Conserved Protein Domain Family

cl12018: Peptidase_M48 Superfamily 
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Peptidase family M48
Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologs such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit.
Accession: cl12018
PSSM Id: 353340
Name: Peptidase_M48
Created: 20-Jan-2010
Updated: 19-Sep-2018
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