2ECT


Conserved Protein Domain Family
RING-H2_RNF126

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cd16801: RING-H2_RNF126 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger protein 126 (RNF126) and similar proteins
RNF126 is a Bag6-dependent E3 ubiquitin ligase that is involved in the mislocalized protein (MLP) pathway of quality control. It regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor (CI-MPR). Moreover, RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation, and could be a novel therapeutic target in breast and prostate cancers. It is also able to ubiquitylate cytidine deaminase (AID), a poorly soluble protein that is essential for antibody diversification. In addition, RNF126 and the related protein, RNF115 associate with the epidermal growth factor receptor (EGFR) and promote ubiquitylation of EGFR, suggesting they play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. RNF126 contains an N-terminal BCA2 Zinc-finger domain (BZF), the AKT-phosphorylation sites, and the C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319715
View PSSM: cd16801
Aligned: 8 rows
Threshold Bit Score: 97.3261
Threshold Setting Gi: 168176990
Created: 24-Mar-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-H2 finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2ECT; Mus musculus RNF126 binds two Zn2+ ions through its RING-H2 finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #              # #  #  #          #  #  
2ECT_A        17 ECPVCKEDYalGESVRQLPCNHLFHDSCIVPWLEqHDSCPVCRK 60  house mouse
NP_001076486 225 ECPVCKEDYsaGENVRQLPCNHLFHNDCIVPWLEqHDTCPVCRK 268 zebrafish
Q6IRP0       227 ECPVCKEDYtvGESVRQLPCNHLFHNDCIIPWLEqHDTCPVCRK 270 African clawed frog
NP_001006338 229 ECPVCKEDYtvGENVRQLPCNHLFHNSCIVPWLEqHDTCPVCRK 272 chicken
XP_005992002 230 ECPVCKEDYaiGETVRQLPCNHLFHNDCIVPWLEqHDTCPVCRK 273 coelacanth
XP_007897125 242 ECPVCKEDYgvGENVRQLPCNHLFHNDCIVPWLEmHDTCPVCRK 285 elephant shark
Q7T0Q3       227 ECPVCKEDYtvGECVRQLPCNHLFHNDCIIPWLEqHDTCPVCRK 270 African clawed frog
Q9BV68       228 ECPVCKDDYalGERVRQLPCNHLFHDGCIVPWLEqHDSCPVCRK 271 human

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