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Items: 1 to 20 of 996036

1.

SFPQ-ABL1 and BCR-ABL1 utilise different signalling networks to drive B-cell acute lymphoblastic leukaemia

(Submitter supplied) Purpose: We identified a rare instance of the SFPQ-ABL1 in a child with Ph-like ALL. The overall purpose of this study was to compare the structure and function of the SFPQ-ABL1 fusion to the well characterised BCR-ABL1 fusion. We used phosphoproteomics, transcriptomics and functional assays to determine the transforming capacity, subcellular localisation, and signalling networks of these two fusions. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: TXT
Series
Accession:
GSE185860
ID:
200185860
2.

Chip-seq analyses of PPARγ bonded DNA fragments

(Submitter supplied) Chip-seq analyses of PPARγ bonded DNA fragments revealed that Arid5b, Rorb, Pank2 and Htr2c are the downstream target genes for PPARγ regulated adipogenesis in fetal preadipocyte.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: TXT
Series
Accession:
GSE185779
ID:
200185779
3.

Transcriptome-wide N6-methyladenine profiling in low input multiplex samples by a kit-free multi-barcode method

(Submitter supplied) N6-methyladnine, which is the most abundant post-transcriptional RNA modification in eukaryotic mRNA, has been proved to be essential in various biological processes and related to numerous diseases. Transcriptome-wide m6A profiling by next generation sequencing is widely used to explore the distributions as well as quantity of m6A modifications. As traditional m6A-seq demands large amount of starting RNA which limited its application to clinical samples, we present a strategy of low input multi-barcode m6A-seq (SLIM-m6A-seq) to realize simplified m6A profiling of mixed clinical samples. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL20795 GPL21273
10 Samples
Download data: CSV, XLSX
Series
Accession:
GSE185749
ID:
200185749
4.

IL-21-αHSA combined with TIGIT blockade induces an effective anti-tumor immune response

(Submitter supplied) IL-21-αHSA combined with TIGIT blockade induces an effective anti-tumor immune response, indicated by the significant enrichment of pathways associated with anti-tumor immune response, as well as significantly increased expression of key genes associated with CD8+ T and NK cell cytotoxicity To further understand the mechanisms by which IL-21-αHSA enhances the benefit of TIGIT blockade, we analyzed MC38 tumor tissues 20 days after five doses of both single agent and combination treatments by RNA sequencing (RNA-seq) of 28,758 genes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: TXT
Series
Accession:
GSE185727
ID:
200185727
5.

Single cell RNA sequencing analysis of the mouse colonic mesenchyme (Drop-seq)

(Submitter supplied) Single cell RNA sequencing of the mouse colonic mesenchyme. Mesenchymal/lamina propria cells were isolated from the middle and distal colon of wild type mice and were pooled. The vast majority of intestinal epithelial cells were depleted by Ethylenediaminetetraacetic acid (EDTA) treatment of the tissue samples and mesenchymal/lamina propria cells were isolated after enzymatic treatment with collagenase XI and dispase. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
1 Sample
Download data: TXT
Series
Accession:
GSE185638
ID:
200185638
6.

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells (RNA-Seq)

(Submitter supplied) Determine genome-wide open chromatin in P14 memory CD8 T cells 30 days after septic insult
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
11 Samples
Download data: XLSX
Series
Accession:
GSE174358
ID:
200174358
7.

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells (ATAC-Seq)

(Submitter supplied) Determine genome-wide open chromatin in P14 memory CD8 T cells 30 days after septic insult
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
5 Samples
Download data: XLS
Series
Accession:
GSE174357
ID:
200174357
8.

Global gene expression profile of anti-CD3/CD28 or PMA/ionomycin stimulated CD4+ T cell, wild type and Mapk1-KO CD4+ T cells, and empty vector and sh-Zfp831 infected CD4+ T cells

(Submitter supplied) Several factors promote Tfh cell differentiation. In order to understand how they promotes the expression of Tfh signature genes, we conducted transcriptional analysis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data: TXT
Series
Accession:
GSE163702
ID:
200163702
9.

Beta-catenin in cholangiocytes regulates immune environment and wound healing after hepatobiliary injury

(Submitter supplied) Identify differentially expressed genes in small mice cholangiocyte cell line (SMCC) when CTNNB1 is activated or silenced.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
12 Samples
Download data: CSV, WIG
Series
Accession:
GSE155981
ID:
200155981
10.

P16 positive microglia population identified in the aged mouse brain 

(Submitter supplied) Senescent cells are in a state of permanent cell cycle arrest, which is mediated by the Cyclin Dependent Kinase (CDK)4/6 inhibitor p16. During ageing, p16-expressing (P16pos) cells accumulate in tissues and promote multiple age-related pathologies, including neurodegenerative diseases. We evaluated the accumulation and the phenotype of senescent cells in the aged brain with a transgenic reporter mouse (p16-3MR), which allows for isolation of P16poscells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: CSV, TAR
Series
Accession:
GSE151459
ID:
200151459
11.

