2HYE


Conserved Protein Domain Family
Cullin

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pfam00888: Cullin 
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Cullin family
Statistics
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PSSM-Id: 334305
View PSSM: pfam00888
Aligned: 401 rows
Threshold Bit Score: 148.482
Threshold Setting Gi: 124465559
Created: 18-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HYE_C        66 LHEAVRAVqs--sTSIRYN-------LE-ELY------QAVENLCs--HKVSPMLYKQLRQACEDHVQAQIlpfre---- 123 human
Q24DT3        32 yfeknwleieqflKSIYESedincycFQ-HFY------DMISSICd--NEFDELLYKKLEEFYRLKFNVILndi------ 96  Tetrahymena the...
A0BYN1        21 LDDACYLIae--hQTKQLS-------FA-ELY------QHAYKLIl--NKFGDFAYSQLQISIHNVVDKLIspln----- 77  Paramecium tetr...
Q236H3        58 IEQAIQMIye--kKTHTLS-------YQ-ELY------HHAYILAf--YGHGDQAYSRLKSLLEKYSLKMLntlg----- 114 Tetrahymena the...
A0CFE8        18 LRDHIEKVlkgekKVYNTK-------ETmTFY------TEIFNYIvqgEQQGQKMYDLFKGYNEDFLKESEkiarq---- 80  Paramecium tetr...
XP_001014520  82 VRRNLKTGea--iKISNEE-------YC-KLQseirntD-QFNLIg----------NWHKEQILNYVNS----------- 129 Tetrahymena the...
XP_001306671  17 VEEGLDSIih--rQPCKHD-------FN-SLY------SSTDKIIn--NDNQAKLFDLLNNKINEEIAKWEkqlk----- 73  Trichomonas vag...
XP_001313897  18 ISKSITSIlt--hKHSSLS-------LS-YLY------NCMNNLVn--NSCTNKLRDTLQNHLDKQFSKQYnsls----- 74  Trichomonas vag...
CCK70086      29 LKEGLDKIyt--dCIEDVS-------YQ-DLY------KLVYSLVi--NENGELLYKHLKEYLVERLTSSMvetlmpeip 90  Kazachstania na...
XP_003958060  35 IDDAFEKIya--nNTEEIS-------FE-KTY------HVVYNLVi--YKRSDDLYNHLKELFTSKLTELKdsqfs---- 92  Kazachstania af...
2HYE_C       124 -----dsldSVLf-L------------KKINTCWQDHCRQMIMIRSIFLFLDR---------------TYVlqnStl--p 168 human
Q24DT3        97 ------alqPEDf-I------------NKIEKEWIKINRCLIILSEIFKQFEG---------------SY---------- 132 Tetrahymena the...
A0BYN1        78 ------isnDDQl-L------------YDFVQAFEEVQHFSKLLAGILLYMEK---------------SYilqk---slk 120 Paramecium tetr...
Q236H3       115 -----yydsEEQi-L------------VKMVAVWQDYKQMINILKGIFLYLDN---------------NYvttk---nlq 158 Tetrahymena the...
A0CFE8        81 -----slksDKNf-I------------EEILYQHEIYEIHTRILQSYFTYLDRsfvev-----lnntsQY---------- 127 Paramecium tetr...
XP_001014520 130 ----------IKidLdsktnvpeeeyiKLISKHYYDFQILVMWIQKFLMSHET---------------FYF---Kaqlqt 181 Tetrahymena the...
XP_001306671  74 ------evtSNSl-L------------SLFSTLYDNFKIYSDIIPKIYSSYDSksspenksrmiirriYF---------- 124 Trichomonas vag...
XP_001313897  75 -----ktalVNPl-V------------IKFSKHCSYFASFLKILPKLYSRYDEsla---------ensEY---------- 117 Trichomonas vag...
CCK70086      91 pnqeegleqTWTf-L------------IKFDQFFEREAKRFKLVADVMIYFDK---------------VYC---Naqrip 139 Kazachstania na...
XP_003958060  93 -----dlnqDWEi-L------------QKVAEFWKIQRENFNLVADLMIYLDR---------------VYC---Ksnrlp 136 Kazachstania af...
2HYE_C       169 SIWDM-----GLELFRTHIIs------dKMvqSK---TIDGILLLIERERSG-Ea----vD----Rs-LLRSLLGML--- 221 human
Q24DT3       133 -LYKT-----KTPSFDNFILkilsdqfnQEfnSLldaIITSLLDTFRNIR----------DqnpyNheQLKHLMGMI--- 193 Tetrahymena the...
A0BYN1       121 TIKTI-----CNESFKIKCFek-----dQNlaNK---LLNCFLSQIRNDR----------NsqfiEhfKLKKALQIL--- 174 Paramecium tetr...
Q236H3       159 PVLVL-----GYEVFQQILFiq-----kSEiySK---VLEIILTMIDKQRLGen----------iEgqLIQKIIQMS--- 212 Tetrahymena the...
A0CFE8       128 PNLKQqakkqFYEQFYNKLFf---------------sIKEEFKAKLKLDRi-----------------LLDKESQLLlqr 175 Paramecium tetr...
XP_001014520 182 -----tcfkkSFEFFRDEYF--------LGlkDR---LIEKVFKFVQKAR----------QnvdvPkeELKRVVQIY--- 232 Tetrahymena the...
XP_001306671 125 ----------KLVISDRSIIs---------------sVTKALLKQIDYFRd---------TptdtNysIPKNIVDSF--- 167 Trichomonas vag...
XP_001313897 118 RTEKI-----LFTKFKEKVLn------qTKvvDL---IIKSMIDVIEDARt---------NrivsGtaNLRQIIELF--- 171 Trichomonas vag...
CCK70086     140 EVFDL-----GLNAFRDTVV--------FPlkDN---LNESIIKVINNARDEgQikrsfvLeavqIs-VLKSLFHMM--- 199 Kazachstania na...
XP_003958060 137 EIVDL-----ALHVFRDIIL--------HPlkED---VNKAISVTINQVRQT-Ps----yGns-kFe-VLKELISML--- 190 Kazachstania af...
2HYE_C       222 -S--DL---------------------------QVYK----------DSFELKFLEETNCLYAAEGQRLMQe-ReV-PEY 259 human
Q24DT3       194 -I--KIg---------------------------SYE----------NQFKSHFFEQSNKYYLDLQQKHRA--NfDlRVY 231 Tetrahymena the...
A0BYN1       175 -I--DLnqeqqiknkey------nytidyrindDFYK----------HFLERKLIQDSRSYFKEESQSNLN--KmTiEEY 233 Paramecium tetr...
Q236H3       213 -V--DLgmkaniqkcnqy---srqiqyeyipelTIYE----------KYFEKGYLDCSEKYFSEESQRLIL--QlSpKDY 274 Tetrahymena the...
A0CFE8       176 vY--KI----------------------------IYGmktfqdignnQLIQKEIKEDSKTYYQQQYSNFQQ------QSF 219 Paramecium tetr...
XP_001014520 233 -DdqDFgndirieedrqshklrvisdsssnkqsNNYV----------DLFEKPYLVEIEKHFQK-QASLWT--DkTtPEY 298 Tetrahymena the...
XP_001306671 168 -Y--------------------------------QFNpdcdennkilATFKIDFTGGVYAYFNQ-FFEKRN--EcDiAKY 211 Trichomonas vag...
XP_001313897 172 -Y--------------------------------EYKnsncd-rsifENFMASLKESTKKKYEN---EYNS--SeNfVEF 212 Trichomonas vag...
CCK70086     200 -EtiSAeknd--------------------dpnHFYT----------GIFEPLLIERSSEYYRN----NVDwtDyTaLQT 244 Kazachstania na...
XP_003958060 191 -E--TIsdk----------------------ddTFFE----------TYFEDYFINETKNYYDN----TISaiNlPaPDL 231 Kazachstania af...
2HYE_C       260 LNHVSKRL---EEEGDRVI--------TY-LDHSTQ-------KP-LIACVEKQLLG-EHL---------------TAIL 303 human
Q24DT3       232 LQEIEHRL---QQETGLIE--------AY-LSKATG-------KI-LIDLIQKHLIA-ENL---------------ETIF 275 Tetrahymena the...
A0BYN1       234 ILFVEKRY---LDEVDRVQ--------HY-IPKISH-------QK-VLDCFIKIYIT-SNA------------------- 273 Paramecium tetr...
Q236H3       275 IIAVERRF---LEEKKRVH--------SY-FYQTSK-------NK-IQSLFFQKYIN-DFA---------------KAIV 318 Tetrahymena the...
A0CFE8       220 LDQIKSLVqfkQEELGRIRlifgceqsE--L------------QKeLIDLFNNYIIN-SYA---------------SDLN 269 Paramecium tetr...
XP_001014520 299 VQEALIAL---NKEEQLCQ--------DY--YPRSM-------NP-INQTINGIIIK-DQT---------------QYLL 341 Tetrahymena the...
XP_001306671 212 TSDSFTHL---TLEEN--------------I--IST----------IFRKVEADLMFkESVcalfdygdffdidksINVA 262 Trichomonas vag...
XP_001313897 213 LKRIKELL---DFEEN------------LlL--KAIfkdeedvNE-ILMIAHESAIF-KNTetfanqkdfqvppiySALQ 273 Trichomonas vag...
CCK70086     245 FEKMGAMI---KFEKAFME--------GL-INPDSS-------HK-LIDILTNTFVS-GKL---------------KDIL 288 Kazachstania na...
XP_003958060 232 FAKIKDLI---ASEYSLDL--------NF-LNPDTC-------TK-IKTSIEEFLIS-EKF---------------DVIF 275 Kazachstania af...
2HYE_C       304 QKg---LD---HLLd-------------En-RVPDLAQMYQLFSRV----RgGqq-aLLQHWSEYIK------------- 345 human
Q24DT3       276 SNgf------dDLLnq-----------rD---YQNLQRLFHNMRNIdkldF------LKKNWNQYIR------------- 316 Tetrahymena the...
A0BYN1       274 -----------QHIsqglyd---fieneK---TAIIIIIFQLFVKSeefdL------FVKTFSQIII------------- 317 Paramecium tetr...
Q236H3       319 DNqengLF---NWLdn-----------dE---VVIIKKSHTLFQNTkesyTi-----FLNIFYKYVA------------- 363 Tetrahymena the...
A0CFE8       270 SDnndtLK---NIIiq-----------dY---YEQFGQLVKFFDHFksntHi-----FVRKFQEIII------------- 314 Paramecium tetr...
XP_001014520 342 EHst-gIE---NMLkn-----------gK---DNEMKDLYKLLCRVkeslAq-----LGQKVRTYYQ------------- 385 Tetrahymena the...
XP_001306671 263 PL----LEkdeTDL------------------LDRLNKLTRLYMNGrvepDinrvepLIDLLCNYIKnrmlsfrpqfedg 320 Trichomonas vag...
XP_001313897 274 DK---------NLLrwlirdsylrfhqknhiMCEFIPKICEFMTKDik--------sFEPKFSDHMKlndki-------- 328 Trichomonas vag...
CCK70086     289 GEli------nEVM--------------TskDRTLLQRLSSISED-----EeYrr-dLVEGVKDYIS------------- 329 Kazachstania na...
XP_003958060 276 VPli------eTTL--------------KscNKQLLFEVYSLINE-----TsYrs-rLLEIMDTIVF------------- 316 Kazachstania af...
2HYE_C       346 -----------TFG----TAIVINpek----------------------------------------------------- 357 human
Q24DT3       317 -----------RKG----EEIVNeen------------------------------------------------------ 327 Tetrahymena the...
A0BYN1       318 -----------DDL----QILNQNantl---------------------------------------------------- 330 Paramecium tetr...
Q236H3       364 -----------HQT----SALAARqst----------------------------------------------------- 375 Tetrahymena the...
A0CFE8       315 -----------QQG----QEIIVEqknrisqtki---------------------------------------------- 333 Paramecium tetr...
XP_001014520 386 ------------------SCISQKckdakekisafkpd------------------------------------------ 405 Tetrahymena the...
XP_001306671 321 paksenkeegaKEGgdeeKAAPAKktvakktvakkiikkkvvakkedneekeddeekeneekpttaepkmrivkkatpka 400 Trichomonas vag...
XP_001313897     -------------------------------------------------------------------------------- Trichomonas vag...
CCK70086     330 -----------RDF----YSIKLDevtrkk-------------------------------------------------- 344 Kazachstania na...
XP_003958060 317 -----------NTI----RGIKIEesskkr-------------------------------------------------- 331 Kazachstania af...
2HYE_C       358 ----------------------dkDMVQDLLDFKDKVDHVI--EVCFQ------K-------NER----------FVNL- 389 human
Q24DT3       328 ----------------------qdDITQHLLDFFHDLDIII--QKCFE------N-------TNL----------LKQA- 359 Tetrahymena the...
A0BYN1       331 --------------------qgfiKLYEKIFSLYDKIAQYGnnEHQYK---------------------------FHKA- 362 Paramecium tetr...
Q236H3       376 ---------------------pvkEYIEDIILFRLKIINIM--QEAFF------S--------------------LLKTd 406 Tetrahymena the...
A0CFE8       334 ---------------kqekedqksKFLEQLISLQQSYKKLI----------------------------------YDHAe 364 Paramecium tetr...
XP_001014520 406 ----------ktknirdftketaiEWVKGLIEFKIFVDNQI--STLFS------N-------DLE----------LQKA- 449 Tetrahymena the...
XP_001306671 401 gtasaaeksskskigkdekitamkDLIFTALKLYSNFNKIF--QDSSD--------------KKK----------MSNA- 453 Trichomonas vag...
XP_001313897 329 --------------------tqihEIIKKVLSQTEPFEFVFcsQEHMRkksddpNfdmekeaREK----------FEKA- 377 Trichomonas vag...
CCK70086     345 -------------------aiaaaKWVSDLVEKFEQYSSFL--KGAAFa-----EsipsntaNEGhs------ssIASV- 391 Kazachstania na...
XP_003958060 332 -------------------vqvasEWVSQVIDFYLKYQDLI--DFVQIe-----DnenvdndDAAnesdlpsrlpSSHF- 384 Kazachstania af...
2HYE_C       390 --------MKESFETFI-NkrpnkPAEL-----IAKHVDSKLRa----gNKEaT--DEELERTLDKI-MILFRFIH-GKD 447 human
Q24DT3       360 --------KNYALEHVL-SikvntIAEL-----TSKHIDTKLKkqn-----ktMqdHDQIEKDVDDA-LELFRYLP-AKD 418 Tetrahymena the...
A0BYN1       363 --------IKNAFEQVI-Nkdnf------immeLNIYFDFLMKk--------eTlrDEEKKLQIDKG-FLIFKLVQ-SKD 417 Paramecium tetr...
Q236H3       407 dqltiqrqTQKSFEDSL-Nds-nfPTEQ-----LNCYIDEAFQkd--fkNKS----EQQIEEVLNSV-FEIFCLIR-NKD 471 Tetrahymena the...
A0CFE8       365 nnqfllanLRVAFEMITaN-----AEQH-------FIMESLLQklhtftLKRi---DIGEEKQLKEV-MQLLECFQ-AKD 427 Paramecium tetr...
XP_001014520 450 --------RDNAFQISLrEfk--eSPHF-----LSQYCDDLMKq---------QltDHESNDRQIEV-NAIFDYMNtSRD 504 Tetrahymena the...
XP_001306671 454 --------VEQAWN----------AKEFrphynLVQFIHYsvv----nnLENi---PDEYKSKFPQIcKLFFDFTT-DKA 507 Trichomonas vag...
XP_001313897 378 --------ITAGWNIPAfN-----IVEN-----FVQYIDFHIKnek-------krlSKTENENFERTcARFFRYTE-DKV 431 Trichomonas vag...
CCK70086     392 --------LGDATSNFF-AddpmqSAQF-----VSLYFDVQLK----------A--SKPSKAELGNV-VMLLKFLS-EKD 443 Kazachstania na...
XP_003958060 385 --------LDTIFSRYI-NtnknqAIQF-----ICFYLDSYLRm----tQNKeD--LEKAKNNLQDC-TKLFKLLR-EKD 442 Kazachstania af...
2HYE_C       448 VFEAFYKKDLAKRLLVGKSASVDAE---KSMLSKLKH--ECGA--AFTSKLEGMFKDMELSKDIMV-HFKQHMQn---QS 516 human
Q24DT3       419 IFEAFYNKRLARRLLMNLAYSYELE---RKVLDRLRS--ECGD--QYTMKADEILKDVNESKQLNK-DFNDY-------- 482 Tetrahymena the...
A0BYN1       418 EFEQIYRKHLCVRLLDQTYSSLEVE---KDLLKKLRL--ECGS--VLTHKMETMFSDLERSSEDSQ-KFRQKLS-----Q 484 Paramecium tetr...
Q236H3       472 YFASIYMKSLAKRILYNKSLDENNE---KQIISKFKL--ECGT--VYTKKMETMFLDMQQSLEYYN-EFKQLFIknlnTK 543 Tetrahymena the...
A0CFE8       428 LLLRNYQNKLAQRILTLFDYHSDFD---KQIIDQFRK--TYGP--EHTKQLESMIKDYEQQKNEEKiTISD--------- 491 Paramecium tetr...
XP_001014520 505 EFLLHYQQALCRRLIGFTSKSMAAE---KQIVTKFKN--SVGAl-PTLNRLQNMLTDVETNE-----QYNK--------- 564 Tetrahymena the...
XP_001306671 508 VFVPLFMNYQIQRIIKNRESEQDTRaleFEIVKQLKSigASSNteDFGKHLEEIYNQVRISIDTTK-NFKATI------- 579 Trichomonas vag...
XP_001313897 432 GFCTTYEQALLQRLIKFLTKF-DAEe--RMMIETISK--EKQP--EFMKGYKDLKACIDNSAQIDD-DFKK--------- 494 Trichomonas vag...
CCK70086     444 EFVNVYKQQLSRRLLHQRTTI-DME---RYMINRIKD--EMGS--FFTLKLESMLRDVTTSSELLK-SLPEH-------- 506 Kazachstania na...
XP_003958060 443 AFENTYTQLLSKRLIQQRSAL-HME---RFMVKQIKD--NMGS--FFTSKMEGMLRDMSTSIVLSK-SFYKNF------V 507 Kazachstania af...
2HYE_C       517 DSg-pID------LTVNILTMGYWPTYTPMe-------------------VHLTPEMIKLQEV-FKAFYLGKHSGRKLQW 569 human
Q24DT3       483 LSsqgLDynkkniFSCIVVSSSAWPMKNQQl-------------------pILFEPFDKFQKE-FKKFYELKHKGVCINW 542 Tetrahymena the...
A0BYN1       485 NQrdsID------LDILVLTSEQWPITDSQp-------------------IIIHTELLLWQQQ-FTQYYQSKNSKRKLSF 538 Paramecium tetr...
Q236H3       544 SAyksLD------FDIKVLTCGNWPYKLNQfs-----------------qVKIPNQLEPYISE-FEKHYKSKFKGRKLKW 599 Tetrahymena the...
A0CFE8       492 -----IE------IQAKILQKEYWPEIRPQlnl---------------dnILILNQLKAAYREkFNSQQEK-NQLIDISW 544 Paramecium tetr...
XP_001014520 565 ------EkvqndiLKIYVLNSVAWPLKRNEle-----------------kIIFPSSFAGIIDQ-FTKQYNQTYKQRKIFW 620 Tetrahymena the...
XP_001306671 580 PSdsqVD------FIATVLNHNIVEKFATDn------------------aFKIMPFLQDLHNR-FVGFYQQNHQNSDLKI 634 Trichomonas vag...
