Conserved Protein Domain Family
M48B_Htpx_like

?
cd07340: M48B_Htpx_like 
Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase
This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.
Statistics
?
PSSM-Id: 320699
View PSSM: cd07340
Aligned: 75 rows
Threshold Bit Score: 243.173
Threshold Setting Gi: 564723604
Created: 11-Mar-2009
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
A3CLJ7     52 IYAGVMIFQSTEVVMAMNGAREvse----qeaPELYHIVQDMAMVAQIPMPRVYIVEDpsPNAFATGskPENAAVAATTG 127 Streptococcus sang...
EAP90876   77 AIWFAIAWFSHQAIIDASTGARkvsr---tdaPELYNLLENLTISRGMPMPSLRIIETdaLNAYASGlsEKKAVITVTRG 153 Oceanicaulis sp. H...
ADU46242   73 LWIVIAYFFHQKLIDAVTGGHAvtr----aeqPRLYNLLENLCISRGIPMPKLKIMDSaaLNAFASGlnPKQYAITVTSG 148 Rhodopseudomonas p...
AEP10749   80 IWFIIAWFFNTRMVAMLSHAKPvtr----aeePALYNLLENLCIARGLPMPHLNIIETdaLNAFASGvqRSDYTVTVTRG 155 Micavibrio aerugin...
EKD66721   76 IWALISFTFYRQIIFSFSDARAitr----aenPEIYNIVENLCISRGLAVPNIGILEDdsLNAFAVGwnVKKSWIVFSRW 151 uncultured bacteri...
KFC75600   70 LAAAAWVFIGFKVNVGLIGAVTgasgvtreqnPKLYRMLENLCISRGLTVPKLSIVESeaLNAFASGvnDKQFTVTVTTG 149 Bosea sp. LC85
ACX75026   88 VWFIIAYCANTAIIRHATHAKPver----kdnLRVYNIVENLCIAGGIEMPQINIIQDsgMNAFASGidIPSFTITLTTG 163 Fibrobacter succin...
KIF25911   83 IWFIIAWFSHQAMIDAATGARKvtr----eeqPELYNLLENLCISRGITMPALRIIETpqMNAYASGltEKQYSVTVTSG 158 Scytonema millei
CRH72561   79 IWFAIAYFTNVAMIQRATGARPler----renPRVYNIVENLCMTCGMSMPQIHVVDDpqLNAFASGinDKSYTVTLTTG 154 Chlamydia trachomatis
BAU93712   79 LWLFVAFHAHQALVSGVVGARLlar----peaPGLHRLLEDLCISRGITVPALQIVDDsaLNAYATGlnPQQYAITVTTG 154 Methylobacterium p...
Feature 1                    #   #                                                            
A3CLJ7    128 ILQiMNREELEGVIGHEVSHIRNyDIRISTIAVALASAITMLsslagrmmwfgggr-----------rssndrdndsglg 196 Streptococcus sang...
EAP90876  154 LMErLDRDELEAVLAHELSHVINrDVRLLVIAVIFVGIISFTveiaarsvfygsls-----------ragggrrgrsgna 222 Oceanicaulis sp. H...
ADU46242  149 LVDrLDDAELEAVLAHELTHIKNgDVQMMVIAVIIAGVVGFFgelmfrlffqggvrigggwsgggssssssssgrkggga 228 Rhodopseudomonas p...
AEP10749  156 LLNtLQPDEVEGVLAHELTHIINhDVRLLMVCIIFTGMIGFVmqlvwssvrygly--------------mprsgnnrnng 221 Micavibrio aerugin...
EKD66721  152 ILNkLNKSEIEAVAAHELTHIINkDGLLLVTIIVFIGAIAAIweiifrtglhmwgg------------kssdgkdsgqlk 219 uncultured bacteri...
KFC75600  150 LIQtLTDDEIEAVLAHELTHIRNgDVRMMIIAVVIAGVISLIgeiifrsigrvr----------------vssddakkgs 213 Bosea sp. LC85
ACX75026  164 LIEkLDDRELSAVVGHELTHIKNrDTRLMVVCIVFVGIFATIqmvsmklmsaivrspq--------rssrrnrnsgradi 235 Fibrobacter succin...
