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Conserved domains on  [gi|975098749|ref|XP_015264389|]
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PREDICTED: transmembrane protein 132C-like, partial [Gekko japonicus]

Protein Classification

TMEM132 and TMEM132D_C domain-containing protein (domain architecture ID 11756457)

TMEM132 and TMEM132D_C domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
185-269 6.90e-51

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 318007  Cd Length: 84  Bit Score: 165.19  E-value: 6.90e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975098749  185 TNFPAQIDLPKNDGsMDDSDLVQAPRGLSDLEIGMYALLGVFCLAILVFLINCATFTLKYRHKQVPVEGQATMSHSHDWV 264
Cdd:pfam15706   1 TNFPAQTEAPGNNG-VGESDLVQAPRGLTDLEIGMYALLGVFCLAILVFLINCVVFALKYRRKKSPVEGQGPVPHSHDWV 79

                  ....*
gi 975098749  265 WLGNE 269
Cdd:pfam15706  80 WLGTE 84
TMEM132 super family cl25648
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
1-73 2.63e-31

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


The actual alignment was detected with superfamily member pfam16070:

Pssm-ID: 339594  Cd Length: 342  Bit Score: 121.57  E-value: 2.63e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975098749    1 EAILSSWIQFSDGSVTPLDIYDPKDFSLSASSLDESVVSAHLSSTTKWPVVAAEGEGQGMLVKVDMMISEACQ 73
Cdd:pfam16070 270 EALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVAQDAASSWPVVVAEGEGQGPLLRVELLISEACQ 342
 
Name Accession Description Interval E-value
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
185-269 6.90e-51

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 318007  Cd Length: 84  Bit Score: 165.19  E-value: 6.90e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975098749  185 TNFPAQIDLPKNDGsMDDSDLVQAPRGLSDLEIGMYALLGVFCLAILVFLINCATFTLKYRHKQVPVEGQATMSHSHDWV 264
Cdd:pfam15706   1 TNFPAQTEAPGNNG-VGESDLVQAPRGLTDLEIGMYALLGVFCLAILVFLINCVVFALKYRRKKSPVEGQGPVPHSHDWV 79

                  ....*
gi 975098749  265 WLGNE 269
Cdd:pfam15706  80 WLGTE 84
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
1-73 2.63e-31

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 339594  Cd Length: 342  Bit Score: 121.57  E-value: 2.63e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975098749    1 EAILSSWIQFSDGSVTPLDIYDPKDFSLSASSLDESVVSAHLSSTTKWPVVAAEGEGQGMLVKVDMMISEACQ 73
Cdd:pfam16070 270 EALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVAQDAASSWPVVVAEGEGQGPLLRVELLISEACQ 342
 
Name Accession Description Interval E-value
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
185-269 6.90e-51

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 318007  Cd Length: 84  Bit Score: 165.19  E-value: 6.90e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975098749  185 TNFPAQIDLPKNDGsMDDSDLVQAPRGLSDLEIGMYALLGVFCLAILVFLINCATFTLKYRHKQVPVEGQATMSHSHDWV 264
Cdd:pfam15706   1 TNFPAQTEAPGNNG-VGESDLVQAPRGLTDLEIGMYALLGVFCLAILVFLINCVVFALKYRRKKSPVEGQGPVPHSHDWV 79

                  ....*
gi 975098749  265 WLGNE 269
Cdd:pfam15706  80 WLGTE 84
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
1-73 2.63e-31

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 339594  Cd Length: 342  Bit Score: 121.57  E-value: 2.63e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975098749    1 EAILSSWIQFSDGSVTPLDIYDPKDFSLSASSLDESVVSAHLSSTTKWPVVAAEGEGQGMLVKVDMMISEACQ 73
Cdd:pfam16070 270 EALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVAQDAASSWPVVVAEGEGQGPLLRVELLISEACQ 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.17
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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