Conserved Protein Domain Family
Ubl2_FAT10

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cd17053: Ubl2_FAT10 
ubiquitin-like (Ubl) domain 2 found in leukocyte antigen F (HLA-F) adjacent transcript 10 (FAT10) and similar proteins
FAT10, also termed ubiquitin D (UBD), or diubiquitin, is a cytokine-inducible ubiquitin-like (Ubl) modifer that is highly expressed in the thymus, and targets substrates covalently for 26S proteasomal degradation. It is also associated with cancer development, antigen processing and antimicrobial defense, chromosomal stability and cell cycle regulation. FAT10 is presented on immune cells and under the inflammatory conditions, is synergistically induced by interferon gamma (IFNgamma) and tumor necrosis factor (TNFalpha) in the non-immune (liver parenchymal) cells. FAT10 contains two Ubl domains. The family corresponds to the second Ubl domain of FAT10. Some family members contain only one Ubl domain.
Statistics
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PSSM-Id: 340573
View PSSM: cd17053
Aligned: 9 rows
Threshold Bit Score: 86.6319
Threshold Setting Gi: 557024847
Created: 12-Dec-2016
Updated: 9-Jun-2017
Structure
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Aligned Rows:
 
key conserved
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering), the other 6 lysines are not conserved in this family; may have other functions, for example in NEDD8 K27 is involved in the mechanism of protein neddylation

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #                                               
O15205        90 LFLVESgd--eaKRHLLQVr-rSSSVAQVKAMIETktGIIPETQIVTC-NGKRLEdg---kmMADYGIRKGNLLFLA 159 human
XP_004694779  90 LTVMEPge--ggLKHHIQVs-rSNSGAQVKGKIESntAVNLNEKFVIY-KGKRIEdg---ktMGEHGIKGGDTLYVI 159 star-nosed mole
XP_003057431 367 ETVTTAp----gDTYTLFIh-nSKTVAQLKARVKDldGVPPERQILFF-NGTRLEkdg--kaLREYDIETGDTVTVH 435 Micromonas pusilla...
XP_006012591  88 MTVISYnd---nRHYPIRAkkrSTPVNKVMKMLEAqsGVPPAKQILTL-NGKRVEpg---kkLGEYRVKTGSLIHMV 157 coelacanth
EME43875     120 FTVNVSdlhgiaTTFCVSVf-gSTTIAELADMVHDqsGIPPDEQRLVW-KNYRLNqph--atLSSYGIASGEDLYLL 192 Dothistroma septos...
KQK90128     294 LTIDSK------TVIVLEVe-rSDTISSVMAQLEDklGVPPVMQWISC-NERSLRcdd-agtLADHGVQKESTLFVF 361 foxtail millet
ABK63480       1 MDINIKml--ngTVHTLTVy-pDDTVGKLKNLIHSqfGEPPHKQKLVFvNGQRIDlsddsrtVGSYGLKSGSTVSLL 74  northern snakehead
ETE60426      46 LTLSVKll--tgEVHSVVCs-pNQTVWDFKTQLGHqtGVSPYQQKLASsNGAHLDlqd-vtpLSNYGLRTGDTLLLM 118 king cobra
EDV29059      18 SQIYISlp--trEVITLYNvpnQVTILHLKSMIELysGIPPNVQILQYlTTTDLQdy---rtLVSYGIKTRDQLTLT 89  Trichoplax adhaerens

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