1TTN


Conserved Protein Domain Family
Ubl_UBTD2

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cd17121: Ubl_UBTD2 
ubiquitin-like (Ubl) domain found in ubiquitin domain-containing protein 2 (UBTD2)
UBTD2, also termed dendritic cell-derived ubiquitin-like protein (DC-UbP), or ubiquitin-like protein SB72, is a potential ubiquitin shuttle protein firstly identified in dendritic cells and implicated in apoptosis. It binds proteins involved in the ubiquitination pathway and may play an important role in regulating protein ubiquitination and delivery of ubiquitinated substrates in eukaryotic cells. UBTD2 is expressed in tumor cells but not in normal human adult tissue suggesting a role in tumorogenesis. It can potentially regulate the stability of proteins involved in various physiological processes relevant to many disease phenotypes, such as ageing and cancer. UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.
Statistics
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PSSM-Id: 340641
View PSSM: cd17121
Aligned: 6 rows
Threshold Bit Score: 146.659
Threshold Setting Gi: 82182989
Created: 9-Jul-2015
Updated: 9-Jun-2017
Structure
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Program:
Drawing:
Aligned Rows:
 
key conservedkey conserved
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have other functions, for example for NEDD8 it is involved in the mechanism of protein neddylation

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                                               
1TTN_A        23 ECQLRLRLSTGKDLKLVVRstDTVFHMKRRLHAAEGVEPGSQRWFFSGRPLTDKMKFEELKIPKDYVVQVIVSQP 97  human
NP_001087919 151 ECQLRLRLSTGKDLRLMVRsaDTVYHMKRRLHAAEGVEPASQRWFFSGRPLTDKMRLEELKIPKDFVVQVIVSQP 225 African clawed frog
EOB08344     128 ECQLRLRLSTGKDLKLMVRsmDTVYHMKRRLHAVEGVEPGSQRWFFSGRPLADKMKLEELKIPKDYVVQVIVSQP 202 mallard
XP_005992558 151 ECQLRLRLSTGKDLKLTVRstDTVYHMKRRLHTVEGVEPGSQRWFFSGRPLTDKMKLEELKIPKDYVVQVIVSQP 225 coelacanth
XP_007899453 151 ECQLRLRLSTGKDLKLAVRstDTVYHMKRRLHTAEGVEPFSQRWFFSGRPLTDKMKLEELKIPKDYVVQVIISQP 225 elephant shark
Q6DG43       151 ECQLRLRLSTGRDLRLAVRtsDSVQQMKRRLQTQEGVAATSQRWFFSGRPLTDKMKLEELKISRDYVVQVIVSQP 225 zebrafish

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