5SYN


Conserved Protein Domain Family
Abhydrolase_2

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pfam02230: Abhydrolase_2 
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Phospholipase/Carboxylesterase
This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.
Statistics
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PSSM-Id: 396693
Aligned: 10 rows
Threshold Bit Score: 233.808
Threshold Setting Gi: 7404507
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5SYN_C  11 LTDAATVSGAERETAAVIFLHGLGDTG-----HSWADALS-TIRLPHVKYICPHAPR-IPVTLNMKMVMPSWFDLMGLSP 83  human
Q21224   6 NGNPSIVSPRGEHKGTLIFLHGLGDQG-----HGWADAFKtEAKHDNIKFICPHSSE-RPVTLNMGMRMPAWFDLFGLDP 79  Caenorhabditis elegans
O18501  18 LP-AAVVASRSKHSATLIFLHGLGDTG-----HGWSDALK-EYVPDYFKIICPHANS-IPVTLNGGMCMPAWYDIYALSE 89  Schistosoma mansoni
O77821  11 P---AVVPAARKATAAVIFLHGLGDTG-----HGWAEAFA-GIKSPHIKYICPHAPV-MPVTLNMNMAMPSWFDIVGLSP 80  rabbit
Q12354   1 MNGLRVAAKIQPARQTIIFLHGLGDTGsgwgfLAQYLQQRdPAAFQHTNFVFPNAPE-LHVTANGGALMPAWFDILEWDP 79  Saccharomyces cerevis...
O42881   6 N--SVIINPSVAHTATVIFLHGLGDSG-----QGWSFMANtWSNFKHIKWIFPNAPS-IPVTVNNGMKMPAWYDIYSFAD 77  Schizosaccharomyces p...
O14304  11 NACAEIIEGKDKVHNVVILMHGLGDSH-----KSFANMAK-NVPLPNTSYISLRGPYrLPLDFENPGGNWMWGEDVHFDQ 84  Schizosaccharomyces p...
O84138  11 AGIEFIECPGDPEAPVIIFCHGYGASAd----HLTFFPTMcVCANLRPTWVFPHGIE-QLPYQLGGGR--AWFPLDTVLF 83  Chlamydia trachomatis
O05958   5 LEYPEVESKELPPQKLVVLLHGVGSDGh----DLIGLVPYiKNDLPNCHFISPHGIE-DYDMMPYGR---QWFSLRDRSP 76  Rickettsia prowazekii...
P76561   3 HDHFVVQSPDKPAQQLLLLFHGVGDNP-----VAMGEIGNwFAPLFPDALVVSVGGA-EPSGNPAGR---QWFSVQGITE 73  Escherichia coli K-12
5SYN_C  84 DA--PEDEAGIKKAAENIKALIEHEMKNG------------IPANRIVLGGFSQGGALSLYTALTCPH--PLAGIVALSC 147 human
Q21224  80 NA--QEDEQGINRATQYVHQLIDAEVAAG------------IPASRIAVGGFSMGGALAIYAGLTYPQ--KLGGIVGLSS 143 Caenorhabditis elegans
O18501  90 NA--KQDEAGIKEASLELGKFVDAEIKAG------------VPIGNIVIGGFSQGGSVALYNALTSTL--QYGGVVAFSC 153 Schistosoma mansoni
O77821  81 DS--QEDESGIKQAAETVKALIDQEVKNG------------IPSNRIILGGFSQGGALSLYTALTTQQ--KLAGVTALSC 144 rabbit
Q12354  80 SFs-KVDSDGFMNSLNSIEKTVKQEIDKG------------IKPEQIIIGGFSQGAALALATSVTLPW--KIGGIVALSG 144 Saccharomyces cerevis...
O42881  78 MK--REDENGILRSAGQLHELIDAELALG------------IPSDRILIGGFSQGCMVSLYAGLTYPK--RLAGIMGHSG 141 Schizosaccharomyces p...
O14304  85 NGe-LQSEADFSKSFTMISNLIGNLLSYG------------ILSSRIFFFGFGQGAMVALYSCYKLSTkyQLGGIFSFGG 151 Schizosaccharomyces p...
O84138  84 EKliSSQE-ITPDTDRLYQQLLDVDFEKPkqalegliheleRDRSEVIIGGFSQGAMMTTHLMLSSRL--PYRGALICSG 160 Chlamydia trachomatis
O05958  77 HI----IAKLIANNISKLEDIIREKQTELn-----------LTNKDTVIIGFSQGTIIGLYLTLIQQK--PLFCTIGFSG 139 Rickettsia prowazekii...
P76561  74 DN----RQARVDAIMPTFIETVRYWQKQSg-----------VGANATALIGFSQGAIMVLESIKAEPG--LASRVIAFNG 136 Escherichia coli K-12
5SYN_C 148 WLPLHRAFPQAANGSAk--DLAILQCHGELDPMVPVRFGALTAEKLRSVVTpaRVQFKTYPGVMHSSCPQEMAAVKEFLE 225 human
Q21224 144 FFLQRTKFPGSFTANN---ATPIFLGHGTDDFLVPLQFGQMSEQYIKKFNP--KVELHTYRGMQHSSCGEEMRDVKTFLS 218 Caenorhabditis elegans
O18501 154 WLPLHTKFMSSPTLLTmpkDVPVFQCHGLEDYTIPFAMGKLTHELLKTFQLs-KCELNCYPQLSHSSCEKEMGDLRTFLS 232 Schistosoma mansoni
O77821 145 WLPLRASFSQGPINSAn-rDISVLQCHGDCDPLVPLMFGSLTVERLKALINpaNVTFKIYEGMMHSSCQQEMMDVKHFID 223 rabbit
Q12354 145 FCSIPGILKQHKNGINv--KTPIFHGHGDMDPVVPIGLGIKAKQFYQDSCEiqNYEFKVYKGMAHSTVPDELEDLASFIK 222 Saccharomyces cerevis...
O42881 142 FLPLASKFPSALSRVAk--EIPILLTYMTEDPIVPSVLSSASAKYLINNLQl-KCLDRPFEGDAHSLSSESFMAMYKFTQ 218 Schizosaccharomyces p...
O14304 152 TLPLSITLPNHPFHVPv--YLFEKRLHCSCSEYEESRLRKTFKPFHLTCWN--RDDKTDMP-SSPREWYTFVQSISKHLY 226 Schizosaccharomyces p...
O84138 161 AAVPNQSWEENASLCG---KTPYIQSHGYDDPILPYFLGERLYKVLTASLK---GEMVSFH-GGHEIPVVMMQKIQESIA 233 Chlamydia trachomatis
O05958 140 ALIPPMKVN---NKLT-----PICLIHGELDQVINVSEMYNASNYLSKLNI--EHSGHKLTSLAHSIDGRGLEIAINFIN 209 Rickettsia prowazekii...
P76561 137 RYASLPETAS--TATT------IHLIHGGEDPVIDLAHAVAAQEALISAGG--DVTLDIVEDLGHAIDNRSMQFALDHLR 206 Escherichia coli K-12
5SYN_C 226 KLL 228 human
Q21224 219 AHI 221 Caenorhabditis elegans
O18501 233 KNI 235 Schistosoma mansoni
O77821 224 KLL 226 rabbit
Q12354 223 KSL 225 Saccharomyces cerevisiae S288C
O42881 219 TVI 221 Schizosaccharomyces pombe 972h-
O14304 227 IHN 229 Schizosaccharomyces pombe 972h-
O84138 234 LWS 236 Chlamydia trachomatis
O05958 210 TCH 212 Rickettsia prowazekii str. Madrid E
P76561 207 YTI 209 Escherichia coli K-12
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