Series:
GSE67865
6 Samples
Download data: CEL
16.
Full record GDS5655

Lymphotoxin-β receptor agonist antibody effect on lipopolysaccharide-stimulated embryonic fibroblasts

Analysis of MEFs treated for 24hrs with ligands lipopolysaccharide (LPS), lymphotoxin-β receptor agonist antibody (LTβR), and LPS+ LTβR. Results provide insight into molecular mechanisms underlying a potentially synergistic effect of LTβR signaling on LPS-TLR4 signaling.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL6885
Series:
GSE62301
4 Samples
Download data
17.
Full record GDS5656

Forkhead box O 1,3,4 muscle-specific knockout effect on fasted gastrocnemius muscle

Analysis of gastrocnemius muscle from starved males with muscle-specific deletion of Forkhead Box O transcription factors 1, 3 and 4 (FoxO1,3,4-/-). Results provide insight into the collective roles of FoxOs during muscle atrophy.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 stress sets
Platform:
GPL1261
Series:
GSE52667
4 Samples
Download data: CEL
18.
Full record GDS6100

MicroRNA-135b overexpression effect on prostate cancer cell line: time course

Analysis of LNCaP prostate cancer (PCa) cells overexpressing miRNA-135b for up to 36 hours. LNCaP cells express the androgen receptor (AR). MiRNA-135b overexpression in AR+ PCa cells results in slower growth compared to AR knockdown. Results provide insight into the basis of this slower growth.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE57820
12 Samples
Download data
19.
Full record GDS5660

Early postnatal skeletal muscle stem cells: time course

Analysis of myogenic stem cells called satellite cells (mSCs) FACS-sorted from the trunk of Pax3GFP/+ mice at postnatal days 1, 12, and 28, a period when most mSCs are in proliferation and quiescence states. Results provide insight into molecular basis of early postnatal skeletal muscle development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 age, 2 tissue sets
Platform:
GPL1261
Series:
GSE65927
11 Samples
Download data: CEL
DataSet
Accession:
GDS5660
ID:
5660
20.
Full record GDS5624

Epigenetic modifying reagents effect on a progressive hearing loss model: whole cochlea

Analysis of cochlea from 4 wk old DBA/2J males (a model of progressive hearing loss) injected for 8 wks with a combination of epigenetic modifiers l-methionine and valproic acid. Results provide insight into the effect of epigenetic modifications on the molecular mechanisms underlying hearing loss.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 3 protocol sets
Platform:
GPL1261
Series:
GSE62173
16 Samples
Download data: CEL
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