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Items: 1 to 20 of 63

1.

Optimized delivery of dual co-stimulation and anti-tumor activity using parallel chimeric antigen receptors (pCARs)

(Submitter supplied) Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory endodomain and elicit remarkable efficacy in hematological malignancies. Third generation (3G) CARs extend this linear blueprint by fusing both co-stimulatory units in series. However, clinical impact has been muted despite compelling evidence that co-signaling by CD28 and 41BB can powerfully amplify natural immune responses. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL29417
48 Samples
Download data: RCC
Series
Accession:
GSE186557
ID:
200186557
2.

Nanostring CAR T Characterization panel comparing expression in cord blood-derived transgenic T cells cultured with IL-2 or with IL-7 and IL-15, peripheral blood-derived transgenic T cells cultured with IL-2

(Submitter supplied) The purpose of the experiment was to transcriptionally characterize transgenic T cells derived from cord blood (CB) and cultured with IL-2 or IL-7 and IL-15, or from peripheral blood (PB) and cultured with IL-2. The sample replicates were generated using peripheral and cord blood mononuclear cells, obtained from healthy human donors and cord blood units that were not compliant with banking standards, respectively. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL29417
12 Samples
Download data: RCC
Series
Accession:
GSE161483
ID:
200161483
3.

NanoString nCounter CAR-T Characterization panel

(Submitter supplied) CodeSet Hybridization Setup MAN-10056 (https://www.nanostring.com/download_file/view/863/3778) + nCounter SPRINT® Profiler User Manual MAN-10017 (https://www.nanostring.com/download_file/view/254/3778)
Organism:
Homo sapiens
2 Series
60 Samples
Download data
Platform
Accession:
GPL29417
ID:
100029417
4.

Trunc CAR in pCAR_stimulated_replicate4

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655634
ID:
305655634
5.

Trunc CAR in pCAR_stimulated_replicate3

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655633
ID:
305655633
6.

Trunc CAR in pCAR_stimulated_replicate2

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655632
ID:
305655632
7.

Trunc CAR in pCAR_stimulated_replicate1

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655631
ID:
305655631
8.

Trunc CAR in pCAR_unstimulated_replicate4

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655630
ID:
305655630
9.

Trunc CAR in pCAR_unstimulated_replicate3

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655629
ID:
305655629
10.

Trunc CAR in pCAR_unstimulated_replicate2

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655628
ID:
305655628
11.

Trunc CAR in pCAR_unstimulated_replicate1

Organism:
Homo sapiens
Source name:
Human T-cells expressing 34BB/CTr CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655627
ID:
305655627
12.

1G CAR/ Dual CCR_stimulated_replicate4

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655626
ID:
305655626
13.

1G CAR/ Dual CCR_stimulated_replicate3

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655625
ID:
305655625
14.

1G CAR/ Dual CCR_stimulated_replicate2

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655624
ID:
305655624
15.

1G CAR/ Dual CCR_stimulated_replicate1

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655623
ID:
305655623
16.

1G CAR/ Dual CCR_unstimulated_replicate4

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655622
ID:
305655622
17.

1G CAR/ Dual CCR_unstimulated_replicate3

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655621
ID:
305655621
18.

1G CAR/ Dual CCR_unstimulated_replicate2

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655620
ID:
305655620
19.

1G CAR/ Dual CCR_unstimulated_replicate1

Organism:
Homo sapiens
Source name:
Human T-cells expressing 3428BB/CZ CAR, 24h stimulated on T47D cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655619
ID:
305655619
20.

pCAR-M/34_stimulated_replicate4

Organism:
Homo sapiens
Source name:
Human T-cells expressing p34BB/C CAR, 24h stimulated on T47D CSF1R cells
Platform:
GPL29417
Series:
GSE186557
Download data: RCC
Sample
Accession:
GSM5655618
ID:
305655618
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