1NEP,2AG9,6R4M


Conserved Protein Domain Family
E1_DerP2_DerF2

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pfam02221: E1_DerP2_DerF2 
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ML domain
ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.
Statistics
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PSSM-Id: 396688
Aligned: 86 rows
Threshold Bit Score: 60.0388
Threshold Setting Gi: 75170184
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1NEP_A                   2 PVKFKDCg--SwvGViKEVNVSpcptQPcKLHRGQSY-SVNVTFTSNTQSQSSKAVVHGIVmGIPVPFPIPES--DGCK- 75  cattle
Q16UX8                  20 QLEVQKCkngA---VpNKLEIEgctkAPcQIVNGQNL-RFKAEFTNPKATKTLTAKVIARVaGLIIPYELPEEhrDGCKk 95  yello...
Q1DH44                  17 GIDVHSCg-dEy-PHpTQVIVPgcnvMPcEVPNLSDF-SFSVRFAPSFPTGTLAVDVSATLgDFNLPYETPDHlrDGCAn 93  yello...
WGS:AAAB:AGAP001956-PA  18 QTPFRPCs-gGr-PTpASLNIEgctaLPcTITSGAPLvARGIGIVSPVATPTLTAHLTARLlGLDVGFDIPEElrDACAv 95  Anoph...
Q17KJ6                  18 DVNFRACp-dGs-PTpTSLAVNncteSScILSADQPLyALASGIVSTVESNTATAYIVVRLdDVEVDYQVPEEhvDACRe 95  yello...
Q16I08                  18 AVNFRACp-nGa-PTpASLTVNncsgDEcILVAGQALnARANGIVSPVGSASATAHIVARVaGLDVGFELPPEltNACQa 95  yello...
Q17KJ7                  18 AVNFRVCs-nKa-PTpTTLTVNdcsgDNcVLVAKKPLyALASGIVSSVNSKTATTRIVARFlGMDLGFRTPPEltNACNg 95  yello...
Q17KJ8                  18 NVNFRACp-nRa-STpTSLKVNdcygDNcVLVARKPLrAQAIGIVSRYNSNTATIKIIARFlGKDAGYRVRPEltNACKg 95  yello...
Q1DH41                  18 LTPVRQCp-nGa-GLpQSVDINgctgSPcPIVNGQPLlAHAVGITSPVATNGLEAYIIIRLaGLQIPFPMPDGleDACAn 95  yello...
Q171N3                  17 QTPVRQCp-nGa-GLpQSVDINgcttSPcPIQNGAPIqAVARGITSPVATNGMSSYIVIRLaGLQIPFPMPDGleDACAv 94  yello...
1NEP_A                  76 --SGiRCPIEKDKTyNyVNKLPVK-NEYPSIkVVVEWELTDDKNQRFFCWQIPIEV 128 cattle
Q16UX8                  96 -lTNaKCPLADNQRvEaAGDVPVE-SPIANVkANIEFQLHGDSGISL-CFKIDAKI 148 yellow fever mosquito
Q1DH44                  94 idGS--CPLAAGQEvTlSGTAPVE-APLTRVtVRLRFEVTGDGGQKAVCFAADVRL 146 yellow fever mosquito
WGS:AAAB:AGAP001956-PA  96 giTGaSCPIAAGQSfDyELNYAME-LPLVGItVQVEVGLTAADGSAVTCVEIDAAI 150 Anopheles gambiae str. PEST
Q17KJ6                  96 giVGg-CPVIPGIPfNyAVANDNLtIPSGGFqVEIEFGLEGDGGVKIGCVRFDAYI 150 yellow fever mosquito
Q16I08                  96 glVAg-CPIVAGTAfDyVLIDDSLdAPARDIpVEIEVGLTGDNGIALACVRFDARI 150 yellow fever mosquito
Q17KJ7                  96 giLGg-CPIVAGRAfNyVLVDDSLeVPAVNMpVEIEVSLTGDGGVALGCVRFNARI 150 yellow fever mosquito
Q17KJ8                  96 -vVGg-CPIIAGRTyNfVFVDEVLeVPAVNIpVEIEVSVSGDGGVVLGCVRFDAWI 149 yellow fever mosquito
Q1DH41                  96 gtPAgTCPVSAGQTfDyNLDFEGQvLQLSGVtVQVEVGLRADDGSDVTCVAFDAAI 151 yellow fever mosquito
Q171N3                  95 gtAPgTCPVSAGQTfDyTLDHEGQaLALTGVtVQVEVGLRADDNSVIGCLLFDATI 150 yellow fever mosquito
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