The histone lysine acetyltransferase HBO1 regulates hematopoietic stem cell quiescence and self-renewal

(Submitter supplied) KAT7 (HBO1) is a histone acetyltransferase required for histone H3 lysine 14 acetylation (H3K14ac) and normal levels of gene expression in hematopoietic stem and progenitor cells (HSPCs). The loss of H3K14ac was detected by western blot in whole bone marrow and by flow cytometry in specific HSPC populations. In order to determine the normal distribution of H3K14ac in the HSPC population a CUT&Tag experiment was performed using lineage negative, cKit positive Sca1 positive cells (LSK) and lineage negative, cKit positive Sca1 negative cells (progenitor cells). more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
5 Samples
Download data: TXT
Series
Accession:
GSE185820
ID:
200185820
12.

Endothelial UCP2 regulates the neurogenic-to-astrogenic fate switch during brain development

(Submitter supplied) Purpose: To gain futher insight into how endothelial UCP2 regulates the neurogenic-to-astrogenic fate switch ,RNA-seq was used to analyze the genome-wide changes resulting from isolated endothelial cells of E14.5 and E17.5 UCP2 endothelial conditional knock out mice and littermate wild-type. Methods: mRNA from E15 and E18 isolated endothelial cells of wild-type(WT) and UCP2f/f;Tie2-cre mice was extracted. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE185656
ID:
200185656
13.

Transcriptomic profies in control or NCOR1 deficient vascular smooth muscle cells

(Submitter supplied) NCOR1 is a trancriptional coregulator and has been demonstrated to modulate the acitivities of multiple transcription factors in many cell types. However, the function of NCOR1 in vascular smooth muscle cells (VSMCs) is unclear. We aimed to explore the effect of NCOR1 deficiency on gene expression in VSMCs and phenoypic modulation of VSMCs. Therefore, we constructed smooth-muscle specific NCOR1 knockout mice and isolated primary VSMCs for RNA-sequencing.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
6 Samples
Download data: XLS
Series
Accession:
GSE185635
ID:
200185635
14.

Phase Separation by the NUP98-HOXA9 Fusion Oncoprotein Drives an Oncogenic Phenotype in Hematopoietic Cells

(Submitter supplied) RNA-seq of mouse hematopoietic stem and progenitor cells expressing NUP98-HOXA9 (NHX9) show upregulation of HOX and other NUP98 fusion target genes, but expression changes are dampened or lost with the introduction of mutations in NUP98's FG repeats or HOXA9's DNA binding domain
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
35 Samples
Download data: TSV
Series
Accession:
GSE185621
ID:
200185621
15.

Tissue transcriptome atlas across DIO and lean mouse tissues

(Submitter supplied) RNA sequencing was performed on several tissues extracted from 5 lean and 5 diet-induced obese (DIO) mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
204 Samples
Download data: CSV
Series
Accession:
GSE185466
ID:
200185466
16.

Gene expression profiling in Nlrp3 deficient mice infected with Francisella tularensis

(Submitter supplied) This study investigated gene expression profile in wild type and nlrp3 deficient mice infected with F. tularensis LVS. RNA-sequencing was performed to determine the transcript levels of genes using total RNA extracted from lungs of wild type C57BL/6 and Nlrp3-/- mice infected with 1 × 104 CFU of F. tularensis LVS on days 3 and 7 post-infection.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
12 Samples
Download data: XLS
Series
Accession:
GSE183003
ID:
200183003
17.

Single cell RNA sequencing for normal and diseased mouse femoral artery

(Submitter supplied) Endothelial cells play a critical role in multiple cardiovascular diseases. CD34+ cells are believed to be endothelial progenitors that have been used to treat cardiovascular disease. However, the exact identity and the role of CD34+ cells in vascular regeneration remains unclear.Here we performed single cell RNA sequencing to identify heterogeneous CD34+ cells serve as a contributor to endothelial regeneration.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
5 Samples
Download data: TAR
Series
Accession:
GSE182232
ID:
200182232
18.

The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis

(Submitter supplied) The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis miR182 overexpression in primary cultured iWAT
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
6 Samples
Download data: TXT
Series
Accession:
GSE178952
ID:
200178952
19.

GFI1 tethers the nucleosome-remodeling and histone-deacetylase (NuRD) complex to open and transcriptionally active chromatin in myeloid progenitors

(Submitter supplied) Purpose: The goals of this study are to identify sites in genomic DNA that are occupied by GFI1 and the NurD complex, represented by its member the chromodomain helicase CHD4 or by a complex of GFI1 and CHD4 in myeloid precursors cells and to determined the effect on gene expression. Methods: Granulocytic-monocytic precursors (GMPs) as well as pre neutrophils and mature neutrophils were sorted by flow cytometry from murine bone marrow and sujected to RNA-seq and Chromatin-immuno-precipitation and sequencing (ChIP-Seq) and ATAC-seq procedures. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL13112
17 Samples
Download data: BROADPEAK, CSV, NARROWPEAK
Series
Accession:
GSE173533
ID:
200173533
20.

GRHL3 activates FSCN1 to relax cell adhesions between migrating keratinocytes in the wound front

(Submitter supplied) identify an underlying mechanism a new pathway where GRHL3 activates the Fscn1 gene to effect cell-cell loosening in the migrating wound front
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
11 Samples
Download data: BROADPEAK, TXT
Series
Accession:
GSE172161
ID:
200172161
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