4KIK,3QA8,3RZF,4E3C,4KIK,5EBZ


Conserved Protein Domain Family
Ubl_IKKA_like

?
cd17046: Ubl_IKKA_like 
ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
IKK, also termed IkappaB kinase, is an enzyme complex involved in propagating the cellular response to inflammation. It is part of the upstream nuclear factor kappa-B kinase (NF-kappaB) signal transduction cascade, and plays an important role in regulating the NF-kappaB transcription factor. IKK is composed of three subunits, IKK-alpha/CHUK, IKK-beta/IKBKB, and IKK-gamma/NEMO. The IKK-alpha and IKK-beta subunits together are catalytically active whereas the IKK-gamma subunit serves a regulatory function. IKK-alpha and IKK-beta phosphorylate the IkappaB proteins, marking them for degradation via ubiquitination and allowing NF-kappaB transcription factors to go into the nucleus. IKK-alpha, also known as IKK-A, or IkappaB kinase A (IkBKA), or conserved helix-loop-helix ubiquitous kinase (CHUK), or I-kappa-B kinase 1 (IKK1), or nuclear factor NF-kappa-B inhibitor kinase alpha (NFKBIKA), or transcription factor 16 (TCF-16), belongs to the serine/threonine protein kinase family. In addition to NF-kappaB response, it has many additional cellular targets in an NF-kappaB-independent manner. For instance, it plays a role in epidermal differentiation, as well as in the regulation of the cell cycle protein cyclin D1. IKK-beta, also known as IKK-B, or IkappaB kinase B (IkBKB), or I-kappa-B kinase 2 (IKK2), or nuclear factor NF-kappa-B inhibitor kinase beta (NFKBIKB), belongs to the serine/threonine protein kinase family as well. It interacts with many different protein partners and has been implicated in the treatment of many inflammatory diseases and cancers. Both IKK-alpha and IKK-beta contain an N-terminal catalytic domain followed by a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions.
Statistics
?
PSSM-Id: 340566
View PSSM: cd17046
Aligned: 24 rows
Threshold Bit Score: 86.5409
Threshold Setting Gi: 1009412896
Created: 9-Jul-2015
Updated: 9-Jun-2017
Structure
?
Program:
Drawing:
Aligned Rows:
 
key conserved
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering), and it is poorly conserved in this family, the other 6 lysines are not conserved in this family, for most the residue corresponding to K63 is a conserved Glu/Asp; may have other functions, for example in NEDD8 K27 is involved in the mechanism of protein neddylation

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                                                    
4KIK_B       316 KLVHILNMvtGTIHTYPVTEDESLQSLKARIQQDtGIPEEDQELLQEaGLALIpDKPATQCisdgklneghTLDMDLVFL 395 human
AAX56336     307 KIVNILNVstNQLLSYPLMEQLSMQDLQRTIEQEtKIKVADQDILFAsGAPPEpNQGASQCwn------vpGEEDWVVFL 380 Pinctada fucata
Q4G3H4       312 KVVHILNMttTQVHSFLLSPDEGLHSLQQRIENEtKIELLNQDLLQEtGVMSDpRKPAAQCvld----gvrGWDSYIVYL 387 zebrafish
EEN60740     318 KIVHVLDMhtGQLYSYPVEEDETVESLMIRLALEtQMPVEHQELMFStGMSPDpNGKVSQCwe------epGKDDNFVFL 391 Florida lancelet
XP_007896804 313 KYVHILNMtsARIHSFLIKPDESLLSLQMHIETEtGIAAANQELLLEtGISLDpRKPASQCvld----gvrGWDSYMVYL 388 elephant shark
KFM67863      28 KVVLVFCVdtFRMLSFEIDKTLSLEDFEKMLEVEsGIPVTSQEILLPkGHVPNpDVGAHQFis------nlEEEEFIVFL 101 Stegodyphus mim...
XP_012262041 312 KVVHVFCVseYRIISYEVNESTTLGNLQSRLEEDtKIAVFNQELIRStGEVITeNEVLHDTflt-----lfSKEGILIHL 386 coleseed sawfly
XP_005096610 311 KLLHILHVeaNTVLSYTVDETKTIAMVQAAIEERtGVPREAQDIILAnGVKLNpGDLAVQGcc------esNVDDLILFL 384 California sea ...
XP_013406195  90 KVIHFLCVttNQLLSYPVTENHKLLDVMNVIEQEtRIPVAEQEILFAsGIVPDiNQPAVQCwd------eqGEDESIVFL 163 Lingula anatina
XP_006003566 231 KIVNILNMtsAKILSLPVGPDESLNSLQQRIEREtGIATCNQELLLEtGMSPDpRKPACQCvld----evrGWDKYIVYL 306 coelacanth
Feature 1         
4KIK_B       396 F 396 human
AAX56336     381 F 381 Pinctada fucata
Q4G3H4       388 F 388 zebrafish
EEN60740     392 F 392 Florida lancelet
XP_007896804 389 F 389 elephant shark
KFM67863     102 F 102 Stegodyphus mimosarum
XP_012262041 387 P 387 coleseed sawfly
XP_005096610 385 F 385 California sea hare
XP_013406195 164 F 164 Lingula anatina
XP_006003566 307 F 307 coelacanth

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap