Conserved Protein Domain Family
RING-HC_MuRF3

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cd16761: RING-HC_MuRF3 
RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
MuRF-3, also known as tripartite motif-containing protein 54 (TRIM54), or RING finger protein 30 (RNF30), is an E3 ubiquitin-protein ligase in ubiquitin-mediated muscle protein turnover. It is ubiquitously detected in all fibre types, and is developmentally upregulated, associates with microtubules, the sarcomeric M-line (this report) and Z-line, and is required for microtubule stability and myogenesis. It associates with glutamylated microtubules during skeletal muscle development, and is required for skeletal myoblast differentiation and development of cellular microtubular networks. MuRF-3 controls the degradation of four-and-a-half LIM domain (FHL2) and gamma-filamin and is required for maintenance of ventricular integrity after myocardial infarction (MI). MuRF-3 belongs to the C-II subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox2, and a coiled coil region, as well as a COS (carboxyl-terminal subgroup one signature) box, and an acidic residue-rich (AR) domain. It also harbors a MURF family-specific conserved box (MFC) between its RING-HC finger and Bbox domains.
Statistics
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PSSM-Id: 319675
View PSSM: cd16761
Aligned: 5 rows
Threshold Bit Score: 136.32
Threshold Setting Gi: 678210137
Created: 23-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF146 (4QPL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #  #            # #  #  #                           #  # 
Q9BYV2        24 LICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGsttvssGGRFRCPSCR 82  human
NP_001085095  24 LICPICLEMFTKPVVILPCQHNLCRKCANDIFQASNPLWQSRGsstvssGGRFRCPSCR 82  African clawed frog
NP_001038490  24 LICPICLEIFSKPVVILPCQHNLCRKCANDVFQASNPLWQNRAsttvstGGRFRCPSCR 82  zebrafish
XP_005999292  24 LICPICLEMFTKPVVILPCQHNLCRKCANDIFQASNPLWQSRGtstmssGGRFRCPSCR 82  coelacanth
KFV77116      15 LICPICLEMFTKPVVILPCQHNLCRKCANDVFQASNPLWQSRGssavpsGGRFRCPSCR 73  downy woodpecker

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