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Items: 1 to 20 of 122666

1.

Transcriptomic profile of non-alcoholic fatty liver disease in rat induced by high-fat diet

(Submitter supplied) This study aimed to investigate the effect and underlying mechanism of Smilax china L.(SCL) on lipid metabolic disturbance in rats with non-alcoholic fatty liver disease (NAFLD). Rats were administrated with a high-fat diet (HFD) for 8 weeks to induce NAFLD, followed by SCL treatment for further 6 weeks.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
9 Samples
Download data: TXT
Series
Accession:
GSE189855
ID:
200189855
2.

Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression

(Submitter supplied) Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings, and include products such as flame retardants, artificial film-forming foams, cosmetics, non-stick cookware among others. Epidemiological studies suggest a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism through which PFAS impact cancer development is unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
23 Samples
Download data: CSV, TXT
Series
Accession:
GSE185183
ID:
200185183
3.

The effects of MuRF1 knockout, sex, and a high fat diet consumption on gastrocnemius muscle transcriptomics.

(Submitter supplied) MuRF1 is an E3 ubiquitin ligase known to play a role in skeletal muscle atrophy. Our objectives in this study were to gain further insight into the roles MuRF1 plays in skeletal muscle and to determine if this is influenced by sex and/or consumption of a high fat diet. To address these objectives we used RNA sequencing to analyze the transcriptome of gastrocnemius muscle from 30 week old, MuRF1 knockout (-/-) and wild type, male and female mice fed a chow or high fat diet (HFD).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
31 Samples
Download data: TXT
Series
Accession:
GSE179163
ID:
200179163
4.

SO018 visceral adipose tissue gene expression

(Submitter supplied) identification of the effect of transgenerationnal supplementation with omega 3 fatty acids on the resistance to a diet induced obesity challenge identification of the effect of transgenerationnal supplementation with omega 3 fatty acids on the resistance to a diet induced obesity challenge
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21163
20 Samples
Download data: TXT
Series
Accession:
GSE176356
ID:
200176356
5.

Desmosterol suppresses inflammasome activation and protects against atherosclerosis II

(Submitter supplied) Cholesterol biosynthetic intermediates such as lanosterol and desmosterol are emergent immune regulators of macrophages in response to inflammatory stimuli or lipid overloading, respectively. However, the participation of these sterols in regulating macrophage functions in the physiological context of atherosclerosis, an inflammatory disease driven by the accumulation of cholesterol-laden macrophages in the artery wall, has remained elusive. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
16 Samples
Download data: TXT
Series
Accession:
GSE175312
ID:
200175312
6.

Next Generation Sequencing Facilitates Quantitative Analysis of Brown Adipose Tissues from 3bKO and fl/fl Control Mice after 20-week High-Fat Diet Feeding

(Submitter supplied) A persistent influx of energy due to intake over expenditure leads to obesity. Increasing energy expenditure through activation of brown fat thermogenesis is a promising therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key player in regulating brown fat development and thermogenic program. Here we aimed to study the role of DNA methyltransferase 3b (Dnmt3b), a DNA methyltransferase involved in de novo DNA methylation, in the regulation of brown fat function and energy homeostasis during diet-induced obesity (DIO). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: XLSX
Series
Accession:
GSE173765
ID:
200173765
7.

Genome-wide liver transcriptomic profiles from chow-fed, high fat diet (HFD) fed, and HFD + AC261066 (Retinoic Acid Receptor Beta-2 Selective Agonist) fed mice

(Submitter supplied) Using a high fat diet (HFD) mouse model of nonalcoholic fatty liver disease (NAFLD) with 60% of the energy derived from fat, we determined the effects of AC261066, a RARbeta2 selective agonist, on the liver transcriptome. We analyzed disease signature pathways using our genome-wide RNA-seq data from AC260166 treated livers and show that AC261066 limits the mRNA increases of NAFLD driver genes PKLR, FASN, THRSP, and CHCHD6. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
18 Samples
Download data: XLSX
Series
Accession:
GSE165855
ID:
200165855
8.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

(Submitter supplied) Hexokinases (HK) catalyze the first step of glycolysis and thereby limit its pace. HK2 is highly expressed in the gut epithelium, plays a role in immune responses and is upregulated in inflammation and ulcerative colitis 1-3. Here, we examined the microbial regulation of HK2 and its impact on intestinal inflammation by generating mice lacking HK2 specifically in intestinal epithelial cells (Hk2∆IEC). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
38 Samples
Download data: TXT
Series
Accession:
GSE158026
ID:
200158026
9.

Dysregulation of miRNA regulatory networks by chronic ethanol consumption impairs liver regeneration

(Submitter supplied) In this study, we elucidated the role of miRNA dysregulation in liver regeneration after partial hepatectomy (PHx) in chronic ethanol-treated rats. Male Sprague-Dawley rats were fed a liquid diet containing 36% of total calories derived from ethanol for 5 weeks; corresponding pair-fed calorie-matched controls were fed diets in which ethanol calories were replaced by carbohydrate. After 5 weeks, locked nucleic acid (LNA)-modified oligo antisense to miR-21 (AM21, Exiqon) was used to inhibit miRNA in vivo, and rats were subjected to 70% PHx. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL15295
48 Samples
Download data: RCC
Series
Accession:
GSE171438
ID:
200171438
10.

