4X96


Conserved Protein Domain Family
LCAT

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pfam02450: LCAT 
Lecithin:cholesterol acyltransferase
Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.
Statistics
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PSSM-Id: 396835
Aligned: 8 rows
Threshold Bit Score: 422.729
Threshold Setting Gi: 75350323
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4X96_A        39 TIWLD-LNMFLPLGVD--CWIDntRVVYNRSSGLvsNAPGVQI---RVP-GFgktYSVEYLdsskLA----G--Y--LHT 103
P40345       206 RLWGS-FYMLRTMVMDkvCWLK--HVMLDPETGL--DPPNFTL---RAAqGF---ESTDYF----IA----G--YwiWNK 264 Saccharomyces c...
Q4VCM1        74 LVWLD-TTKLLSAVN---CWFK--CMVLDPYNQT--DHPECKS---RPDsGL---SAITELdpgyIT----GplStvWKE 135 thale cress
Q59208       250 EIWLGlWDMGVGIRDPrhRRILslEPVKNGSVNVqpRQPGIKVfpeRADgGF---RAIEYLsytkLDldviKkqVeqYAS 326 Bacillus lichen...
Q21515        71 DLWLN-LQLFTPLVID--CWADnmQLVFNTTTGLseNMPGVDI---RVA-GFgatESVEWLdkskAS----QgrY--FFD 137 Caenorhabditis ...
P53760        81 TIWLN-LNTFLPVGVD--CWIDntRVVYNRTARKmtNAPGVHI---RVP-GFgktYSVEYLdqskLA----G--Y--LHT 145 chicken
XP_009429354  83 TIWLD-LNMFLPLGVD--CWIDntRVVYNRSSGLvsNAPGVQI---RVP-GFgktYSVEYLdsskLA----G--Y--LHT 147 chimpanzee
O94680       175 RLWGS-WSMLKAMFLDkqCWLE--HLMLDKKTGL--DPKGIKL---RAAqGF---EAADFF----IT----G--YwiWSK 233 Schizosaccharom...
4X96_A       104 LVQNLVNNGYVRDEtVRAAPYDWRLE---PGQQEEYYRKLAGLVEEMHA-AYGKPVFLIGHSLGCLHLLYFLLR-QPQA- 177
P40345       265 VFQNLGVIGYEPNK-MTSAAYDWRLAyldLERRDRYFTKLKEQIELFHQ-LSGEKVCLIGHSMGSQIIFYFMKWvEAEGp 342 Saccharomyces c...
Q4VCM1       136 WLKWCVEFGIEANA-IVAVPYDWRLSptkLEERDLYFHKLKLTFETALK-LRGGPSIVFAHSMGNNVFRYFLEWlRLEIa 213 thale cress
Q59208       327 MAKHLEKMGYRKNRtLFAMPYDWRYS---NADNAKF---LKQKIDEALKeSGASQVQLVAHSMGGLLVRETLLSnVSYQ- 399 Bacillus lichen...
Q21515       138 IVDSMVSWGYRRGKnVIGAPFDWRKS---PNELNDYLIQLKSLIETTYRwNDNQKIVLVGHSMGNPLSLYFLNNyVDQA- 213 Caenorhabditis ...
P53760       146 LVQNLVNNGYVRDQtVRAAPYDWRVG---PQEQPEYFQNLKALIEEMHD-EYQQRVFLIGHSMGNLNVLYFLLQ-QKQA- 219 chicken
XP_009429354 148 LVQNLVNNGYVRDEtVRAAPYDWRLE---PGQQEEYYRKLAGLVEEMHA-AYGKPVFLIGHSLGCLHLLYFLLR-QPQA- 221 chimpanzee
O94680       234 VIENLAAIGYEPNN-MLSASYDWRLSyanLEERDKYFSKLKMFIEYSNI-VHKKKVVLISHSMGSQVTYYFFKWvEAEGy 311 Schizosaccharom...
4X96_A       178 --------WKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGI--PIMSSIKLKEEQRITTTS------------PWMFP- 234
P40345       343 lygnggrgWVNEHIDSFINAAGTLLGAPKAVPALISGEMKDT--IQLNTLAMYGLEKFFSRIervkmlqtwggiPSMLPk 420 Saccharomyces c...
Q4VCM1       214 pkh--ylkWLDQHIHAYFAVGAPLLGSVEAIKSTLSGVTFGL--PV-SEGTARLLSNSFASS------------LWLMPf 276 thale cress
Q59208       400 -----------PKVKRIIYMGTPFLGSPRAYQAIKYGYNFGI--PFLHEETGKVISAYAPAV------------YELLPs 454 Bacillus lichen...
Q21515       214 --------WKDKYISSFVSLAAPWAGSMQIVRLFASGYNMNYyrVILPPSSLRAMQRSFSSS------------AFLFP- 272 Caenorhabditis ...
P53760       220 --------WKDQYIGGFISLGAPWGGSVKPLRVLASGDNQGI--PLMSNIKLREEQRMTTTS------------PWMFP- 276 chicken
XP_009429354 222 --------WKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGI--PIMSSIKLKEEQRITTTS------------PWMFP- 278 chimpanzee
O94680       312 gng--gptWVNDHIEAFINISGSLIGAPKTVAALLSGEMKDT--AQLNQFSVYGLEKFFSRSerammvrtmggvSSMLPk 387 Schizosaccharom...
4X96_A       235 -----------SRMA------------------------WP-EDHvFISTpsfnyTGRDFQRF-------FAD------- 264
P40345       421 gee-----viwGDMK------------------------SS-SEDaLNNNt---dTYGNFIRFerntsdaFNKnltmkd- 466 Saccharomyces c...
Q4VCM1       277 sknckgdntfwTHFSggaakkdkrvyhcdeeeyqskysgWP-TNIiNIEIpstsvTETALVNM-------TSMecglpt- 347 thale cress
Q59208       455 rkyfdtvaflkKDVV------------------------HPySYEeFLQDreirlDYDPLVKNagqlhekWDNktinvpq 510 Bacillus lichen...
Q21515       273 -----------SPVA------------------------WK-PHEiLATTadknyTVGNIKEF-------FQD------- 302 Caenorhabditis ...
P53760       277 -----------TSLA------------------------WP-EDHvFISTpsynyTYRDYQRF-------FTD------- 306 chicken
XP_009429354 279 -----------SRMA------------------------WP-EDHvFISTpsfnyTGRDFQRF-------FAD------- 308 chimpanzee
O94680       388 ggd-----vvwGNAS------------------------WA-PDD-LNQTn---fSNGAIIRYred-idkDHDefdidd- 431 Schizosaccharom...
4X96_A       265 -------LHFEEGWYMWLQSRDL---------LAGLP--------------------------APGVEVYCLYGVGL--- 299
P40345       467 --ainmtLSISPEWLQRRVHEQY---------SFGYSkneeelrknelhhkhwsnpmevplpeAPHMKIYCIYGVNN--- 532 Saccharomyces c...
Q4VCM1       348 --llsftARELADGTLFKAIEDY---------DPDSKrmlhqlkklyhd--dpvfnpltpwerPPIKNVFCIYGAHL--- 411 thale cress
Q59208       511 ysivghgQTTLLGYVMNPVSRQLvpyfdpgvgDGTVPylsanyaqkdikkqyyvkeehaklpvNP----YVIQQVGHlll 586 Bacillus lichen...
Q21515       303 -------INYMVGWEQYKQAARL---------NGNLS--------------------------SPGVPVHCIYGTGV--- 337 Caenorhabditis ...
P53760       307 -------VNLEDGWYMWEDMKDL---------LKGLP--------------------------PPGVDTYCLYGTGY--- 341 chicken
XP_009429354 309 -------LHFEEGWYMWLQSRDL---------LAGLP--------------------------APGVEVYCLYGVGL--- 343 chimpanzee
O94680       432 --alqflKNVTDDDFKVMLAKNY---------SHGLAwtekevlknnempskwinpletslpyAPDMKIYCVHGVGK--- 497 Schizosaccharom...
4X96_A       300 ---PTPRTYIYDHG------------FPYTDPVGVLYED------------GDDT-VATRSTEL-CGL-WQG------RQ 343
P40345       533 ---PTERAYVYKEEddssa---lnltIDYESKQPVFLTE------------GDGT-VPLVAHSM-CHK-WAQgaspynPA 591 Saccharomyces c...
Q4VCM1       412 ---KTEVGYYFAPSgkpypdnwiitdIIYETEGSLVSRSgtvvdgnagpitGDET-VPYHSLSW-CKN-WL-------GP 478 thale cress
Q59208       587 gieDVQNGMRRTPQktssylyyilsrEDGEFPEVIVSKS------------GRSMrITPEKKEV-----WDDlr--veYH 647 Bacillus lichen...
Q21515       338 ---PTPEKFSWAPG------------YFPDYPPTEFMGD------------GDGT-VNKKSATV-CTN-WIGn-----NN 382 Caenorhabditis ...
P53760       342 ---PTVETYIYDEH------------FPYEDPVDMIYGD------------GDDT-VNKRSSEL-CKR-WRn------QQ 385 chicken
XP_009429354 344 ---PTPRTYIYDHG------------FPYTDPVGVLYED------------GDDT-VATRSTEL-CGL-WQg------RQ 387 chimpanzee
O94680       498 ---PTERGYYYTNNpegqpvidssvnDGTKVENGIVMDD------------GDGT-LPILALGLvCNKvWQTkr--fnPA 559 Schizosaccharom...
4X96_A       344 PQPVHLLPL-------------HGIQHLNMVFSN 364
P40345       592 GINVTIVEMkhqpdrfdirggaKSAEHVDILGSA 625 Saccharomyces cerevisiae S288C
Q4VCM1       479 KVNITMAPQpe---------hdGSDVHVELNVDH 503 thale cress
Q59208       648 GNIVVVHVLdgekplfqelsrsRSSSPAKLLIQR 681 Bacillus licheniformis
Q21515       383 GYKVTVHEV-------------FQADHMAILKHP 403 Caenorhabditis elegans
P53760       386 KQKVHVQEL-------------RGIDHLNMVFSN 406 chicken
XP_009429354 388 PQPVHLLPL-------------HGIQHLNMVFSN 408 chimpanzee
O94680       560 NTSITNYEIkhepaafdlrggpRSAEHVDILGHS 593 Schizosaccharomyces pombe 972h-
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