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Items: 1 to 20 of 891842

1.

A novel whole blood gene expression signature for asthma, dermatitis and rhinitis multimorbidity in BAMSE and INMA cohort

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
457 Samples
Download data: CEL
Series
Accession:
GSE141661
ID:
200141661
2.

A novel whole blood gene expression signature for asthma, dermatitis and rhinitis multimorbidity in INMA cohort

(Submitter supplied) Allergic diseases correspond to a broad range of hypersensitivity reactions, often occurring as co-morbidities. Investigation of the molecular basis of allergy is a challenge because of its highly heterogeneous nature. We combined large-scale and high-throughput gene expression technology and systems biology approaches to retrieve relevant biomarkers and signalling pathways.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
201 Samples
Download data: CEL
Series
Accession:
GSE141631
ID:
200141631
3.

A novel whole blood gene expression signature for asthma, dermatitis and rhinitis multimorbidity in BAMSE cohort

(Submitter supplied) Allergic diseases correspond to a broad range of hypersensitivity reactions, often occurring as co-morbidities. Investigation of the molecular basis of allergy is a challenge because of its highly heterogeneous nature. We combined large-scale and high-throughput gene expression technology and systems biology approaches to retrieve relevant biomarkers and signalling pathways.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
256 Samples
Download data: CEL
Series
Accession:
GSE141623
ID:
200141623
4.

The proteasome inhibitor MG132 adjusts the transcriptome in Brassica napus roots

(Submitter supplied) The goal of this study was to determine how proteasome inhibition alters the transcriptome in Brassica napus roots. Specifically, we wished to see if proteasome inhibition resulted in transcriptome signatures of oxidative stress, protein catabolism, or nitrogen assimilation
Organism:
Brassica rapa; Brassica napus
Type:
Expression profiling by array
Platform:
GPL10733
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE127923
ID:
200127923
5.

Expression data from prostate tissues from mouse models of prostate cancer fed a high-fat diet or a control diet.

(Submitter supplied) To examine the effects of high-fat diet on gene expression in the prostate of a mouse model of prostate cancer, we extracted RNA from the prostates, and evaluated their gene expressions using microarrays.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
10 Samples
Download data: CEL
Series
Accession:
GSE184381
ID:
200184381
6.

Transcriptional data from overexpression of OsBIERF3 rice

(Submitter supplied) We used microarrays to understand the downstream target genes regulated by OsBIERF3 transcription factor.
Organism:
Oryza sativa
Type:
Expression profiling by array
Platform:
GPL2025
4 Samples
Download data: CEL
Series
Accession:
GSE189749
ID:
200189749
7.

Comparison between HPV+ / p16+ versus the HPV-/p16- from HNSCC patients

(Submitter supplied) Head and neck squamous cell carcinomas are heterogeneous neoplasms that show clinical and biological differences in association with the human papillomavirus (HPV). To provide adequate therapeutic strategies, biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Reports on HNSCC are scarce in Mexico, thus in the present study, we analyze 414 cases of HNSCC, including those of the oropharynx (OPSCC), larynx (LASCC), and oral cavity (OCSCC). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
25 Samples
Download data: CEL
Series
Accession:
GSE181805
ID:
200181805
8.

Insights into ROS-dependent signalling underlying transcriptomic plant responses to the herbicide 2,4-D

(Submitter supplied) The synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D) functions as an agronomic weed control herbicide. High concentrations of 2,4-D induce plant growth defects, particularly leaf epinasty and stem curvature. Although the 2,4-D phenotype is associated with ROS production, little is known about ROS-dependent signalling. In this study, by using T-DNA Arabidopsis mutants to silence peroxisomal acyl CoA oxidase 1 (acx1-2), we identified ACX1 as one of the main sources of ROS production and as partly the cause of the epinasty phenotype following the application of 2,4-D. more...
Organism:
Arabidopsis thaliana
Type:
Expression profiling by array
Platform:
GPL198
24 Samples
Download data: CEL
Series
Accession:
GSE179303
ID:
200179303
9.

Type I interferon pathways in SARS-CoV-2-infected individuals from Pakistan

(Submitter supplied) Blood transcriptomes were determined in COVID-19 cases and healthy controls using the Clariom S RNA microarray, Affymetrix assay.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
47 Samples
Download data: CEL, CHP
Series
Accession:
GSE177477
ID:
200177477
10.

MicroRNA array expression during normal urinary bladder wound healing

(Submitter supplied) Urinary bladder wound healing is today pooorly chracterized. MicroRNAs are small non-coding RNA molecules with regulatory functions. In this study we aimed at identifying microRNAs expressed during bladder wound healing. We performed Affymetrix microRNA profiling of the rodent urinary bladder during healing of a surgically created wound.
Organism:
synthetic construct; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL21572
16 Samples
Download data: CEL
Series
Accession:
GSE176515
ID:
200176515
11.

