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Items: 1 to 20 of 9079

1.

Ultradian Molecular Rhythms Emerge in the Absence of a Circadian Clock

(Submitter supplied) In the chronobiology field, a fundamental dichotomy exists to explain daily rhythmicity of biological processes: these can be elicited in response to cyclic extrinsic/environmental signals such as light, or driven endogenously by the circadian clock. In mammals, the circadian clock ticks in almost every cell of the body, and functions based on a network of transcription-translation feedback loops. The PI3K-AKT signaling pathway relays environmental information of nutritional/metabolic state to regulate cell size and proliferation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
140 Samples
Download data
Series
Accession:
GSE171975
ID:
200171975
2.

Minimal Genomic Instability and Increased Immune Activity Differentiate EBV-positive PTCL from ENKTL and PTCL NOS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Expression profiling by array
Platforms:
GPL18602 GPL21558 GPL23126
165 Samples
Download data: CEL
Series
Accession:
GSE160120
ID:
200160120
3.

Bromodomain protein 9 (BRD9) regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4

(Submitter supplied) Macrophages induce a number of inflammatory response genes in response to stimulation with microbial ligands. In response to endotoxin Lipid A, lineage-defining and stimulation-responsive transcription factors cooperate to induce a gene activation cascade of primary followed by secondary response genes. Epigenetic state is an important regulator of the kinetics, specificity, and mechanism of gene activation of these two classes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21103 GPL19057
104 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE176146
ID:
200176146
4.

Characterization of the IL23-IL17 immune axis in IBD patients

(Submitter supplied) The aim of this study is to investigate the molecular mechanisms of IL23-IL17 immune axis in IBD, with particular attention to its role in maintaining mucosal barrier integrity under both physiological and pathological conditions
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
170 Samples
Download data: TSV
Series
Accession:
GSE165512
ID:
200165512
5.

The conservation and divergence of epigenitic reprogramming during mammalian early development

(Submitter supplied) To explore how parental epigenetic information is transmitted to the next generation across mammals, we systematically investigated the epigenomes of oocytes and early embryos among human, bovine, porcine, rat, and mouse. This unprecedented dataset revealed strikingly diverse, species-specific innovation of epigenetic transition. In oocytes, DNA methylation is restricted to active gene bodies in rodents, allowing methylation of maternal imprints but not intergenic paternal imprints. more...
Organism:
Sus scrofa; Bos taurus; Mus musculus; Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
188 Samples
Download data: BW, TXT
Series
Accession:
GSE163620
ID:
200163620
6.

Single-cell RNA-sequencing reveals pervasive but highly cell type-specific genetic ancestry effects on the response to viral infection

(Submitter supplied) Humans show remarkable variation in susceptibility to infectious diseases as well as chronic inflammatory and autoimmune disorders. This heterogeneity arises partially from variation in the immune response, which is responsible for preventing and controlling infection. To better understand the major factors driving antiviral immune response differences, we used single-cell RNA-sequencing to measure the effects of genetic ancestry and cis-regulatory variation on the transcriptional response to influenza infection in various immune cell types in 90 European and African American individuals. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
292 Samples
Download data: MTX, TSV, TXT
Series
Accession:
GSE162632
ID:
200162632
7.

Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks [Amplicon III]

(Submitter supplied) Complex gene regulatory networks ensure that important genes are expressed at precise levels. When gene expression within these networks is sufficiently perturbed it can lead to disease. To understand how gene expression disruptions percolate through a network, we must first map the connections between regulatory genes and their downstream targets. However, it has been challenging to identify the upstream regulators for genes of interest. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL24676
108 Samples
Download data: TXT
Series
Accession:
GSE189523
ID:
200189523
8.

The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation

(Submitter supplied) Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA2-IIA efficiently hydrolyzes bacterial membranes. Here, we show that sPLA2-IIA impacts on the immune system by acting on the intestinal microbial flora. more...
Organism:
Mus musculus
Type:
Other
Platforms:
GPL17021 GPL16417
119 Samples
Download data: CSV, TXT
Series
Accession:
GSE189441
ID:
200189441
9.

Methylation studies in plains zebras

(Submitter supplied) An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from many tissues of plains zebras (Equus quagga). Both whole blood (96) and remote biopsy (24) samples were obtained from a captive population of zebras maintained in a semi-wild state. After eliminating samples with low confidence for individual identity and age, we retained 76 blood samples and 20 biopsy samples, totaling 96 zebra samples.
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus; Equus burchellii quagga
Type:
Methylation profiling by array
Platform:
GPL28271
118 Samples
Download data: CSV, DOCX, IDAT
Series
Accession:
GSE184223
ID:
200184223
10.

Methylation studies in horses

(Submitter supplied) An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from many tissues from horses We generated DNA methylation data from n=333 horse tissue samples representing tissues. Blood samples were collected via venipuncture into EDTA tubes from across 24 different horse breeds (buffy coat). The other tissues were collected at necropsy. The tissue atlas was generated from two Thoroughbred mares as part of the FAANG initiative 37, with the following tissues profiled: adipose (gluteal), adrenal cortex, blood (PBMCs; only n=1 mare), cartilage (only n=1 mare), cecum, cerebellum (2 samples each from lateral hemisphere and vermis), frontal cortex, duodenum, fibroblast, heart (2 samples each from the right atrium, left atrium, right ventricle, left ventricle), hypothalamus, ileum, jejunum, keratinocyte, kidney (kidney cortex and medulla), lamina, larynx (i.e. more...
Organism:
Mus musculus; Homo sapiens; Equus caballus; Rattus norvegicus
Type:
Methylation profiling by array
Platform:
GPL28271
333 Samples
Download data: IDAT, TXT
Series
Accession:
GSE174767
ID:
200174767
11.

