Conserved Protein Domain Family

cl21504: EGF_CA Superfamily 
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Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Taxonomy: root
PubMed: 23 links
Protein: Related Protein
Related Structure
Accession: cl21504
PSSM Id: 419698
Name: EGF_CA
Created: 5-Sep-2014
Updated: 24-Nov-2020
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