KIF25911  159 LMQrLDRDELEAVLAHELTHIINrDVRLLVISVIFVGIFSFVaqigvramfhgava-----------rsgrsrrggggna 227 Scytonema millei
CRH72561  155 IINrLNDEELKGVVAHELTHIRNkDTRLLVVSIIFVGIISTVmslvvrmmyqtmwfgg-------svrrskdergtglsi 227 Chlamydia trachomatis
BAU93712  155 LMAaLDAREMRAVLAHELTHIRNdDVRTMMLAVVIAGLYAFVaegmaradlmra---------------paqgdgkrtga 219 Methylobacterium p...
Feature 1                                    #                                                
A3CLJ7    197 iILLIVSLIAIVLAPLAAtlv--qlAISRQREFLADASSVELTRNPqGMINALLKLDrsepmehhvddasa--------- 265 Streptococcus sang...
EAP90876  223 gVILLVAGLIVALAYGLAivi--rfALSRSREYMADAGAVELTKNPdAMISALEKISghseikdapkevr---------- 290 Oceanicaulis sp. H...
ADU46242  229 iVVVILAIVLILLAWLLSqvv--klALSRSREFLADAGSVELTKNPdAMISALRKIEnrgelpgatsavm---------- 296 Rhodopseudomonas p...
AEP10749  222 gTIIIALAILLILAIGYGaslltrfALSRRREYMADAGAVELTRNPdAMMRALQRISgrdhipavpddv----------- 290 Micavibrio aerugin...
EKD66721  220 lILILVWLALLILWYLVLplv--qlAVSRKREYLADAGSVALTKDKaSMISALQNISqdstiesikkdsisalc------ 291 uncultured bacteri...
KFC75600  214 gVAILLGVAIIAISSLLAvli--rlSLSRSREYLADAGAVELTKNPdAMISALLKIAgradidgvpsgvm---------- 281 Bosea sp. LC85
ACX75026  236 yILLILLLVFIWSSIGYVftwltrlAISRKREYVADAGGAELCGDPlALASALRKISkdpglmsvkrddiaqlyvihpde 315 Fibrobacter succin...
KIF25911  228 aVMMLIAVAIVALAWFLAiai--rfALSRKREFMADAGAVELTKNPdAMIGALEKISgnasmedapseir---------- 295 Scytonema millei
CRH72561  228 lIILFVGVICCAIAYFFTlit--rfAISRKREYMADAGGAELCGNPlALADALRKISsdpgldqvkqedvaqlf------ 299 Chlamydia trachomatis
BAU93712  220 vPAMLLGAALIVLAWVLSqai--rfALSRSREYVADAGAVELTKDPdALISALLKISgrgdlvrapsgvm---------- 287 Methylobacterium p...
Feature 1                          #           
A3CLJ7    266 --alyisdpkkegglkKLFYTHPPISERVERLR 296 Streptococcus sanguinis SK36
EAP90876  291 ---qmfidnetqasfaGLFATHPPIEKRIEALV 320 Oceanicaulis sp. HTCC2633
ADU46242  297 ----emcldnprsgfsDLFATHPSVESRVDALV 325 Rhodopseudomonas palustris DX-1
AEP10749  291 ----almcienghafmGLFATHPSIDDRIRALS 319 Micavibrio aeruginosavorus ARL-13
EKD66721  292 ienpfpratwfmnkfhEFFSTHPSVSNRIAILE 324 uncultured bacterium (gcode 4)
KFC75600  282 ----dmcfendpddfaDLFSTHPSITKRVQALV 310 Bosea sp. LC85
ACX75026  316 efdnnmglkgwvakanIMFCTHPDTPERIQLLE 348 Fibrobacter succinogenes subsp. succinogenes S85
KIF25911  296 ----emmienpksgfsGIFMTHPPIEKRIEALE 324 Scytonema millei
CRH72561  300 ivhpdqmvsgimgfmnSLFATHPDTKKRIAILE 332 Chlamydia trachomatis
BAU93712  288 ----elcfdnprsgflDLLATHPPVEDRIGAIM 316 Methylobacterium populi

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap