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Links from BioSystems

Items: 10

1.

PI3K-Akt signaling pathway

The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
2.

Adipocytokine signaling pathway

Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and metabolic rate primarily by acting at hypothalamic nuclei. Leptin exerts its anorectic...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
3.

Insulin signaling pathway

Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
4.

mTOR signaling pathway

The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
5.

Autophagy - animal

Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
6.

Cell cycle

Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
7.

Glycolysis / Gluconeogenesis

Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
8.

Biosynthesis of unsaturated fatty acids

Type
:
pathway
Taxonomic scope
:
conserved biosystem
9.

Fatty acid biosynthesis

Type
:
pathway
Taxonomic scope
:
conserved biosystem
10.

Starch and sucrose metabolism

Type
:
pathway
Taxonomic scope
:
conserved biosystem

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