Mouse kidney-specific genes

(Submitter supplied) Analysis of RNAs from multiple mouse tissues to find kidney-specific genes
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
19 Samples
Download data: XLSX
Series
Accession:
GSE189618
ID:
200189618
11.

RNA-next generation sequencing of intestine tissue from mice fed high fat diet or/and sugar drink

(Submitter supplied) Purpose: NGS was used to determine if a distinct transcriptomic profile is observed among the experimental mice fed four different dietary components. Methods: We carried out RNA-Seq analysis of ileum tissue from 6 weeks male mice ad libitum fed for 10 weeks a high liquid sugar (23% (w/v)) or/and high fat (60% Kcal from fat) diet. The combined effect of sugar drink and high fat diet (HF-Sugar) was compared with sugar drink only (NF-Sugar), or high fat diet only (HF), or control diet that was plain water and normal fat diet (NF). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18635
12 Samples
Download data: TXT
Series
Accession:
GSE140972
ID:
200140972
12.

Gene expression in rhesus monkey peripheral blood mononuclear cells (PBMCs) in response to long-term calorie restriction

(Submitter supplied) The effect of a long-term calorie restricted diet was evaluated in PBMCs of rhesus monkeys For biopsy collection, the animals were given buprenorphine (0.01-0.03 mg/kg, IM) in the morning immediately preceding all biopsies and again that afternoon
Organism:
Macaca mulatta
Type:
Expression profiling by array
Platform:
GPL3535
14 Samples
Download data: CEL, CHP
Series
Accession:
GSE64231
ID:
200064231
13.

Gene expression in gastrocnemius muscle in response to calorie restriction in wildtype and Sirt3 knockout mice

(Submitter supplied) The effect of calorie restriction from two to 12 months of age was evaluated in gastrocnemius muscle in both wildtype mice as well as Sirt3 knockout mice The dietary intervention was initiated at 2 months of age and continued until 12 months of age
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
15 Samples
Download data: CEL, CHP
Series
Accession:
GSE64229
ID:
200064229
14.

Gene expression in mouse hippocampus in response to long-term calorie restriction

(Submitter supplied) The effect of a long-term calorie restricted diet was evaluated in hippocampus of male mice The dietary intervention was initiated at 14 months of age and continued until 30 months of age
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE64226
ID:
200064226
15.

Gene expression in mouse kidney in response to long-term calorie restriction

(Submitter supplied) The effect of a long-term calorie restricted diet was evaluated in kidney of male mice The dietary intervention was initiated at 14 months of age and continued until 30 months of age
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE64151
ID:
200064151
16.

Gene expression in mouse liver in response to krill powder

(Submitter supplied) The effect of krill powder, a mixed source of protein and n-3 PUFAs from Antarctic Krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for three months. Gene expression profiling on liver samples revealed that the krill powder supplemented diet modulated a large number of pathways compared to the control diet, and we focused on the genes involved in metabolic processes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
14 Samples
Download data: CEL, CHP
Series
Accession:
GSE46049
ID:
200046049
17.

Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β-cell function [scATAC-seq]

(Submitter supplied) Circadian rhythm disruption (CD) is associated with dysregulation of glucose homeostasis and Type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates CD-induced metabolic dysfunction. Herein we utilized an approach encompassing analysis of behavioral, physiological, transcriptomic, and single-cell epigenomic effects of CD and consequences of restoration of fasting/feeding cycles through time-restricted feeding (tRF) in mice. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
6 Samples
Download data: H5, TSV
Series
Accession:
GSE182937
ID:
200182937
18.

Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β-cell function [ATACseq]

(Submitter supplied) Circadian rhythm disruption (CD) is associated with dysregulation of glucose homeostasis and Type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates CD-induced metabolic dysfunction. Herein we utilized an approach encompassing analysis of behavioral, physiological, transcriptomic, and single-cell epigenomic effects of CD and consequences of restoration of fasting/feeding cycles through time-restricted feeding (tRF) in mice. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: BW
Series
Accession:
GSE182936
ID:
200182936
19.

Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β-cell function [ChIPseq]

(Submitter supplied) Circadian rhythm disruption (CD) is associated with dysregulation of glucose homeostasis and Type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates CD-induced metabolic dysfunction. Herein we utilized an approach encompassing analysis of behavioral, physiological, transcriptomic, and single-cell epigenomic effects of CD and consequences of restoration of fasting/feeding cycles through time-restricted feeding (tRF) in mice. more...
Organism:
Rattus norvegicus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25029
2 Samples
Download data: BED, BW
Series
Accession:
GSE182933
ID:
200182933
20.

Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β-cell function [RNAseq]

(Submitter supplied) Circadian rhythm disruption (CD) is associated with dysregulation of glucose homeostasis and Type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates CD-induced metabolic dysfunction. Herein we utilized an approach encompassing analysis of behavioral, physiological, transcriptomic, and single-cell epigenomic effects of CD and consequences of restoration of fasting/feeding cycles through time-restricted feeding (tRF) in mice. more...
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL22396 GPL21103
42 Samples
Download data: XLSX
Series
Accession:
GSE182931
ID:
200182931
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db=gds|term=(smok*%20OR%20diet)%20AND%20(mammals[organism]%20NOT%20human[organism])|query=1|qty=65|blobid=MCID_61aa21f032fa8809a6437242|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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