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Items: 1 to 20 of 56701

1.

Modeling OTUD7A loss-of-function mutation in schizophrenia-associated 15q13.3 microdeletion in human neurons

(Submitter supplied) The edited lines introduced a premature termination at rs757148409/p.Arg89Ter. The mutant iNs showed a ~50% decrease in OTUD7A protein expression without undergoing nonsense-mediated mRNA decay. The mutant iNs also exhibited marked reduction of dendritic complexity, synaptic puncta density of AMPA receptor subunit GluA1 and postsynaptic scaffold PSD-95, as well as neural firing rate and network activity. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
10 Samples
Download data: TXT
Series
Accession:
GSE189614
ID:
200189614
2.

Differential interferon-α immune signatures prevent SARS-CoV-2 infection

(Submitter supplied) Type 1 interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control and immune-mediated pathology and have been successfully employed for the treatment of viral diseases. In humans, there are twelve IFN-alpha (α) subtypes, which activate downstream signalling cascades and result in a distinct pattern of immune responses and differential antiviral responses. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
60 Samples
Download data
Series
Accession:
GSE189613
ID:
200189613
3.

AMSC CD36+ subpopulations

(Submitter supplied) Adipose-derived MSCs (AMSC) are currently utilized in clinical trials for various diseases including osteoarthritis, amyotrophic lateral sclerosis, and multiple system atrophy. Whilst AMSCs may be defined by the surface expression of classical markers including CD44, CD90, CD105, and absence of CD45, these cells may exhbit donor-to-donor differences in differentiation potential. In this study we evaluated the expression of CD36 amongst AMSCs and utilized magnetic cell sorting to enrich for CD36+ cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data: TSV
Series
Accession:
GSE189525
ID:
200189525
4.

NGS Analysis of human mRNAs in mouse cells following a 12-hr 2D-coculture

(Submitter supplied) Background: We have previously known that mRNAs can transfer in mammalian cells via membrane nanotubes. However, genome-wide study of mRNA was lacking Objective: In this study, we wanted to characterize the range of human mRNAs that undergo transfer to neighbouring mouse cells when co-cultured together for 12 hours Results: We found that a large part of human mRNAs can traffic to adjoining mouse cells, the number of mRNAs transferred is dependent on gene expression. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL25526 GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE185002
ID:
200185002
5.

A spatio-temporally resolved single cell atlas of the Plasmodium liver stage

(Submitter supplied) To study the liver stage of the rodent malaria parasite Plasmodium berghei, we molecularly characterized thousands of infected and uninfected hepatocytes in different time points and inferred their spatial coordinates. Thus enabling us to characterize the host’s and parasite’s temporal expression programs in a zonally-controlled manner.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
62 Samples
Download data
Series
Accession:
GSE181725
ID:
200181725
6.

Comparative Transcriptome Analysis Reveals immunoregulation mechanism of lncRNA-mRNA in Large Yellow Croaker (Larimichthys crocea) in Response to Cryptocaryon irritans Infection

(Submitter supplied) Cryptocaryonosis caused by Cryptocaryon irritans is one of the major diseases of large yellow croaker (Larimichthys crocea), which lead to massive economic losses annually. The pathogenesis for cryptocaryonosis has been researched by a series of transcriptome studies under different infection conditions. However, little is known about the roles of tissue-specifically expressed genes during the infection of C. more...
Organism:
Larimichthys crocea
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30112
15 Samples
Download data
Series
Accession:
GSE174221
ID:
200174221
7.

Ultradian Molecular Rhythms Emerge in the Absence of a Circadian Clock

(Submitter supplied) In the chronobiology field, a fundamental dichotomy exists to explain daily rhythmicity of biological processes: these can be elicited in response to cyclic extrinsic/environmental signals such as light, or driven endogenously by the circadian clock. In mammals, the circadian clock ticks in almost every cell of the body, and functions based on a network of transcription-translation feedback loops. The PI3K-AKT signaling pathway relays environmental information of nutritional/metabolic state to regulate cell size and proliferation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
140 Samples
Download data
Series
Accession:
GSE171975
ID:
200171975
8.

Profiling and functional characterization of maternal mRNA translation in mouse maternal-to-zygotic transition

(Submitter supplied) Translational regulation plays an important role in gene expression and function. Although the transcriptional dynamics of mouse pre-implantation embryos has been well characterized, the global mRNA translation landscape and the master regulators of zygotic genome activation (ZGA) remain unknown. Here, by developing and applying a low-input ribosome profiling (LiRibo-seq) technique, we profiled the mRNA translation landscape in mouse pre-implantation embryos and revealed the translational dynamics during mouse pre-implantation development. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL19057 GPL13112
50 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE169632
ID:
200169632
9.

Polycomb repressive complex 1 (PRC1) role in lingual epithelium development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL21103
7 Samples
Download data: TDF, TSV, TXT
Series
Accession:
GSE123095
ID:
200123095
10.

Polycomb repressive complex 1 (PRC1) role in lingual epithelium development [RNA-seq]

(Submitter supplied) Polycomb repressive complexes (PRC) 1 is essential for the maintenance of lingual papillae pattern.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: TSV, TXT
Series
Accession:
GSE123094
ID:
200123094
11.

