Conserved Protein Domain Family
RING-HC_TRIM59_C-V

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cd16763: RING-HC_TRIM59_C-V 
RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins
TRIM59, also known as RING finger protein 104 (RNF104) or tumor suppressor TSBF-1, is a putative E3 ubiquitin-protein ligase that functions as a novel multiple cancer biomarker for immunohistochemical detection of early tumorigenesis. It is upregulated in gastric cancer and promotes gastric carcinogenesis by interacting with and targeting the P53 tumor suppressor for its ubiquitination and degradation. It also acts as a novel accessory molecule involved in cytotoxicity of BCG-activated macrophages (BAM). Moreover, TRIM59 may serve as a multifunctional regulator for innate immune signaling pathways. It interacts with ECSIT and negatively regulates nuclear factor-kappaB (NF- kappa B) and interferon regulatory factor (IRF)-3/7-mediated signal pathways. TRIM59 belongs to the C-V subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region. In addition, TRIM59 contains a C-terminal transmembrane domain.
Statistics
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PSSM-Id: 319677
View PSSM: cd16763
Aligned: 5 rows
Threshold Bit Score: 111.1
Threshold Setting Gi: 301607377
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens transcription factor PML (1BOR) binds two Zn2+ ions through its RING-HC finger.
  • Citation:PMID 8317827
  • Citation:PMID 7729428

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #           # #  #  #                       #  # 
Q8IWR1         5 EEELTCPICYSiFEDPRVLPCSHTFCRNCLENILqasg-nfyIWRPLRIPLKCPNCR 60  human
Q5ZMD4         5 EEELTCSICYSlFEDPRVLPCSHTFCRSCLEGVIqlss-nfsIWRPLRVPLKCPNCR 60  chicken
CAF97398       5 EEDLTCSVCYSlFSDPRVLPCSHTFCKNCLDNLLkvsndnssLWRPLRPPLKCPNCR 61  spotted green pufferfish
XP_002933282   5 EDELTCSVCYNiFDDPRILPCSHTFCRNCLEKVIhss--gsgLWRTSAAWLKCPSCR 59  western clawed frog
XP_007886743  22 EEDLTCSVCYSiFEDPRVLPCSHTFCRTCLENIIqgsg-nfsVWRPLRFPLKCPTCR 77  elephant shark

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