Conserved Protein Domain Family

cl10935: PEN-2 Superfamily 
Presenilin enhancer-2 subunit of gamma secretase
This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.
Taxonomy: Eukaryota
Accession: cl10935
PSSM Id: 416005
Name: PEN-2
Created: 25-Nov-2008
Updated: 24-Nov-2020
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