Expression data from SW620/sh control and SW620/shMACC1

(Submitter supplied) MACC1 is a decisive driver of metastasis. In this data set the expression changes of shRNA mediated knock down is analyzed. We used microarrays to detail the global programme of gene expression changing upon MACC1 knock down.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE175995
ID:
200175995
12.

Intratumor genomic heterogeneity in stage II colon cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; Other
Platforms:
GPL21558 GPL15520
128 Samples
Download data: CEL, OSCHP, VCF
Series
Accession:
GSE172191
ID:
200172191
13.

Affymetrix OncoScan SNP arrays for profiling copy-number alterations (CNAs) and loss-of-heterozygosity (LOH) in colon cancer

(Submitter supplied) Intratumor heterogeneity fosters the evolution of the genome leading to metastatic progress and therapy resistance . Here, we investigate the relative contribution of tumor aneuploidy and genomic heterogeneity involving CNAs and mutational events as prognostic and predictive determinants for disease recurrence in early-stage colon cancer patients. We combined SNP arrays, targeted next-generation sequencing, fluorescence in situ hybridization and inmunohistochemistry on a retrospective cohort of 84 untreated stage II colon cancer patients. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL21558
84 Samples
Download data: CEL, OSCHP
Series
Accession:
GSE171777
ID:
200171777
14.

Comparative profiling of hippocampal gene expression in AppNL-G-F knock-in mouse model of Alzheimer's disease.

(Submitter supplied) To identify molecular pathological alterations in Alzheimer’s disease (AD) brains, we had previously performed comparative gene expression profiling with human gene array using RNAs prepared from postmortem human brains donated for the Hisayama study. The hippocampi from AD brains showed the most significant alteration in gene expression profile (PMID: 23595620). In the present study, in order to obtain a comprehensive view of gene expression profiles in AD hippocampus, we applied human transcriptome array and deep RNA-sequencing to the same samples and reanalyzed the gene array data, and performed integrative analysis of all 3 methods. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE157161
ID:
200157161
15.

A viral receptor mediating erythroid differentiation and cell migration is downregulated in myelodysplastic syndromes

(Submitter supplied) The major Coxsackie-Adenovirus receptor, CAR, is specifically down-regulated in immature erythroid progenitor cells in patients with MDS CAR mediates erythroid maturation in progenitor cells and their migration which may explain the maturation defect and pathology in MDS
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
34 Samples
Download data: CEL, CHP
Series
Accession:
GSE147963
ID:
200147963
16.

miRNA expression data from neonatal and adult human livers

(Submitter supplied) The liver is a major site of drug metabolism and many of these hepatic enzymes are differentially expressed with age. Since many of these changes have unknown mechanisms, we wanted to idenfity miRNAs that may be controlling the expression of these proteins.
Organism:
synthetic construct; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL21572
20 Samples
Download data: CEL, CHP
Series
Accession:
GSE132763
ID:
200132763
17.

Gene repression by DNA methylation promotes axon regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; synthetic construct
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by array
Platforms:
GPL17021 GPL21572
17 Samples
Download data: CEL, TXT
Series
Accession:
GSE90477
ID:
200090477
18.

miRNA-9 regulates axon regeneration through the transcriptional regulator REST and the epigenetic factor UHRF1 [miRNA array]

(Submitter supplied) Injured sensory neurons successfully activate a pro-regenerative transcriptional program to enable axon regeneration and functional recovery, but the roles of genes that are inactivated after injury remain poorly understood. Analysis of the miRNA expression profile triggered by axon injury revealed down-regulation of the neural development associated miRNA, miR-9. A target of miR-9 is the critical epigenetic regulator involved in DNA methylation, ubiquitin-like containing PHD ring finger 1 (UHRF1), which increased after injury to promote axon regeneration. more...
Organism:
Mus musculus; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL21572
11 Samples
Download data: CEL, TXT
Series
Accession:
GSE90475
ID:
200090475
19.

Effects of Methylprednisolone (MP) to Spinal Cord Injury

(Submitter supplied) Spinal cord injury (SCI) causes serious and complex secondary injury mechanism that leads to function deficit in daily life. How to treat devastating SCI is a critical issue in clinical medicine. This study explores effect of Methylprednisolone (MP) in temporal change of gene expression to look for candidate genes that have potential to develop effective treatment.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
60 Samples
Download data: CEL
Series
Accession:
GSE15878
ID:
200015878
20.

Gene expression profile of azacitidine- and decitabine- resistant HTLV-1-infected cell lines

(Submitter supplied) We generated azacitidine (AZA)- and decitabine (DAC)-resistant (AZA-R and DAC-R, respectively) cells from drug-sensitive ATL cell lines TL-Om1 and MT-2 via long-term drug exposure. To identify molecular mechanisms responsible for acquired resistance, we performed transcriptome analysis using Clariom S microarray.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
6 Samples
Download data: CEL
Series
Accession:
GSE166980
ID:
200166980
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