1WY8


Conserved Protein Domain Family
Ubl_UHRF2

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cd17123: Ubl_UHRF2 
ubiquitin-like (Ubl) domain found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
UHRF2, also termed Np95/ICBP90-like RING finger protein (NIRF), or Np95-likeRING finger protein, or nuclear protein 97, or nuclear zinc finger protein Np97, or RING finger protein 107, or E3 ubiquitin-protein ligase UHRF2, was originally identified as a ubiquitin ligase acting as a small ubiquitin-like modifier (SUMO) E3 ligase that enhances zinc finger protein 131(ZNF131) SUMOylation but does not enhance ZNF131 ubiquitination. It also ubiquitinates PCNP, a PEST-containing nuclear protein. Moreover, UHRF2 functions as a nuclear protein involved in cell-cycle regulation and has been implicated in tumorigenesis. It interacts with cyclins, CDKs, p53, pRB, PCNA, HDAC1, DNMTs, G9a, methylated histone H3 lysine 9, and methylated DNA. It interacts with the cyclin E-CDK2 complex, ubiquitinates cyclins D1 and E1, induces G1 arrest, and is involved in the G1/S transition regulation. Furthermore, UHRF2 is a direct transcriptional target of the transcription factor E2F-1 in the induction of apoptosis. It recruits HDAC1 and binds to methyl-CpG. UHRF2 also participates in the maturation of Hepatitis B virus (HBV) through interacting with HBV core protein and promoting its degradation. UHRF2 contains an N-terminal ubiquitin-like domain (Ubl), a tandem Tudor domain (TTD), a plant homeodomain (PHD) finger, a set- and ring-associated (SRA) domain, and a C-terminal RING finger.
Statistics
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PSSM-Id: 340643
View PSSM: cd17123
Aligned: 7 rows
Threshold Bit Score: 147.324
Threshold Setting Gi: 159163482
Created: 15-Nov-2016
Updated: 9-Jun-2017
Structure
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Program:
Drawing:
Aligned Rows:
 
key conservedkey conserved
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have other functions, for example for NEDD8 it is involved in the mechanism of protein neddylation

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #                                             
1WY8_A         8 MWIQVRTIDGsKTCTIEDVSRkaTIEELRERVWALFdvrPECQRLFYRGKQLENGYTLFDYdVGLNDIIQLLVR 81  human
XP_004949134   1 MWIQVRTIDGtETQTIDDLSRltKIECLREKIQETFrvsPDRQRLFYRGKQLEDGHTLFDYnVGLNDIVQLLIR 74  chicken
NP_001096244   1 MWIQVRTIDGtETQTIDDLSRltKIESLRLKIQESFnvtPDRQRLFYRGKQLEDGHTLFDYnVGLNDIVQLLIR 74  western clawed frog
XP_017208475   1 MWIQIRTIDGkETRTVEDLSRltKIESLRVKIRDIFnvkPEQQRLFYRGKQMEDGQTLFDYnVGLNDIVQLLIR 74  zebrafish
XP_014348024   1 MWIQVRTIDGkETQTIDDLSRltKIECLRLKIQESFnvsPEKQRLFYRGKQLEDGHTLFDYnVGLNDIVQLLIR 74  coelacanth
Q96PU4         1 MWIQVRTIDGsKTCTIEDVSRkaTIEELRERVWALFdvrPECQRLFYRGKQLENGYTLFDYdVGLNDIIQLLVR 74  human
AAI28674       1 MWIQVRTIDGtETHTIDDLSRltKIESLRLKIQETFnvtPDRQRLFYRGKQLEDGHTLFDYnVGLNDIVQLLIR 74  African clawed frog

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