Conserved Protein Domain Family
DUF21

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pfam01595: DUF21 
Domain of unknown function DUF21
This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to Brachyspira hyodysenteriae hemolysin C that does not contain this domain. This domain is found in the N-terminus of the proteins adjacent to two intracellular CBS domains pfam00571.
Statistics
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PSSM-Id: 396256
Aligned: 89 rows
Threshold Bit Score: 42.9693
Threshold Setting Gi: 152030362
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q113I5            25 LLVFLLI-TINAFFVLAEFSIVSVRRSRINQLVDAGDVQAKI--VQQLQRHIERLLSTTQLGITLSSFTLGWIGAKT--M 99  Trichodesmi...
WP_012370973       9 FIWFFVLlVISAFFSSSETALSSANRLRILHQSEEGSRRATQ--ALRLLQRYEETLTAILIGNTLSNLGVAMIGGWL--A 84  Exiguobacte...
Q5L2B7             9 FGWFFLSlLANALFASAEAAFSSASKARLRHYAEEH-LHNKR--LQAVIGQLDRVLLALAVANRLTSVVTVVLFTDI--A 83  Geobacillus...
jgi:Haur_4588     11 GL-AMCL-IIVSVASAAEAALSTISRHRMNTLLENGERRANV--AMRLLEDPYHLRIGTLLLSTVGTIGATALLLTF--V 84  Herpetosiph...
Q47RN3            12 GLAVLLI-CGAAFFVAAETAFSRTVRLGGKAPSRDH-SATRR--LRRVAADPAYHLNTALLLRVCCEVGATLAL-----A 82  Thermobifid...
Q31RV0             6 IATLVVL-LGSAICSASEAALLSLPLIRVRQLAESRRPAALA--LLAIKEQISRPLAALVVLNNLFNILGSIIIGSL--A 80  Synechococc...
WP_012474993       5 LVYFFLAlGVSFMCSILESVLLSTNMSYVSILEKEKPNVGAL--LKHHKVNLNKSIASILILNTIANTLGAAGVGAQ--A 80  Chlorobium ...
Q093U4             8 AACLALC-FLRSLVAAAESALYGTSDLRAQELAETSGRAGRR--VLRHKTEREATATALRLGMVLSGFLAAAIGAFVppr 84  Stigmatella...
jgi:Anae109_3952  13 ASAAALL-AVRALVAALEAALVAVGTPRAQELAADPSAGPQAraLASLLAEPEITAFTLRATVTFATVFAGVLAAAAgaA 91  Anaeromyxob...
jgi:Mmc1_0450      4 LLTLLLLlFLSGFFSGSETALTALSHARVESLMLERRPGAKA--LYRLKLNTDRMLITLLIGNNLVNIAASAIATVF--A 79  Magnetococc...
Q113I5           100 VEIVtnaiktiplpihigqgndDSVAITIVT---FLIlAYLQIVLGELCPKSVALIYSEQLSRLLGPLSIAISRLFNPFI 176 Trichodesmi...
WP_012370973      85 MTVS------------------TDLLVQISI---VFLtFLFILLFGELIPKSYAREHAETYVFWISGPLHVCLSLFKPAI 143 Exiguobacte...
Q5L2B7            84 VSLLg-----------------EQMGLFATL---AVM-TVLFVVFGEILPKSMAKEHAEQLAIRYAGLAYGLMKLMTPVT 142 Geobacillus...
jgi:Haur_4588     85 ANR-------------------TGWQQASFL---LIF-LLVWLTIGTTLPKTLATAYPDSMVLWTVRPLRILLWLVAPMQ 141 Herpetosiph...
Q47RN3            83 VGFLtwl-------------glTWGAVALTA---VVT-VLVDYVLVGVIPRILARRFPGPTAEVAAAVVGPATVVLGPVA 145 Thermobifid...
Q31RV0            81 AQVL------------------QSAWIGIFS---AVL-TLLIILFGEIVPKTLGTRFAQTLALVSAQPLRWLTRLLLPII 138 Synechococc...
WP_012474993      81 AHIYg-----------------SDIVVYVS----VVL-TFGILFFSEIIPKTIGALYWKELSTITAYAIHVFIWITYPLI 138 Chlorobium ...
Q093U4            85 mld--------------fnrlgDDAWLPVATvaaGALfVGVVATLLDVTMRGLANASAERWALRLSGLVSVLVFFFYPPM 150 Stigmatella...
jgi:Anae109_3952  92 IAPGspwl----------------------agvgIAAgAVLLSLPLAAGARGLGAAHGETVALALAPPFRLLRRIARPFA 149 Anaeromyxob...
jgi:Mmc1_0450     80 TEQF------------------GHLGPGLAV---GGL-TLFILIFGEIVPKTFAARNMVSIALVVAPPLYLFAQAVFPLT 137 Magnetococc...
Q113I5           177 ----WI---LNQSTYWLL-RLLGIRstGSAWKAPVTSEELQLIISTSTES-----IGLEAEE 225 Trichodesmium erythraeum IMS101
WP_012370973     144 ----FLflkLRQVALLLIg--------ADPKGPLVTEQELRALVDISEEE-----GVMDEAG 188 Exiguobacterium sibiricum
Q5L2B7           143 aslqAL---KDRIAKRFA---------NGVAVPAVTEEDIKVMVELSEEE-----GVIDNKE 187 Geobacillus kaustophilus
jgi:Haur_4588    142 ----WL---LRQIARPIGlV-------TGQHPLIVTEEELKLMVNVGEEE-----GVIEAEE 184 Herpetosiphon aurantiacus DSM...
Q47RN3           146 ----RL---LVRAGQLLL-PRGGTD----REGPFATEEELRHLVDLAERG-----HVIDPEE 190 Thermobifida fusca YX
Q31RV0           139 ----WL---LEHFTAPFN---------EGSPQLTTDEQEIQLLASIGHQE-----GAIEQDE 179 Synechococcus elongatus PCC 7942
WP_012474993     139 ----YL---TLFVTDKMSk--------SKKNVSRMSRAELLASALLGEHE-----GVIDEKE 180 Chlorobium phaeobacteroides
Q093U4           151 ----RL---VMALLNLVV-RTFGRT--LRFEAPPPPLEELEKLLAAQAAN-----NEVDKSA 197 Stigmatella aurantiaca DW4/3-1
jgi:Anae109_3952 150 ----AV---VGLLAGKRA----------RFSNPPPPLDEMERALSEYARVhgvagGGA--TT 192 Anaeromyxobacter sp. Fw109-5
jgi:Mmc1_0450    138 ----WL---LEHITQSLQr-------fSRQSEPTVTESELLTLASHGARE-----GAIEADE 180 Magnetococcus marinus MC-1
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