Conserved Protein Domain Family
M48B_HtpX_like

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cd07339: M48B_HtpX_like 
Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase
This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.
Statistics
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PSSM-Id: 320698
View PSSM: cd07339
Aligned: 46 rows
Threshold Bit Score: 194.704
Threshold Setting Gi: 388529137
Created: 25-Feb-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
ACN13267      51 SYFLTPRVPAHLIMLASGARRVSpgslPQLHGIAGTLSQRAGLT-TLPRLYYHPSaRLNAFAAGtpedPAICVSRGLLSv 129 Desulfobacteriu...
ERS83463      50 TLYLSGRVPARLVLANAGAGVLHrhqaPQLYRVMDLLYRRAGLS-QPPWLFYVPTaDLNAFAVGdardGGIAVTEGLLHc 128 Halomonas sp. PBN3
WP_035460542  57 WLPLQPGWVLRLHRAQALHYNQA----PQLYWLLEQLCQRAELAsIPRLYWLPSQePNAFTLGQgr-qTAIALSEGLLRr 131 Balneatrix alpica
WP_044225736  55 STRVSSQMIMRFHGGRPLHPQQA----PQLSRLLQQLAQRAGLP-ATPKLYYVPNnSLNAFATGskkdPAIAITHGLLSt 129 Saprospiraceae ...
WP_028875204  59 QPLAGPELVLRLYRAQPIARSAA----PELHALVERLAARAGLPrVPRLYFVDTPiVNAFSVGShn-dAAIALTSGLLAr 133 Tepidiphilus ma...
AEJ61803      49 LIYLMVRLSRDAYFIPANARPLSrweaPEVYRLVDTLSERAGIP-QAPQLYLVPSpLMNALTTGpaerPVIVVTDTLLSs 127 Spirochaeta the...
WP_013948724  70 HRGPEMQNTPRDHFAIRTLEPADa---PELFAEIDRICWRAKLPqRPRICVLIGQrAMNAYAFGgpndAIVTFTEGLLCg 146 Hyphomicrobium
WP_036567156  55 LRLLPTHWTLQIYNARRLSYQEA----PELYRVTQILSQRAGLNrVPELYWIPSRmLNAFSVGDet-rSGVGLTHGLLNt 129 Oceanospirillum...
WP_021270232  52 VFSLHAKQSSKFLLKIHNGVLLKyedvPWLFGVVDFLSAKAGLEsSPELYILNTKvPNAFTTETke-gPILAISAGLIAr 130 Bacteriovorax s...
AFK54334      52 LPGLPAGLVLRAHRARPIPYAAL----PEIHDALAALAARAGIHaRPRLCWCPARqPNAFALDDag-vPVVVITDGLLRr 126 Tistrella mobil...
Feature 1                   #   #                                                                
ACN13267     130 lnlDEIAGVMGHEISHISNnDMKVMGFAALFGLLTQFASlagql--lllfSLPLILLSDVEISLvalaLLIFAPALSTLL 207 Desulfobacteriu...
ERS83463     129 lslRQLAGVLAHEVSHLRHgDTRVMSMAATMTRLTVWGAflvql--alivMLPMVMAGELRLPWlellVVGLAPTASTLL 206 Halomonas sp. PBN3
WP_035460542 132 lnsRQLQGVLAHELAHVRQgDWRLLAWADGISRLLRGLSllgql--glilALPFWLLGQVQISWggmlLLVLLPWLSTLL 209 Balneatrix alpica
WP_044225736 130 mdlRGLSGILAHEISHIRNnDLQLKSMVKLFSRYTRFFSlfgqi--llfiNLPLFFMGEATVSWmaiaLLLLAPTLVTLM 207 Saprospiraceae ...
WP_028875204 134 ldlRQITGVLAHEVAHIAHgDIRVMSLADSLTRMTSVLSltgql--lllvNLPLLLVGAAVVNWlavgLLIFAPHIAMLV 211 Tepidiphilus ma...
AEJ61803     128 lppRELAGVLAHEIAHIRNgDLTLFRMVEIIRQFTEMVSqagwv--llvfFFPFLLFARQVQPLsfflFMVASPILSLLL 205 Spirochaeta the...
WP_013948724 147 mttKEVGAIFAHEIAHICNgDSATMSWAAQLQRAINDVAaa--------gLAPVHAFGAVKQQSslqwVLTRAPAIAELL 218 Hyphomicrobium
WP_036567156 130 lthRELVGVMAHEISHIAHnDTRLMALADIISRLNYLLAltacl--mtllLMPMALLGLVDLSLlalmLLVLTPWLSGLL 207 Oceanospirillum...
WP_021270232 131 mdkREIKGVIAHELSHIIHkDATYLKIVQGLYAFVAFLStlvhisiifflPFYLMGSFNLSTSFl--lAILIVPSILRLV 208 Bacteriovorax s...
AFK54334     127 ltpPELMAVLAHELAHIANgDLKIMRLADGLGRITGLMAwlgia--llalNLPLILLGAVTVPLaavlLLIAAPGLVGLM 204 Tistrella mobil...
Feature 1                #                                                      #            
ACN13267     208 QFTLSRTREFDADLGSAFLTGNPlMLASALNKLEvyrqhglk-----rffrlapDQGLVWLNTHPStgERIRRLMN 278 Desulfobacterium au...
ERS83463     207 QLALSRNREFTADLEAAALTRDPeGLAEALAVLEaqkglwlt----tlfgrrqlPSWLRFLQTHPAteERVGRLMA 278 Halomonas sp. PBN3
WP_035460542 210 QLALSRTREFSADMEAARLSGDPeGLAQALEALHwqpgwwqr-----llipakaEAGSAWLRTHPPtpERIKRLRA 280 Balneatrix alpica
WP_044225736 208 VQAFSRSREYDADLEAARLTGDPnALADALETLDyynkggwl----arfqsprgIKVPTILSSHPKikDRVKRLRE 279 Saprospiraceae bact...
WP_028875204 212 QLGLSRVREFDADLAAVALTDDPeGLASALMAIErvqrgwra-----wlfpgwgSPEPSWLRTHPAteERVRRLLE 282 Tepidiphilus margar...
AEJ61803     206 ALAIQRTREFQADLTAAELTGDPqGLAMALYRITsprydilgalfpfgrslrrlEREHSLFLSHPPteERIRRLLS 281 Spirochaeta thermop...
WP_013948724 219 MLALSRFREIEADAFALELTGDAkTLETALAKLEhhhralsg-----ipegyieDRLASYLRSHPVtsERIDHLRA 289 Hyphomicrobium
WP_036567156 208 QLKLSRTREFAADLQAAHLTGDPmGLASALSKIDmgerkgwq-----rilvgyqQTQPSLLRSHPAtkERIRALKQ 278 Oceanospirillum bei...
WP_021270232 209 ILALMRNREYAADLMAVNLTEDPeGLALALSKLNsmnhwvvg-----lmfpynfGRKNSLLDTHPLpkQRIQRLMA 279 Bacteriovorax sp. B...
AFK54334     205 QLALSRTREFAADLEAARLTGDPaALARALLALErsgpwe--------aifrlrHQGPGLLRTHPAtaERVRRLAE 272 Tistrella mobilis K...

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