XP_001313897 495 --------------QI-MNTKIEWPDGMREvqfspivfnknhyklyiieqTKIPEFLSPVHDR-FIQFYQEKNKSMTLML 558 Trichomonas vag...
CCK70086     507 EKq--FE------FIPQVLTMTAWPFQNlndf---------------dadLILPRELQKVKEN-LEVAYNKKYNQRVLNW 562 Kazachstania na...
XP_003958060 508 NDkekIE------FVPQVLTMTSWPFENineli-------------dendVILPPRLEELKQN-FEVTYSKKYGERVLKW 567 Kazachstania af...
2HYE_C       570 QTTLGHAVLKAeFKEG------Kk-EFQVSLFQTLVLL-MF-N--EGdGFSFEEIKmatgiedSELRRTLQSLACGK--A 636 human
Q24DT3       543 QHETSTCDIQGnYNK-------EkyIFQVQLIQGLILL-CF-NlkN--KLSYTEIHnlvqideEELKKNLVSLYAMKdtQ 611 Tetrahymena the...
A0BYN1       539 NYGLGSVSLKAtFDQN------SkkDFVCSVFQATILM-HF-Nk-QR-VYKVDELIkltnsdkEIMQYELENL------- 601 Paramecium tetr...
Q236H3       600 IYSVGKSIVKG-YYSFn----nSkkEFQVSNVQMVILL-LF-Nn-KI-KYTQQELTallqmpyEEYKLHLLPL------- 663 Tetrahymena the...
A0CFE8       545 QDQLSMVELMFrTNQe--------yKVIIGVVGGAILL-QF-Nhq-nnPQTSEQLAqsigvnnQYFLNQIKLLe-----S 608 Paramecium tetr...
XP_001014520 621 LFNEGSAEINF-TSANkkt-faGkyILRTTSYQMLILM-KM-Ne-KA-SITIQDLMdqtginkDSFDNNLKQL------- 687 Tetrahymena the...
XP_001306671 635 IPDISQLQFTFrVPKNkksanlKvyTINTDAWGGSILMaIY-Eak-etGLKKADINaitavkeDLVDAYLKMM------- 705 Trichomonas vag...
XP_001313897 559 LADTSTVQSKWrIPKNsksnkpEtyVLTTDILTSKILSyLHkNq-TE-KVSVQDIImytqeekPLVKKCIAKL------- 629 Trichomonas vag...
CCK70086     563 AHKLGLIEISYrFEKS------Sh-DLAMSFYAGLIFL-AF-E--EQdELTTEKLQqltnlpeQELVKQLVTLAVAPr-Y 630 Kazachstania na...
XP_003958060 568 AHTLGLVEIGFqFDKT------Yh-ELVMSTHAAAIFL-MF-E--DSdEVTLDMLHektgiaeQELKRHLLSMVLAPr-S 635 Kazachstania af...
2HYE_C       637 R-V---LIKs--------pKgK-EVED-GDKF------IFNGEF 660 human
Q24DT3       612 K-L---LNK----------SgEaKRVDeTDVF------EVNEAY 635 Tetrahymena thermophila SB210
A0BYN1       602 --LqfkLLI--------------QNEE-ENSL------QLNQKF 622 Paramecium tetraurelia
Q236H3       664 --VqlkILK----------SeN------NIDF------EYNDQF 683 Tetrahymena thermophila SB210
A0CFE8       609 KkL---LTRd------------------GQAY------KFNEEf 625 Paramecium tetraurelia
XP_001014520 688 --IklkILS----------CaE------EDKYtesstvQVNAQF 713 Tetrahymena thermophila SB210
XP_001306671 706 --YhmkLIAmkdk---gasNkMeDIEW-----------VLNKNF 733 Trichomonas vaginalis G3
XP_001313897 630 --LglqICVrektvkttekQqQqQLSD-TDLI------MMNKef 664 Trichomonas vaginalis G3
CCK70086     631 R-I---LLKep-------nT-K-TIRM-TDTF------RVNERY 654 Kazachstania naganishii CBS 8797
XP_003958060 636 K-I---LRKvp-------nT-R-TISP-IDRF------YINYNF 659 Kazachstania africana CBS 2517
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