Conserved Protein Domain Family

cl06362: DPM2 Superfamily 
Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
This family consists of several eukaryotic dolichol phosphate-mannose biosynthesis regulatory (DPM2) proteins. Biosynthesis of glycosylphosphatidylinositol and N-glycan precursor is dependent upon a mannosyl donor, dolichol phosphate-mannose (DPM). DPM2, an 84 amino acid membrane protein expressed in the endoplasmic reticulum (ER), makes a complex with DPM1 that is essential for the ER localization and stable expression of DPM1. Moreover, DPM2 enhances binding of dolichol phosphate, a substrate of DPM synthase. Biosynthesis of DPM in mammalian cells is regulated by DPM2.
Taxonomy: Eukaryota
Accession: cl06362
PSSM Id: 414745
Name: DPM2
Created: 8-Feb-2008
Updated: 24-Nov-2020
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