Conserved Protein Domain Family
RING-HC_TRIM3

?
cd16768: RING-HC_TRIM3 
RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
TRIM3, also known as brain-expressed RING finger protein (BERP), RING finger protein 97 (RNF97), or RING finger protein 22 (RNF22), is an E3 ubiquitin-protein ligase involved in the pathogenesis of various cancers. It functions as a tumor suppressor that regulates asymmetric cell division in glioblastoma. It binds to the cdk inhibitor p21(WAF1/CIP1) and regulates its availability that promotes cyclin D1-cdk4 nuclear accumulation. Moreover, TRIM3 plays an important role in the central nervous system (CNS). It corresponds to gene BERP (brain-expressed RING finger protein), a unique p53-regulated gene that modulates seizure susceptibility and GABAAR cell surface expression. Furthermore, TRIM3 mediates activity-dependent turnover of postsynaptic density (PSD) scaffold proteins GKAP/SAPAP1 and is a negative regulator of dendritic spine morphology. In addition, TRIM3 may be involved in vesicular trafficking via its association with the cytoskeleton-associated-recycling or transport (CART) complex that is necessary for efficient transferrin receptor recycling, but not for epidermal growth factor receptor (EGFR) degradation. It also regulates the motility of the kinesin superfamily protein KIF21B. TRIM3 belongs to the C-VII subclass of TRIM (tripartite motif)-NHL family that is defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil domain, as well as a NHL (named after proteins NCL-1, HT2A and Lin-41 that contain repeats folded into a six-bladed beta propeller) repeat domain positioned C-terminal to the RBCC domain.
Statistics
?
PSSM-Id: 319682
View PSSM: cd16768
Aligned: 5 rows
Threshold Bit Score: 106.243
Threshold Setting Gi: 148229453
Created: 28-Jul-2013
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #           # #  #  #             #  # 
O75382        19 FLVCSICLDRYqcPKVLPCLHTFCERCLQNYIPAQSlTLSCPVCR 63  human
XP_422922     19 FLVCSICLDRYrnPKVLPCLHTFCERCLQNYIPPQSlTLSCPVCR 63  chicken
NP_001073637  20 FLVCSICLDHYhnPKVLPCLHTFCERCLQNYIPPQSlTLSCPVCR 64  zebrafish
NP_001088374  13 FLVCSICLERYhvPKVLPCLHTFCERCLQSYIPPQSlTLSCPVCR 57  African clawed frog
XP_006004887  19 FLVCSICLDRYhnPKVLPCLHTFCEKCLQNYIPPQSlTLSCPVCR 63  coelacanth

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap