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Conserved domains on  [gi|1443644224|ref|XP_025892383|]
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prokineticin receptor 2-like [Nothoprocta perdicaria]

Protein Classification

7tmA_prokineticin-R domain-containing protein (domain architecture ID 11606947)

7tmA_prokineticin-R domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-410 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


:

Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 526.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNY 199
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFivkKQEKIFCGQIWP 279
Cdd:cd15204    81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYG 359
Cdd:cd15204   158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1443644224 360 FTIVRDFFPTIFVKEKHYLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15204   238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
 
Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-410 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 526.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNY 199
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFivkKQEKIFCGQIWP 279
Cdd:cd15204    81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYG 359
Cdd:cd15204   158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1443644224 360 FTIVRDFFPTIFVKEKHYLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15204   238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
136-395 3.69e-52

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 333754 [Multi-domain]  Cd Length: 255  Bit Score: 175.96  E-value: 3.69e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 136 GNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 215
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFLLLTLPFWLVYYLHGT--WPFGSALCKLVTFLDVVNGYASILLLTAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 216 AVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATetvLFIVKKQEKIFCGQIWPVDQqmYYKSYFLFIFG 295
Cdd:pfam00001  79 SIDRYLAIVHPLRYRRIMRRAKAIILLIWVLALLLSLPPLLGWN---TLDIPSNGVTSCLITFPESL--WPVSYLLFSTV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 296 IEFVAPVITMTLCYARISRELWFKTVPGfqteqiRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRDFFPTIFVK-- 373
Cdd:pfam00001 154 LGFLLPLLVILVCYTRIIRTLRKQQSSS------IRSVRSERKALKTLLVVVVVFILCWLPYHILLLLDSLCDLGIIIsc 227
                         250       260
                  ....*....|....*....|....
gi 1443644224 374 --EKHYLTAFYIVECIAMSNSMIN 395
Cdd:pfam00001 228 evVTPPRTLLQLTVWLAYSNSCLN 251
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
82-421 3.62e-21

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 93.69  E-value: 3.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224  82 FTSFRNFTIPFNFNYSDYDLPLDNEDDVTKTRTFFAAKIVIGVALICIMLVCGIGNLIFIAALARYKkLRNLTNLLIANL 161
Cdd:PHA03087    3 YTLTINTTIENTTDYYYDTYYDEDYADCDLNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 162 AISDfIVAIVCCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVSTNALLAIAVDRYLAIVHPLK--PRMNYQTATFL 239
Cdd:PHA03087   82 AVSD-LLFVMTLPFQIYYYILFQWSF--GEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKsnKINTVKYGYIV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 240 IALVWTVSILVAIPSAYFATetvlfiVKKQEKIFCGQIWPVDQQMYYKSYFLF---IFGieFVAPVITMTLCYARISREL 316
Cdd:PHA03087  159 SLVIWIISIIETTPILFVYT------TKKDHETLICCMFYNNKTMNWKLFINFeinIIG--MLIPLTILLYCYSKILITL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 317 wfktvpgfQTEQIRKRlrcRRKTVMVLMCILIAYVLCWAPFYgftivrdffPTIFVKEKHYLT-------------AFYI 383
Cdd:PHA03087  231 --------KGINKSKK---NKKAIKLVLIIVILFVIFWLPFN---------VSVFVYSLHILHfksgckavkyiqyALHV 290
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1443644224 384 VECIAMSNSMINTMCFITVKNNTMKYFKKIMFLKWRST 421
Cdd:PHA03087  291 TEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTSS 328
 
Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-410 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 526.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNY 199
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFivkKQEKIFCGQIWP 279
Cdd:cd15204    81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYG 359
Cdd:cd15204   158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1443644224 360 FTIVRDFFPTIFVKEKHYLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15204   238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
120-410 7.61e-129

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 374.08  E-value: 7.61e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 199
Cdd:cd14992     1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSL--SWEYGHFLCKIVNY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPR--MNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQI 277
Cdd:cd14992    79 LRTVSVYASSLTLTAIAFDRYFAIIHPLKPRhrQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 278 WPVDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQ-TEQIRKRLRCRRKTVMVLMCILIAYVLCWAP 356
Cdd:cd14992   159 PPVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSiKEVERKRLKCKRRVIKMLVCVVVLFVICWLP 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1443644224 357 FYGFTIVRDFFPTiFVKEKHYLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd14992   239 FHLFFLLRDFFPL-IMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
128-395 1.25e-62

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 204.38  E-value: 1.25e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 128 CIMLVCGI-GNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLY 206
Cdd:cd15203     8 GLIIVLGVvGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKN--WPFGSILCKLVPSLQGVSIF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 207 VSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYF-ATETVLFIVKKQEKIFCGQIWPVDQqmY 285
Cdd:cd15203    86 VSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFqELSDVPIEILPYCGYFCTESWPSSS--S 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 286 YKSYFLFIFGIEFVAPVITMTLCYARISREL---WFK--TVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGF 360
Cdd:cd15203   164 RLIYTISVLVLQFVIPLLIISFCYFRISLKLrkrVKKkrGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNLF 243
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1443644224 361 TIVRDFFPTIFVKEKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd15203   244 NLLRDFEPLPQIDGRHFYLIFLICHLIAMSSACVN 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
120-410 7.72e-61

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 199.75  E-value: 7.72e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 199
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYR--PWVFGEVLCKAVPY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPR--MNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKK--QEKIFCG 275
Cdd:cd14993    79 LQGVSVSASVLTLVAISIDRYLAICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPgtITIYICT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 276 QIWPvdQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQT----EQIRKRLRCRRKTVMVLMCILIAYV 351
Cdd:cd14993   159 EDWP--SPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGsansTSSRRILRSKKKVARMLIVVVVLFA 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 352 LCWAPFYGFTIVRDFFPTIFVKEKH-YLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd14993   237 LSWLPYYVLSILLDFGPLSSEESDEnFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
120-395 4.68e-57

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 189.88  E-value: 4.68e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNY 199
Cdd:cd15392     1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSF-IALLILQYWPFGEFMCPVVNY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATeTVLFIVKKQEKIFCGQIWP 279
Cdd:cd15392    80 LQAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSR-LFEDSNASCGQYICTESWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLFIfgIEFVAPVITMTLCYARISRELWFKTVPGFQTE-QIRKRLRCRRKTVMVLMCILIAYVLCWAPFY 358
Cdd:cd15392   159 SDTNRYIYSLVLMI--LQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENnRDQRMAESKRKLVKMMITVVAIFALCWLPLN 236
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1443644224 359 GFTIVRDFFPTIFvKEKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd15392   237 ILNLVGDHDESIY-SWPYIPYLWLAAHWLAMSHCCYN 272
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
124-395 1.71e-56

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 341313 [Multi-domain]  Cd Length: 275  Bit Score: 187.87  E-value: 1.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 124 VALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTV 203
Cdd:cd00637     3 VLYILIFVVGVVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLG--GWWFGDALCKLLGFLQTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 204 SLYVSTNALLAIAVDRYLAIVHPLKP--RMNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVkkqekifCGQIWPVD 281
Cdd:cd00637    81 SLTASILTLTAISVDRYLAIVHPLRYrrRFTRRRAKLVIALIWLLSLLLALPPLLGWKVYDYGGY-------CCCCLCWP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 282 QQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGF---QTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFY 358
Cdd:cd00637   154 DSTLRKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRrssSNSSRRRRRRRERKVTKMLLIVVVVFLLCWLPYF 233
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1443644224 359 GFTIVRDFFPTIFvkeKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd00637   234 ILLLLDVFGPDPS---PLPRILYFLALLLAYLNSAIN 267
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
136-395 3.69e-52

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 333754 [Multi-domain]  Cd Length: 255  Bit Score: 175.96  E-value: 3.69e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 136 GNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 215
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFLLLTLPFWLVYYLHGT--WPFGSALCKLVTFLDVVNGYASILLLTAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 216 AVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATetvLFIVKKQEKIFCGQIWPVDQqmYYKSYFLFIFG 295
Cdd:pfam00001  79 SIDRYLAIVHPLRYRRIMRRAKAIILLIWVLALLLSLPPLLGWN---TLDIPSNGVTSCLITFPESL--WPVSYLLFSTV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 296 IEFVAPVITMTLCYARISRELWFKTVPGfqteqiRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRDFFPTIFVK-- 373
Cdd:pfam00001 154 LGFLLPLLVILVCYTRIIRTLRKQQSSS------IRSVRSERKALKTLLVVVVVFILCWLPYHILLLLDSLCDLGIIIsc 227
                         250       260
                  ....*....|....*....|....
gi 1443644224 374 --EKHYLTAFYIVECIAMSNSMIN 395
Cdd:pfam00001 228 evVTPPRTLLQLTVWLAYSNSCLN 251
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
120-395 5.55e-50

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 171.27  E-value: 5.55e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVrqLSWEHGHVLCASVNY 199
Cdd:cd15207     1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNIL--TGWPFGDVMCKLSPL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQIWP 279
Cdd:cd15207    79 VQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDqqMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPG---FQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAP 356
Cdd:cd15207   159 SD--EYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGggsASREAQAAVSKKKVRVIKMLIVVVVLFALSWLP 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1443644224 357 FYGFTIVRDFFPtIFVKEKH--YLTAFYIVECIAMSNSMIN 395
Cdd:cd15207   237 LHTVTMLDDFGN-LSPNQREvlYVYIYPIAHWLAYFNSCVN 276
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
129-395 2.23e-48

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 167.09  E-value: 2.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFeMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVS 208
Cdd:cd15390    10 MVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVF-NFTYLLYN-DWPFGLFYCKFSNFVAITTVAAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQIWPVDQQMYYKS 288
Cdd:cd15390    88 VFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERTVCFIAWPDGPNSLQDF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 289 -YFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRDFF 367
Cdd:cd15390   168 vYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHLYFILTYLY 247
                         250       260
                  ....*....|....*....|....*...
gi 1443644224 368 PTIFVKeKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd15390   248 PDINSW-KYIQQIYLAIYWLAMSNSMYN 274
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
120-395 2.98e-48

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 166.91  E-value: 2.98e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 199
Cdd:cd15202     1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNT--WIFGLFMCHFSNF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQIWP 279
Cdd:cd15202    79 AQYCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPG-FQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFY 358
Cdd:cd15202   159 ERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGdATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFN 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1443644224 359 GFTIVRDFFPTIFVKEKHYLtaFYIVECIAMSNSMIN 395
Cdd:cd15202   239 IYVLLLSSKPDYLIKTINAV--YFAFHWLAMSSTCYN 273
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
129-395 3.42e-43

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 153.36  E-value: 3.42e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 208
Cdd:cd15394    10 VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTL-AYAFEPRGWVFGRFMCYFVFLMQPVTVYVS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSayfATETVLFIVKKQEKIFCGQIW--PVDQQMYY 286
Cdd:cd15394    89 VFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPA---AAHTYYVEFKGLDFSICEEFWfgQEKQRLAY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 287 KSYFLFifgIEFVAPVITMTLCYARISRELWFKTVPGFQTE-QIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRD 365
Cdd:cd15394   166 ACSTLL---ITYVLPLLAISLSYLRISVKLRNRVVPGSMTQsQAEWDRARRRKTFRLLVVVVVAFAICWLPLHIFNVIRD 242
                         250       260       270
                  ....*....|....*....|....*....|
gi 1443644224 366 FFPTiFVKEKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd15394   243 IDID-LIDKQYFNLIQLLCHWLAMSSACYN 271
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
120-395 8.54e-43

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 152.11  E-value: 8.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 199
Cdd:cd15389     1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNST--WVFGKIMCHLSRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQIWP 279
Cdd:cd15389    79 AQYCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSFP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQT-EQIRKRLRCRRKTVMVLMCILIAYVLCWAPFY 358
Cdd:cd15389   159 EPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDVTtEQYVAQRRKKKKTIKMLMLVVLLFAICWLPLN 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1443644224 359 GFTIVRDFFPTifvkeKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd15389   239 CYHVLLSSHPI-----RSNSALFFAFHWLAMSSTCYN 270
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
129-395 1.54e-41

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaeastagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 149.10  E-value: 1.54e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 208
Cdd:cd15393    10 ISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQ--RWVLPRFMCPFCPFVQVLSVNVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSA-YFATETVLFIVKKQEKIFCGQIWPVDQQmyYK 287
Cdd:cd15393    88 VFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVAlALRVEELTDKTNNGVKPFCLPVGPSDDW--WK 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 288 SYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPG-FQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRDF 366
Cdd:cd15393   166 IYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGnAQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLNEI 245
                         250       260
                  ....*....|....*....|....*....
gi 1443644224 367 FPTIfVKEKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd15393   246 KPEI-NKYKYINIIWFCSHWLAMSNSCYN 273
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
121-395 3.18e-41

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 147.32  E-value: 3.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 121 VIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYL 200
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLG--YWPFGPVLCRFWIAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 201 RTVSLYVSTNALLAIAVDRYLAIVHPL--KPRMNYQTATFLIALVWTVSILVAIPSayfateTVLFIVKKQEKIFCGQIW 278
Cdd:cd14967    79 DVLCCTASILNLCAISLDRYLAITRPLryRQLMTKKRALIMIAAVWVYSLLISLPP------LVGWRDETQPSVVDCECE 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 279 PvdqqMYYKSYFLFIFGIEFVAPVITMTLCYARISRELwfktvpgfQTEqirkrlrcrRKTVMVLMCILIAYVLCWAPFY 358
Cdd:cd14967   153 F----TPNKIYVLVSSVISFFIPLLIMIVLYARIFRVA--------RRE---------LKAAKTLAIIVGAFLLCWLPFF 211
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1443644224 359 GFTIVRDFFPTIFVKEkhylTAFYIVECIAMSNSMIN 395
Cdd:cd14967   212 IIYLVSAFCPPDCVPP----ILYAVFFWLGYLNSALN 244
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
129-410 9.19e-40

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 144.35  E-value: 9.19e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVrqLSWEHGHVLCASVNYLRTVSLYVS 208
Cdd:cd15095    10 IFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYAT--PSWVFGDFMCKFVNYMMQVTVQAT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPLKpRMNYQT---ATFLIALVWTVSILVAIPSAYFATETVlfIVKKQEKIFCGQIWPvdQQMY 285
Cdd:cd15095    88 CLTLTALSVDRYYAIVHPIR-SLRFRTprvAVVVSACIWIVSFLLSIPVAIYYRLEE--GYWYGPQTYCREVWP--SKAF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 286 YKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQI--RKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIV 363
Cdd:cd15095   163 QKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQlsERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLW 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1443644224 364 RDFFPTIfvKEKHYLTAFYIVE-CIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15095   243 QRFDPNF--PETYATYALKIAAlCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
129-410 1.05e-38

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 141.46  E-value: 1.05e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 208
Cdd:cd15205    10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSN--WLGGAFMCKMVPFVQSTAVVTS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPLKPRMNY--QTATFLIALVWTVSILVAIPSAYFAT-ETVLFIVKKQEKIFCGQIWPVDQQMy 285
Cdd:cd15205    88 ILTMTCIAVERHQGIVHPLKMKWQYtnRRAFTMLGLVWIVSVIVGSPMLFVQQlEVKYDFLYEKRHVCCLERWYSPTQQ- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 286 yKSYFLFIFGIEFVAPVITMTLCYARISRELWFK----------TVPGFQTEQIrkrLRCRRKTVMVLMCILIAYVLCWA 355
Cdd:cd15205   167 -KIYTTFILVILFLLPLTTMLFLYSRIGYELWIKkrvgdasvlqTIHGIEMSKI---SRKKKRAVKMMVTVVLLFAVCWA 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1443644224 356 PFYGFTIVRDFfpTIFVKEKHYLTA---FYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15205   243 PFHVVHMMIEY--SNLENKYDGVTIkliFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
121-412 2.22e-38

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 140.12  E-value: 2.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 121 VIGVALICIMLVCG-IGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCcPFEMDYYVVRqlSWEHGHVLCASVNY 199
Cdd:cd14970     1 IVIPAVYSVVCVVGlTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLG--YWPFGEVMCKIVLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKpRMNYQT---ATFLIALVWTVSILVAIPSAYFATetvlFIVKKQEKIFCGQ 276
Cdd:cd14970    78 VDAYNMFTSIFCLTVMSVDRYLAVVHPVK-SLRFRTprkAKLVSLCVWALSLVLGLPVIIFAR----TLQEEGGTISCNL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 277 IWPVDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWfKTVPGFQTEQIRKRLRCRRKTVMVLMcILIAYVLCWAP 356
Cdd:cd14970   153 QWPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLR-SSRNLSTSGAREKRRARRKVTRLVLV-VVAVFVVCWLP 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1443644224 357 FYGFTIVR---DFFPTIFVkekhyLTAFYIVECIAMSNSMINTMCFITVKNNtmkyFKK 412
Cdd:cd14970   231 FHVFQIVRlliDPPETLTV-----VGVFLFCIALSYANSCLNPILYAFLDEN----FRK 280
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
121-395 2.83e-38

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 140.60  E-value: 2.83e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 121 VIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYL 200
Cdd:cd15208     2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTE--TWFFGQVLCKIIPYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 201 RTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFAtETVLFIVKKQEKI---FCGQI 277
Cdd:cd15208    80 QTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVM-ECSRVVPLANKTIlltVCDER 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 278 WPVDQqmYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIR--------------KRLRCRRKTVMVL 343
Cdd:cd15208   159 WSDSI--YQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRkwnkprksavaaeeKQLRSRRKTAKML 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1443644224 344 MCILIAYVLCWAPFYGFTIVRDFFPTIFVKEKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd15208   237 IVVVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFSHWLVYANSAIN 288
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
120-410 6.45e-38

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 139.18  E-value: 6.45e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 199
Cdd:cd15399     1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDE--WKFGAVLCHLVPY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQIWP 279
Cdd:cd15399    79 AQALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQACSEKWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRlrcRRKTVMVLMCILIAYVLCWAPFYG 359
Cdd:cd15399   159 NGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQR---RRKTTKMLVCVVVVFAVSWLPFHA 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1443644224 360 FTIVRDFFPTIFvKEKHYLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15399   236 FQLASDIDSKVL-DLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
136-395 6.60e-38

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 139.19  E-value: 6.60e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 136 GNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 215
Cdd:cd15391    17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGH--WVFPAPMCPIVLYVQLVSVTASVLTNTAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 216 AVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAiPSAYFATETVLFIVKKQEKIFCGQIWPvdQQMYYKS-YFLFIF 294
Cdd:cd15391    95 GIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLS-SVQLFAGRTQRYGQYSEGRVLCGESWP--GPDTSRSaYTVFVM 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 295 GIEFVAPVITMTLCYARISRELWFKTVPGFQTEQI-RKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRDfFPTIFVK 373
Cdd:cd15391   172 LLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRdDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQD-FSTVFRN 250
                         250       260
                  ....*....|....*....|....
gi 1443644224 374 EKHYLT--AFYIVECIAMSNSMIN 395
Cdd:cd15391   251 MPQHTTrlIYGACHWIAMSNSFVN 274
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
129-410 1.47e-36

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 135.29  E-value: 1.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 208
Cdd:cd14971    10 IFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLP--GWVFGDFMCKFVHYFQQVSMHAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPL--KPRMNYQTATFLIALVWTVSILVAIPSAYFATetvLFIVKKQEKIFCGQIWPvdQQMYY 286
Cdd:cd14971    88 IFTLVAMSLDRFLAVVYPLrsLHIRTPRNALAASGCIWVVSLAVAAPVLALHR---LRNYTPGNRTVCSEAWP--SRAHR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 287 KSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRkrlRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRDF 366
Cdd:cd14971   163 RAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR---RAKRKVTRLVLVVVVLFAACWGPIHAILLLVAL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1443644224 367 FPTIFVKEKHYLTAFyiVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd14971   240 GPFPLTYATYALRIW--AHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
121-395 2.10e-36

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 135.20  E-value: 2.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 121 VIGVALICIMLVCGI-GNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 199
Cdd:cd14986     1 VSRVAVLGVLFVFTLvGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGE--WVAGDVLCRIVKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYfatetvLFIVKKQEKIF--CGQI 277
Cdd:cd14986    79 LQVVGLFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLV------IFVERELGDGVhqCWSS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 278 WPvdQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELW-----FKTVPGFQTEQIRKRLRCRR-----------KTVM 341
Cdd:cd14986   153 FY--TPWQRKVYITWLATYVFVIPLIILSYCYGRILRTIWirsrqKTDRPIAPTAMSCRSVSCVSsrvslisrakiKTIK 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1443644224 342 VLMCILIAYVLCWAPFYGFTIVRDFFPTIFVKEkhylTAFYIVECIAMSNSMIN 395
Cdd:cd14986   231 MTLVIILAFILCWTPYFIVQLLDVYAGMQQLEN----DAYVVSETLASLNSALN 280
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
129-400 1.33e-35

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 132.40  E-value: 1.33e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVrqLSWEHGHVLCASVNYLRTVSLYVS 208
Cdd:cd15001     9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFS--PTWSLGAFLCKAVAYLQLLSFICS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPLKPRM--NYQTATFLIALVWTVSILVAIPSAyFATETVLFIVKKQEKIF-CGQIWPvdQQMY 285
Cdd:cd15001    87 VLTLTAISIERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPVL-FGQGLVRYESENGVTVYhCQKAWP--STLY 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 286 YKSYFLFIFGIEFVAPVITMTLCYARIsrelwfktvpgfqteqirkrlrcRRKTVMV-LMCILIAYVLCWAPFYGFTIVR 364
Cdd:cd15001   164 SRLYVVYLAIVIFFIPLIVMTFAYARD-----------------------TRKQVIKmLISVVVLFAVCWGPLLIDNLLV 220
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1443644224 365 DFfptIFVKEKHYLTAFYIV---ECIAMSNSMINTMCFI 400
Cdd:cd15001   221 SF---DVISTLHTQALKYMRiafHLLSYANSCINPIIYA 256
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-399 4.33e-34

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 128.89  E-value: 4.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 124 VALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 203
Cdd:cd16003     5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSE--WYFGEAYCRFHNFFPIT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 204 SLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLfivkkQEKIFCGQIWPVDQQ 283
Cdd:cd16003    83 SVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVM-----PGRTLCFVAWPGGPD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 284 MYYKSYFLFIFgIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTIV 363
Cdd:cd16003   158 QHFTYHIIVIV-LVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIV 236
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1443644224 364 RDFFPTIfVKEKHYLTAFYIVECIAMSNSMINTMCF 399
Cdd:cd16003   237 TGLYQQL-NRWKYIQQVYLASFWLAMSSTMYNPIIY 271
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
120-410 7.82e-34

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 127.92  E-value: 7.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKL--RNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASV 197
Cdd:cd15098     1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLP--EWVFGAFMCKFV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 198 NYLRTVSLYVSTNALLAIAVDRYLAIVHPLKPR--MNYQTATFLIALVWTVSILVAIPSAYfaTETVLFIVKKQEKIFCG 275
Cdd:cd15098    79 HYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSslRTRRNALLGVLVIWVLSLAMASPVAV--HQDLVHHWTASNQTFCW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 276 QIWPVDQQmyYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTvpgfqTEQIRKRLRCRRKTVMVLMCILIAYVLCWA 355
Cdd:cd15098   157 ENWPEKQQ--KPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKL-----KNMSKKSERSKKKTAQTVLVVVVVFGISWL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1443644224 356 PFYGFTIVRDF--FP---TIFVkekhyltaFYIV-ECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15098   230 PHHIIHLWVEFgdFPltqASFV--------LRITaHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
124-412 3.38e-33

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519  Cd Length: 293  Bit Score: 126.78  E-value: 3.38e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 124 VALICIMLVCG-IGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFE-----MDYyvvrqlsWEHGHVLCASV 197
Cdd:cd15397     4 VVSYSLVMAVGlLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTvvytlMDY-------WIFGEVLCKMT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 198 NYLRTVSLYVSTNALLAIAVDRYLAIVHPL--KPRMNYqtATFLIALVWTVSILVAIPSAYFATET-------VLFIVKK 268
Cdd:cd15397    77 PFIQCMSVTVSILSLVLIALERHQLIINPTgwKPSVSQ--AYLAVVVIWMLACFISLPFLAFHILTdepyknlSHFFAPL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 269 QEKIFCGQIWPVDQQMYYKSYFLFIFgiEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRLRCRRKTVMVLMCILI 348
Cdd:cd15397   155 ADKAVCTESWPSEHHKLAYTTWLLLF--QYCLPLLFILVCYLRIYLRLRRRKDMLERRGEYNRRAGHSKRINVMLVSLVA 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1443644224 349 AYVLCWAPFYGFTIVRDFFPTIFVKEKHYLTaFYIVECIAMSNSMINTMCFITVKNNtmkyFKK 412
Cdd:cd15397   233 AFALCWLPLNVFNAIADWNHEAIPHCQHNLI-FSLCHLAAMASTCVNPIIYGFLNSN----FKK 291
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
121-395 4.20e-33

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 126.23  E-value: 4.20e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 121 VIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYL 200
Cdd:cd15927     2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLD--SWPFGEFLCKLSEFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 201 RTVSLYVSTNALLAIAVDRYLAIVHPLkpRMNYQTATFLIAL----VWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQ 276
Cdd:cd15927    80 KDTSIGVSVFTLTALSADRYFAIVNPM--RKHRSQATRRTLVtaasIWIVSILLAIPEAIFSHVVTFTLTDNQTIQICYP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 277 IWPVDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELW--FKTVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCW 354
Cdd:cd15927   158 YPQELGPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIrsTRNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCW 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1443644224 355 APFYGFTIVRDFFPTIFVKEKHYLTAFYIVE-CIAMSNSMIN 395
Cdd:cd15927   238 LPRHVFMLWFHFAPNGLVDYNAFWHVLKIVGfCLSFINSCVN 279
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-395 2.31e-31

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 121.49  E-value: 2.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 124 VALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYyvVRQLSWEHGHVLCASVNYLRTV 203
Cdd:cd16004     5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVY--ASHNDWYFGLEFCRFQNFFPIT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 204 SLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATetvlfIVKKQEKIFCGQIWPVDQQ 283
Cdd:cd16004    83 AMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYST-----VTMDQGRTKCIVAWPGDSG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 284 MYYK-SYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQ-TEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFT 361
Cdd:cd16004   158 GKHQlTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQaHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYF 237
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1443644224 362 IVRDFFPTIFVK---EKHYLTAFYivecIAMSNSMIN 395
Cdd:cd16004   238 ILGSFNEDIYCQkyiQQVYLAIFW----LAMSSTMYN 270
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
125-395 1.35e-30

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320  Cd Length: 284  Bit Score: 119.41  E-value: 1.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 125 ALICIMLVCGI-GNLIFIAALARYKKLRNLTNLLIANLAISDFIVaIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTV 203
Cdd:cd14985     5 ALYIAIFLVGLlGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF-VLTLPLWATYTA-NQYDWPFGAFLCKVSSYVISV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 204 SLYVSTNALLAIAVDRYLAIVHPLK--PRMNYQTATFLIALVWTVSILVAIPSAYFATetvLFIVKKQEKIFCGQIWPVD 281
Cdd:cd14985    83 NMFASIFLLTCMSVDRYLAIVHPVAsrRLRRRRQARVTCALIWVVACLLSLPTFLLRS---LQAIENLNKTACIMLYPHE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 282 QQMYYKSYFLFIFGieFVAPVITMTLCYARISRELWFKtvpgfqTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFT 361
Cdd:cd14985   160 AWHFGLSLELNILG--FVLPLLIILTCYFHIARSLRKR------YERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFK 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1443644224 362 ---------IVRDFFPTIFVKekhylTAFYIVECIAMSNSMIN 395
Cdd:cd14985   232 fldflaqlgAIRPCFWELFLD-----LGLPIATCLAFTNSCLN 269
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-399 1.39e-30

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 119.20  E-value: 1.39e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 124 VALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 203
Cdd:cd16002     5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNE--WYYGLEYCKFHNFFPIA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 204 SLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFivkkqEKIFCGQIWP-VDQ 282
Cdd:cd16002    83 AVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMP-----GRVVCYVEWPeHEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 283 QMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGFQTEQIRKRLRCRRKTVMVLMCILIAYVLCWAPFYGFTI 362
Cdd:cd16002   158 RKYETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFL 237
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1443644224 363 VRDFFPTIFvkEKHYLTAFYI-VECIAMSNSMINTMCF 399
Cdd:cd16002   238 LQYFHPELY--EQKFIQQVYLaIMWLAMSSTMYNPIIY 273
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
120-408 3.44e-30

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 117.94  E-value: 3.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDfIVAIVCCPFeMDYYVVRQLSWEHGHVLCASVNY 199
Cdd:cd15088     1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVAD-LLFMLGMPF-LIHQFAIDGQWYFGEVMCKIITA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKpRMNYQT---ATFLIALVWTVSILVAIPSAYFATetvlFIVKKQEKIFCGQ 276
Cdd:cd15088    79 LDANNQFTSTYILTAMSVDRYLAVVHPIR-STKYRTrfvAKLVNVGLWAASFLSILPVWVYSS----LIYFPDGTTFCYV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 277 IWPVDQQMYYKSYFLFIFGieFVAPVITMTLCYARISRELWFKTVPGFQTEQirkRLRCRRKTVMVLmCILIAYVLCWAP 356
Cdd:cd15088   154 SLPSPDDLYWFTIYHFILG--FAVPLVVITVCYILILHRLARGVAPGNQSHG---SSRTKRVTKMVI-LIVVVFIVCWLP 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1443644224 357 FY--GFTIVRDFFPTIfvkekHYLTAFYIVECIAMSNSMINTMCFITVKNNTMK 408
Cdd:cd15088   228 FHvvQLVNLAMNRPTL-----AFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
129-400 4.64e-30

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 117.49  E-value: 4.64e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 129 IMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVS 208
Cdd:cd15206    10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIF--GEVMCKLIPYFQAVSVSVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 209 TNALLAIAVDRYLAIVHPLKPRMnYQT---ATFLIALVWTVSILVAIPSAYFaTETVLFIVKKQEKifCGQIWPVDQqmY 285
Cdd:cd15206    88 TFTLVAISLERYFAICHPLKSRV-WQTlshAYKVIAGIWLLSFLIMSPILVF-SNLIPMSRPGGHK--CREVWPNEI--A 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 286 YKSYFLFIFGIEFVAPVITMTLCYARISRELWfktvpgfqteqirkrlRCRRKTVMVLMCILIAYVLCWAPFYGFTIVRD 365
Cdd:cd15206   162 EQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL----------------EAKKRVIRMLFVIVVEFFICWTPLYVINTWKA 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1443644224 366 FFPTIfVKEKHYLTAFYIVECIAMSNSMIN--TMCFI 400
Cdd:cd15206   226 FDPPS-AARYVSSTTISLIQLLAYISSCVNpiTYCFM 261
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
114-395 5.92e-30

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 117.40  E-value: 5.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 114 TFFAAKIVIGValicimlvcgIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVL 193
Cdd:cd15096     5 VIFGLIFIVGL----------IGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPT--WPFGDVW 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 194 CASVNYLRTVSLYVSTNALLAIAVDRYLAIVHPLKPRM--NYQTATFLIALVWTVSILVAIPSAyFATETVLFIVKKQEK 271
Cdd:cd15096    73 CKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVL-FLHGVVSYGFSSEAY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 272 IFCGQIWPVDQ--QMYYKSYFLFifgiEFVAPVITMTLCYARISRELWFKTVPGFQ--TEQIRKRlrcRRKTVMVLmCIL 347
Cdd:cd15096   152 SYCTFLTEVGTaaQTFFTSFFLF----SYLIPLTLICVLYMLMLRRLRRQKSPGGRrsAESQRGK---RRVTRLVV-VVV 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1443644224 348 IAYVLCWAPfygftIVRDFFPTIFVKEKHylTAFYIV-----ECIAMSNSMIN 395
Cdd:cd15096   224 VVFAICWLP-----IHIILLLKYYGVLPE--TVLYVViqilsNCLAYGNSCVN 269
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
125-395 2.30e-29

