Conserved Protein Domain Family
Ubl_UBTD1

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cd17120: Ubl_UBTD1 
ubiquitin-like (Ubl) domain found in ubiquitin domain-containing protein 1 (UBTD1)
UBTD1 is the mammalian homolog of the mitochondrial Dc-UbP/UBTD2 protein, both of which contain an N-terminal ubiquitin binding domain (UBD) and a C-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. As a tumor suppressor, UBTD1 plays a pivotal role in in regulating cellular senescence that mediates p53 function. It is also involved in MDM2 ubiquitination and degradation.
Statistics
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PSSM-Id: 340640
View PSSM: cd17120
Aligned: 6 rows
Threshold Bit Score: 140.454
Threshold Setting Gi: 71834666
Created: 9-Jul-2015
Updated: 9-Jun-2017
Structure
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Aligned Rows:
 
key conservedkey conserved
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have other functions, for example for NEDD8 it is involved in the mechanism of protein neddylation

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #                                            
Q9HAC8       151 LKVRLSTGKDVRLSAslpDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLqetKIQKDFVIQVII 219 human
NP_001025436 152 LKVRLSTGKDLRLNAsmsDTIGLLKKQLQAQEDIDISHQRWFFSGKLLTDKTRLqdtKIQKDFVIQVIV 220 zebrafish
XP_005995884  58 LKVRLSTGKDVRLNVsmaDTIGQLKKQLHAEEGIVPNWQRWFFSGKLLTDKTKLqetKIQKDFVIQVIV 126 coelacanth
XP_007903901 188 LKVRLSTGKDVKLSAsmsDSIGQLKRQLHAEEEIEPARQRWFFSGRLLTDKIRLqetKIQKDFVVQVIV 256 elephant shark
EMP27911      60 LKVRLSTGKDLRLSAsvaDTVGQLKKQLQAQEGIEPGWQRWFFSGKLLTDRTRLheaKIQKDFVIQVIV 128 green sea turtle
XP_012821813 155 LKVRLSTGKDVKLNAsmvDTIGQLKKQLHAVEGIEPCWQRWFFSGKLLTDRMKLqetKIQKDYVIQVIV 223 western clawed frog

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