Methylation profiling reveals novel molecular classes of rhabdomyosarcoma

(Submitter supplied) Rhabdomyosarcomas (RMS) represent a family of aggressive soft tissue sarcomas that present in both the pediatric and adult setting. Pathologic risk stratification for RMS has been based on histologic subtype, with poor outcomes observed in alveolar rhabdomyosarcoma (ARMS) and adult-type pleomorphic rhabdomyosarcoma (PRMS) compared to embryonal rhabdomyosarcoma (ERMS). Recent genomic sequencing studies have expanded the spectrum of RMS, with several new molecularly defined entities, including fusion-driven spindle cell/sclerosing rhabdomyosarcoma (SC/SRMS) and MYOD1-mutant SC/SRMS. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL23976
158 Samples
Download data: IDAT
Series
Accession:
GSE167059
ID:
200167059
12.

Novel biomarkers for a personalized managemnet of Type II Diabetes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
296 Samples
Download data
Series
Accession:
GSE164673
ID:
200164673
13.

Novel biomarkers for a personalized managemnet of Type II Diabetes [adipose, liver, muscle]

(Submitter supplied) Quantitative measurement of circulating metabolites may help to identify tissue specific metabolic pathways that are modulated by or causal for a disease condition. The aim of the study was to explore associations between plasma lipid concentrations and gene expression in pancreatic β-cells and insulin target tissues in a mouse model of pre-diabetes to uncover molecular mechanisms and biomarkers of diabetes susceptibility.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
224 Samples
Download data: TXT
Series
Accession:
GSE164672
ID:
200164672
14.

Early-life nasopharyngeal gene expression profiles in the context of the local microbiota and viral infection.

(Submitter supplied) We studied nasopharyngeal gene expression profiles in infants from just after birth until 1 year of age. We used microarrays to detail the gene expression profiles over time. These gene expression maturation profiles were related to previously generated microbiota data, viral detection data and host and environmental factors (Bosch et al. AJRCCM 2017; SRP093519).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
286 Samples
Download data: CEL
Series
Accession:
GSE152951
ID:
200152951
15.

Clinical and biological relevance of the transcriptomic-based prostate cancer metastasis subtypes MetA-C

(Submitter supplied) Transcriptomic profiling of metastasis tissue samples obtained from prostate cancer patients was performed using Clariom D human arrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23126
103 Samples
Download data: CEL
Series
Accession:
GSE189343
ID:
200189343
16.

Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies unique proteotypes associated with patient outcomes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL10558 GPL14951
110 Samples
Download data
Series
Accession:
GSE166999
ID:
200166999
17.

Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies unique proteotypes associated with patient outcomes [WG-DASL]

(Submitter supplied) Non-small cell lung cancer (NSCLC) death rates exceed the next 3 prevalent cancers combined; however, most NSCLC tumors lack actionable mutations. Recent studies of NSCLC and other cancers revealed profound proteome remodelling with prognostic impact that is not fully predicted by DNA or RNA analyses. These revelations portend proteome-based cancer classification and treatment. This will require model systems that recapitulate tumor proteomes and phenotypes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14951
100 Samples
Download data: TXT
Series
Accession:
GSE166998
ID:
200166998
18.

The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis

(Submitter supplied) ARABIDOPSIS THRITHORAX-RELATED PROTEINS 5 (ATXR5) AND ATXR6 are required for the deposition of H3K27me1 and for maintaining genomic stability in Arabidopsis. Reduction of ATXR5/6 activity results in activation of DNA damage response genes, along with tissue-specific derepression of transposable elements, chromocenter decompaction, and genomic instability characterized by accumulation of excess DNA from heterochromatin. more...
Organism:
blank sample; Arabidopsis thaliana
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL21785 GPL26208 GPL29487
241 Samples
Download data: BW, FPKM_TRACKING, TXT, WIG
Series
Accession:
GSE166897
ID:
200166897
19.

Intermittent PI3Kα/β/δ Inhibitor Treatment Alleviates Immunosuppressive Environment in PTEN-null prostate Cancer and facilitate Anti-PD-1 Therapy

(Submitter supplied) Examination of gene expression level in tumor tissue or CD8T cell in vehicle, BAY1082439 (Single dose), BAY1082439 daily/intermittent treatment, BAY1082439 treatment release drug treatment group. Examination of gene expression level in CAP2 CAP8 PC3 and LNCaP cell line in vehicle or BAY1082439 treatment. Examination of gene expression level in spleen CD8T cell in vehicle or intermittent BAY1082439 treatment.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL20795 GPL21273
140 Samples
Download data: TXT
Series
Accession:
GSE159660
ID:
200159660
20.

A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL25864
204 Samples
Download data: TXT
Series
Accession:
GSE123088
ID:
200123088
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