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 115.77  E-value: 2.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 125 ALICIMLVCG-IGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCcPFEMDYYVVrqlSWEHGHVLCASVNYLRTV 203
Cdd:cd14984     5 VLYSLVFLLGlVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTL-PFWAVYAAD---GWVFGSFLCKLVSALYTI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 204 SLYVSTNALLAIAVDRYLAIVHPLkPRMNYQTATFLI---ALVWTVSILVAIPSAYFATetvlfiVKKQEKIF-CGQIWP 279
Cdd:cd14984    81 NFYSGILFLACISIDRYLAIVHAV-SALRARTLLHGKltcLGVWALALLLSLPEFIFSQ------VSEENGSSiCSYDYP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMYYKSYFLF---IFGieFVAPVITMTLCYARISRELwfktvpgfqteqIRKRLRCRRKTVMVLMCILIAYVLCWAP 356
Cdd:cd14984   154 EDTATTWKTLLRLlqnILG--FLLPLLVMLFCYSRIIRTL------------LRARNHKKHRALRVIFAVVVVFFLCWLP 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1443644224 357 FYGFTIVRDFFPTIFVK-----EKHYLTAFYIVECIAMSNSMIN 395
Cdd:cd14984   220 YNIVLLLDTLQLLGIISrscelSKSLDYALQVTESLAFSHCCLN 263
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
120-356 2.76e-29

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 320100 [Multi-domain]  Cd Length: 284  Bit Score: 115.77  E-value: 2.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQLSWehGHVLCASVNY 199
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVILVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSF--GDPGCVIYGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIVHPLKP-RMNYQTATFLIALVWTVSILVAIP-----SAYfatetvlfiVKKQEKIF 273
Cdd:cd14969    79 AVTFLGLVSISTLAALAFERYLVIVRPLKAfRLSKRRALILIAFIWLYGLFWALPplfgwSSY---------VPEGGGTS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 274 CGQIWpVDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVP---GFQTEQIRKRLRCRRKTVMVLMCILIAY 350
Cdd:cd14969   150 CSVDW-YSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRaarRKNSAITKRTKKAEKKVAKMVLVMIVAF 228

                  ....*.
gi 1443644224 351 VLCWAP 356
Cdd:cd14969   229 LIAWTP 234
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
125-368 1.08e-28

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 113.76  E-value: 1.08e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 125 ALICIMLVCGigNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQLSWehGHVLCASVNYLRTVS 204
Cdd:cd15979     8 SVIFLLSVFG--NMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIF--GEVICKAVAYLMGVS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 205 LYVSTNALLAIAVDRYLAIVHPLKPRMnYQT---ATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCGQIWPVD 281
Cdd:cd15979    84 VSVSTFSLVAIAIERYSAICNPLQSRV-WQTrshAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAWPSA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 282 QqmYYKSYFLFIFGIEFVAPVITMTLCYARISRELWfktvpgfqteqirKRLRCRRKTVMVLMCILIAYVLCWAPFYGFT 361
Cdd:cd15979   163 Q--VRQAWYVLLLLILFFIPGVVMIVAYGLISRELY-------------RGLLAKKRVIRMLVVIVAMFFLCWLPIFSAN 227

                  ....*..
gi 1443644224 362 IVRDFFP 368
Cdd:cd15979   228 TWRAFDP 234
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
125-410 4.23e-28

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 112.18  E-value: 4.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 125 ALICIMLVCGIGNLIFIaaLARYKKLRNLTNLLIANLAISD--FIVAIvccPFEMdyYVVRQLSWEHGHVLCASVNYLRT 202
Cdd:cd15094     8 GLICIVGLVGNGLVIYV--VLRYAKMKTVTNLYILNLAVADecFLIGL---PFLI--VTMILKYWPFGAAMCKIYMVLTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 203 VSLYVSTNALLAIAVDRYLAIVHPLKPrMNYQT---ATFLIALVWTVSILVAIPSAYFATETVLFIVKKqekifCGQIWP 279
Cdd:cd15094    81 INQFTSSFTLTVMSADRYLAVCHPIRS-MRYRTpfiAKVVCATTWSISFLVMLPIILYASTVPDSGRYS-----CTIVWP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 280 VDQQMY-YKSYFLFIFGIEFVAPVITMTLCYARISRELwfKTVpGFQTEQIRKRLRCRRKTVMVLMCILIaYVLCWAPFY 358
Cdd:cd15094   155 DSSAVNgQKAFTLYTFLLGFAIPLLLISVFYTLVILRL--RTV-GPKNKSKEKRRSHRKVTRLVLTVISV-YIICWLPYW 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1443644224 359 GFTIVRDFFPTIFVKEKHYLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15094   231 AFQVHLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
125-410 4.26e-28

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 112.17  E-value: 4.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 125 ALICIMLVCGigNLIFIAALARYKKLRNLTNLLIANLAISD--FIVAIvccPFEMDYYVVRQlsWEHGHVLCASVNYLRT 202
Cdd:cd15093     8 AVVCLVGLCG--NSLVIYVVLRYAKMKTVTNIYILNLAIADelFMLGL---PFLAASNALRH--WPFGSVLCRLVLSVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 203 VSLYVSTNALLAIAVDRYLAIVHPLK------PRmnyqTATFLIALVWTVSILVAIPSAYFATETvlfiVKKQEKIFCGQ 276
Cdd:cd15093    81 INMFTSIFCLTVMSVDRYLAVVHPIKsarwrrPR----VAKVVNLAVWVASLLVILPVVVFAGTR----ENQDGSSACNM 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 277 IWPVDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELwfKTVPGFQTEQIRKRLRcRRKTVMVLMcILIAYVLCWAP 356
Cdd:cd15093   153 QWPEPAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKV--KSAGLRAGWQQRKRSE-RKVTRMVVM-VVVVFVICWLP 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1443644224 357 FYGFTIVRDFFPtiFVKEKHYLTAFYIVECIAMSNSMINTMCFITVKNNTMKYF 410
Cdd:cd15093   229 FYVLQLVNVFVQ--LPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
120-369 9.99e-28

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 111.36  E-value: 9.99e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 120 IVIGVALICIMLVCgIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 199
Cdd:cd14977     2 VIMSLSLVIFAVGI-IGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKD--WLFGDVMCKLVPF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 200 LRTVSLYVSTNALLAIAVDRYLAIV--HPLKPRMNYQTATFLIALVWTVSILVAIPSAYFATETVLFIVKKQEKIFCG-Q 276
Cdd:cd14977    79 IQVTSLGVTVFSLCALSIDRYRAAVnsMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCImK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 277 IWPVDQQMYYKSYFLFIFGIEFVAPVITMTLCYARISRELWFKTVPGfqTEQIRKRLRCRRKTVMVLMCILIAYVLCWAP 356
Cdd:cd14977   159 PSTPFAETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEY--TRGTKKHMKQRRQLAKTVLCLVLVFAFCWLP 236
                         250
                  ....*....|...
gi 1443644224 357 FYGFTIVRDFFPT 369
Cdd:cd14977   237 EHISNILRATLYN 249
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
119-395 1.74e-27

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 110.02  E-value: 1.74e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 119 KIVIGV-ALICIMLVcgIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIvccpfemdYYVVRQLSWEHGH------ 191
Cdd:cd15196     1 KVEIAVlATILVLAL--FGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAL--------FNVLPQLIWDITYrfyggd 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 192 VLCASVNYLRTVSLYVSTNALLAIAVDRYLAIVHPLKP-RMNYQTATFLIALVWTVSILVAIPSayfatetvLFIVKKQE 270
Cdd:cd15196    71 LLCRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPQ--------LFIFSYQE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 271 kIFCGQ--IWPVDQQMY-YKSYFLFIFGIEFVAPVITMTLCYARISRELWfktvpgfqteqirkrlRCRRKTVMVLMCIL 347
Cdd:cd15196   143 -VGSGVydCWATFEPPWgLRAYITWFTVAVFVVPLIILAFCYGRICYVVW----------------RAKIKTVKLTLVVV 205
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1443644224 348 IAYVLCWAPFYGFTIVRDFFPTIFVKEkhylTAFYIVECIAMSNSMIN 395
Cdd:cd15196   206 ACYIVCWTPFFVVQMWAAWDPTAPIEG----PAFVIIMLLASLNSCTN 249
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
118-395 1.97e-27

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in nuemerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 110.60  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 118 AKIVIgvaLICIMLVCGIGNLIFIAALARYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDY-YVVrqlSWEHGHVLCAS 196
Cdd:cd15384     2 LKIVV---LAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWaYTV---AWLAGNTMCKL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 197 VNYLRTVSLYVSTNALLAIAVDRYLAIVHPLKPRMNYQTATFLIALVWTVSILVAIPSAY-FATETVLFIVKKQEKI--- 272
Cdd:cd15384    76 VKYLQVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAViFHVERGPFVEDFHQCVtyg 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 273 FCGQIWpvDQQMYYKSYFLFIfgieFVAPVITMTLCYARISRELwFKTVPGFQTE--------QIRKRL--RCRRKTVMV 342
Cdd:cd15384   156 FYTAEW--QEQLYNMLSLVFM----FPIPLVIMVTCYVLIFITL-SKSSRDFQGLeiytrnrgPNRQRLfhKAKVKSLRM 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1443644224 343 LMCILIAYVLCWAPFYGFTIVRDFFPTIFVKEKHYLTAFYivecIAMSNSMIN 395
Cdd:cd15384   229 SAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIFF----FGMSNSCVN 277
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
121-362 2.72e-27

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 110.19  E-value: 2.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 121 VIGVALICIMLVCGIGNLIFIAALA--RYKKLRNLTNLLIANLAISDFIVAIVCCPFEMDYYVVRqlSWEHGHVLCASVN 198
Cdd:cd15002     1 LVPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKG--SWPLGWFVCKTAD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 199 YLRTVSLYVSTNALLAIAVDRYLAIVHPLKPR-MNYQTATFLIALVWTVSILVAIPSAYFATetvlfIVKKQEKIFCGQI 277
Cdd:cd15002    79 WFGHACMAAKSFTIAVLAKACYMYVVNPTKQVtIKQRRITAVVASIWVPACLLPLPQWLFRT-----VKQSEGVYLCILC 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443644224 278 WPV----DQQMYYKSYF