RNA-expression analysis on smooth muscle cells of diabetic donors after empagliflozin treatment

(Submitter supplied) Purpose: We report vascular effects of empagliflozin stimulation. Results: Gene set enrichment analysis of RNA-Seq showed negative regulation of vascular smooth muscle cell proliferation. Gene set overlapped by the vasoactive peptide apelin, being upregulated by empagliflozin treatment.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: TXT
Series
Accession:
GSE189538
ID:
200189538
12.

Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy

(Submitter supplied) Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic strategy in disease management. Here we define a molecular pathway through which recombinant interleukin-1 receptor antagonist (IL-1Ra, anakinra) affects cellular proteostasis independently from the IL-1 receptor (IL-1R1). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: XLS
Series
Accession:
GSE188809
ID:
200188809
13.

Transcriptomic profiling of MCF-7 breast cancer cells treated with G1, a G-protein coupled estrogen receptor (GPER1) agonist

(Submitter supplied) Application of next generation sequencing (NGS) technology to identify G1-modulated genes in MCF-7 breast cancer cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20795
9 Samples
Download data: XLSX
Series
Accession:
GSE188706
ID:
200188706
14.

Transcriptome-wide profile of 25-hydroxyvitamin D3 in primary immune cells from human peripheral blood

(Submitter supplied) In this study, we used PBMCs of five healthy individuals participating in the VitDHiD intervention trial (NCT03537027) and investigated in a transcriptome-wide approach the gene regulatory potential of 25(OH)D3 and D3 in reference to 1,25(OH)2D3 (GSE156124).
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
66 Samples
Download data: XLSX
Series
Accession:
GSE179225
ID:
200179225
15.

scRNAseq analysis of mouse WT and Fmr1KO dorsal root ganglions

(Submitter supplied) Sensory hypersensitivity and somatosensory deficits represent the core symptoms of Fragile X syndrome (FXS).These alterations are believed to arise from changes in cortical sensory processing, while potential deficits in the function of peripheral sensory neurons or surrounding satellite glial cells (SGCs) residing in dorsal root ganglia remain unexplored. We found that cultured peripheral sensory neurons exhibit pronounced hyperexcitability in Fmr1 KO mice evident in markedly increased firing rate and decreased spike threshold. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE176449
ID:
200176449
16.

INO80 complex promotes thermomorphogenesis by integrating H2A.Z eviction and active transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Arabidopsis thaliana
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL26208 GPL23157
32 Samples
Download data
Series
Accession:
GSE168120
ID:
200168120
17.

INO80 complex promotes thermomorphogenesis by integrating H2A.Z eviction and active transcription [RNA-seq]

(Submitter supplied) Global warming imposes a major threat to plant growth and crop production. In some plants including Arabidopsis thaliana, elevated temperatures induce a series of morphological and developmental adjustments, termed thermomorphogenesis to facilitate plant cooling under high-temperature conditions. Plant thermal response is suppressed by histone variant H2A.Z. At warm temperatures, H2A.Z is evicted from nucleosomes at thermo-responsive genes, resulting in their activation. more...
Organism:
Arabidopsis thaliana
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26208
24 Samples
Download data: TXT
Series
Accession:
GSE168118
ID:
200168118
18.

Differential gene expression analysis on cells expressing Wild type GFP-MAB21L1 and its mutant form GFP-Arg51Leu and GFP-Arg51Gln

(Submitter supplied) RNA Sequencing analysis was performed on RNA isolated from cells tagged with GFP-MAB21L1 and its mutant form GFP-Arg51Leu and GFP-Arg51Gln with and without treatment of tetracycline for 12 hrs. Transcript-level quantitation was performed using Salmon (v0.8.2) against the GRCh38 Ensembl reference transcriptome (release-89).Transcript-level counts were summarized to gene level using the bioconductor package tximport (v1.4.0). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
12 Samples
Download data: CSV
Series
Accession:
GSE166078
ID:
200166078
19.

Interleukin-22 (IL-22) regulates B3GNT7 expression to induce intestinal fucosylation of O-linked glycans

(Submitter supplied) Interleukin (IL) - 22 is a cytokine that plays a critical role in the maintenance of intestinal epithelial homeostasis. Its downstream functions are mediated through ligation of its heterodimeric receptor comprised of IL-22 receptor subunit alpha 1 (IL-22Ra1) and IL-10R2, and subsequent activation of signal transducer and activator of transcription 3 (STAT3). IL-22 signaling can induce genes necessary for intestinal epithelial cell proliferation, tissue regeneration, tight junction fortification, and production of antimicrobials. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
6 Samples
Download data: TXT
Series
Accession:
GSE154889
ID:
200154889
20.

Hyperbilirubinemia and phototherapy differentially alter hippocampal transcriptomic patterns in a Gunn rat model of neonatal hyperbilirubinemia.

(Submitter supplied) Neonatal hyperbilirubinemia (jaundice) is common in infants, with extremely preterm infants (EPT, <28 weeks gestational age) being at high risk for bilirubin-induced neurotoxicity, resulting in neurodevelopmental impairment. Hyperbilirubinemia is treated using phototherapy to lower unconjugated bilirubin levels. However, the benefits and risks of phototherapy in EPTs have not been well studied, and bilirubin at low levels may be protective as an antioxidant. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
20 Samples
Download data: TXT
Series
Accession:
GSE189509
ID:
200189509
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