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Items: 1 to 20 of 235

1.

positive regulation of telomeric DNA binding

Any process that activates or increases the frequency, rate or extent of telomeric DNA binding. Synonyms: activation of telomere binding; activation of telomeric DNA binding; activation of telomeric repeat binding; positive regulation of telomere binding; positive regulation of telomeric...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1311014
GO
: GO:1904744
2.

regulation of telomeric DNA binding

Any process that modulates the frequency, rate or extent of telomeric DNA binding. Synonyms: regulation of telomere binding; regulation of telomeric repeat binding;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1311012
GO
: GO:1904742
3.

positive regulation of telomere maintenance via telomere lengthening

Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. Synonyms: activation of telomere maintenance via telomere lengthening; up regulation of telomere maintenance via telomere lengthening; up-regulation of telomere...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1272284
GO
: GO:1904358
4.

negative regulation of telomere maintenance via telomere lengthening

Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. Synonyms: down regulation of telomere maintenance via telomere lengthening; down-regulation of telomere maintenance via telomere lengthening; downregulation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1272283
GO
: GO:1904357
5.

regulation of telomere maintenance via telomere lengthening

Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1272282
GO
: GO:1904356
6.

DNA Damage/Telomere Stress Induced Senescence

Reactive oxygen species (ROS), whose concentration increases in senescent cells due to oncogenic RAS-induced mitochondrial dysfunction (Moiseeva et al. 2009) or due to environmental stress, cause DNA damage in the form of double strand breaks (DSBs) (Yu and Anderson 1997). In addition,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Cellular Senescence

Cellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochromatic foci (SAHF), and changes in gene expression that result in secretion of a number...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Cellular responses to stress

Cells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissues to modulate molecular processes in response to such external stresses is essential...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

Meiotic synapsis

Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

Meiosis

During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

Packaging Of Telomere Ends

Multiple steps, including C-strand resection, telomerase-mediated elongation, and C-strand synthesis are involved in processing and maintaining the telomere. Though this module posits a linear transit for the steps, in humans it is not well understood how these steps are coordinated...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
12.

Telomere Maintenance

Telomeres are protein-DNA complexes at the ends of linear chromosomes that are important for genome stability. Telomeric DNA in humans, as in many eukaryotic organisms, consists of tandem repeats (Blackburn and Gall 1978; Moyzis et al. 1988; Meyne et al. 1989). The repeats at human...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
13.

Chromosome Maintenance

Chromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
14.

Cell Cycle

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
15.

macromolecular complex binding

Interacting selectively and non-covalently with any macromolecular complex.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
1129214
GO
: GO:0044877
16.

chromosomal region

Any subdivision of a chromosome along its length. Synonym: chromosome region;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
994751
GO
: GO:0098687
17.

single-organism organelle organization

An organelle organization which involves only one organism. Synonym: single organism organelle organization;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
925938
GO
: GO:1902589
18.

Shelterin complex

Structural complex; Genetic information processing; Replication system

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
890633
KEGG
: M00424
19.

positive regulation of chromosome organization

Any process that activates or increases the frequency, rate or extent of chromosome organization. Synonyms: positive regulation of chromosome organisation; positive regulation of chromosome organization and biogenesis; positive regulation of maintenance of genome integrity; positive...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
755358
GO
: GO:2001252
20.

negative regulation of chromosome organization

Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. Synonyms: negative regulation of chromosome organisation; negative regulation of chromosome organization and biogenesis; negative regulation of maintenance of genome integrity; negative...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
755357
GO
: GO:2001251

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