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Items: 4

1.

rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin [Hi-C]

(Submitter supplied) Nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. Its role in regulating stem cell fate is unclear. Here, we present multiple lines of evidence that nucleolar stress induced by interfering rRNA biogenesis can drive two-cell stage embryo-like (2C-like) transcriptional program and induce an expanded 2C-like cell population in mouse embryonic stem (mES) cells. Mechanistically, the liquid-liquid phase separation (LLPS) mediated by rRNA and nucleolar proteins maintains the formation of peri-nucleolar heterochromatin (PNH). more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL17021
2 Samples
Download data: TXT
Series
Accession:
GSE166032
ID:
200166032
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

CX-5461 ES

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL17021
Series:
GSE166032 GSE166041
Download data: TXT
Sample
Accession:
GSM5060465
ID:
305060465
4.

Control ES

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL17021
Series:
GSE166032 GSE166041
Download data: TXT
Sample
Accession:
GSM5060464
ID:
305060464
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Supplemental Content

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