4AW6


Conserved Protein Domain Family
M48A_Ste24p

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cd07330: M48A_Ste24p 
Click on image for an interactive view with Cn3D
Peptidase M48 CaaX prenyl protease type 1, an integral membrane, Zn-dependent protein
This family of M48 CaaX prenyl protease 1-like family includes a number of well characterized genes such as those found in Taenia solium metacestode (TsSte24p), Arabidopsis (AtSte24), yeast Ste24p and human (Hs Ste24p) as well as several uncharacterized genes such as YhfN, some of which also containing tetratricopeptide (TPR) repeats. All members of this family contain the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. They are thought to be intimately associated with the endoplasmic reticulum (ER), regardless of whether their genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. The gene ZmpSte24, also known as FACE-1 in humans, a member of this family, is involved in the post-translational processing of prelamin A to mature lamin A, a major component of the nuclear envelope. ZmpSte24 deficiency causes an accumulation of prelamin A leading to lipodystrophy and other disease phenotypes while mutations in the protein lead to diseases of lamin processing (laminopathies), such as premature aging disease progeria and metabolic disorders. Some of these mutations map to the peptide-binding site.
Statistics
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PSSM-Id: 320689
View PSSM: cd07330
Aligned: 6 rows
Threshold Bit Score: 253.135
Threshold Setting Gi: 543112037
Created: 11-Mar-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteputative active
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:Human nuclear membrane zinc metalloprotease Zmpste24p binds zinc; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
4AW6_A       118 YEITQSLVFLLLATLFSALAGLPWSLYNTFVIEEKHGFnq---qTLGFFMKDAIKKFVVTQCILLPVSSLLLYIikig-- 192 human
ACN14883      80 FPTLEALVFLLVFLGYLVIVWTSAWGVQKQFFSGTVSKks---fVLSNISFSLPALLPWFLLSIMADFIQILPFegprtf 156 Desulfobacteriu...
ERJ19637      83 YGEAGALVFVAVFAIADQLLCEVRAWARWWFAERAGGMsrsgmaTVALDSGRRVALNTVIATLAAAWVLWPFSFwafgwa 162 Salinisphaera s...
EHY30169     101 NPLVAQWLVLAAVTFTAALIEFPFGWFAHFRVQERFGYml---eDRRLWMLREIRRTFAGWLVSLPVLALLIVLlehagg 177 Sutterella parv...
EKB32080     101 PGIPADWVLISLIVLLMLLIELPFGWWARYRVKERYGYmr---ePRMRWLSRTLSEALWGWLVFMPVSAALLTIfeyagg 177 Sutterella wads...
WP_016474977 101 NTLLVQWSLLVSIMGLMVVVSLPLEWLIRYRLRERFGYqr---rSRKEWFKRTVGISTAGLAAALPATALLLILcevtgp 177 Sutterella wads...
Feature 1                                                                                        
4AW6_A       193 --gdyfFIYAWLFTLVVSLVLVTIYADyiaplfdkftplpegkLKEEIEVMAKsid-----fplTKVYVVegskr--ssh 263 human
ACN14883     157 latplgEILYVIFFLFAVASFGPFLIQklwgcs----sldpgpTRERIESLCNlagig--cadiLKWELFggsm----it 226 Desulfobacteriu...
ERJ19637     163 wpisggLLIAGAALLFWARPNLIAPLFerfkp------leageLRQRLEAMMQrcgth--leqvLVVDTSrrs-----rv 229 Salinisphaera s...
EHY30169     178 -awwwiGWVFFLLYLFWRWKFSNTVALfwkrrsq---pmadrkTAEMILAYMRhegfvvddvevMTKPLSwa-------h 246 Sutterella parv...
EKB32080     178 -dwwklAWGVWLVYLLWRWKLSSVYGVfwkrrsr---pyanaeTREAVRESLHrq-------giTMTEMVvmtrpaswdh 246 Sutterella wads...
WP_016474977 178 -ywwllVWMLYLAWLFWRWRLSLMRGKlwsrasr---piqneaLRRKVRSLLAeegf---rmedLVIMTRppaw----ky 246 Sutterella wads...
Feature 1                                                                               #   #    
4AW6_A       264 sNAYFYgffknkRIVLFDTLLeeysvlnkdiqedsgmeprneeegnseeikakvknkkqgcknEEVLAVLGHELGHWKLg 343 human
ACN14883     227 aGVMGLvs--rfRYILVTPALvsl------------------------------------mtpREVDAVIAHEIGHVKKh 268 Desulfobacteriu...
ERJ19637     230 aNAYFTglg-rsKRVVLSDTLiaq------------------------------------lsaAELEAVMAHELGHYRC- 271 Salinisphaera s...
EHY30169     247 sHLVIPgwgkkrRVVVFAHAAqrl-------------------------------------epDELLALIAHDVGHVKH- 288 Sutterella parv...
EKB32080     247 sNIVLSgwglrrRVIVFAHVAhll-------------------------------------rkDEIVALAAHEAAHVRHf 289 Sutterella wads...
WP_016474977 247 aHVLLPgsgelrRVVVFADTAakl-------------------------------------teDELLAVIASQAARIKFh 289 Sutterella wads...
Feature 1                                                                                      # 
4AW6_A       344 HTVKNIIISQMNSFLCFFLFavligrkelfaafgfyd-------sqptliglliifqfifsPYNEVLSFCLTVLSRRFEF 416 human
ACN14883     269 HIHFYLFFFAGYIACVYALFdpllvlvyamdplswfvsf---vgmeqetfstlvfslililLFILYFRFVFGFFMRNFER 345 Desulfobacteriu...
ERJ19637     272 GHLQRFYASQAALLFGAYLAlgavaammnlspa---------------paelvvaaylllpALGWPLQFWQSARRRRYEY 336 Salinisphaera s...
EHY30169     289 LHLFLRAAVYAVTGWLVFRFagwgaehveffegfgyapavsflqdgtragyvlaiavtafpILYYPLRPAVNLFARLMQY 368 Sutterella parv...
EKB32080     290 HGVLRLLINVAVSYIFCWLAgwgathvqffegfnyspmlt-ldmpgthagsvcavalvvfpMLLYPLSPLLNLAARLMQY 368 Sutterella wads...
WP_016474977 290 HGPWRIALSAAGGFITCAVLgwaantpvffeglgfspslt-vmqpgthagfamaaaviafpIVFFPLRALNNFIIRQLRY 368 Sutterella wads...
Feature 1                                                   #            
4AW6_A       417 QADAFAKKLgka-kdLYSALIKLNkdnlgfpvsdWLFSMWHYSHPPllERLQALKT 471 human
ACN14883     346 QADTYVFSLlgsgrsLIDTFYKIArfs----rtsPDRPNWHHFNIT--QRINFLER 395 Desulfobacterium autotrophicum HRM2
ERJ19637     337 EADAYAAEHada-aaLISALEKLLannltaptmdRWYAALFATHPPgaSRLARLHA 391 Salinisphaera shabanensis E1L3A
EHY30169     369 DADEYAAKAvst-daLVRALVKLHrdykqtltpsRLYSLFHYSRPHagMRVAHLLW 423 Sutterella parvirubra YIT 11816
EKB32080     369 DADLHAARIagl-dpMISALVKLHkdtttslspsLVYSLFHYKRPHpgMRVANLQR 423 Sutterella wadsworthensis 2_1_59BFAA
WP_016474977 369 AADRCGAAKmgg-dtLARALAKLHrdysntltpsRFYSVLHYDHPHaaMRVAHLLK 423 Sutterella wadsworthensis

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