Conserved Protein Domain Family
RING-HC_MuRF1

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cd16759: RING-HC_MuRF1 
RING finger, HC subclass, found in muscle-specific RING finger protein 1 (MuRF-1) and similar proteins
MuRF-1, also known as tripartite motif-containing protein 63 (TRIM63), RING finger protein 28 (RNF28), iris RING finger protein, or striated muscle RING zinc finger, is an E3 ubiquitin-protein ligase in ubiquitin-mediated muscle protein turnover. It is predominantly fast (type II) fibre-associated in skeletal muscle and can bind to many myofibrillar proteins, including titin, nebulin, the nebulin-related protein NRAP, troponin-I (TnI), troponin-T (TnT), myosin light chain 2 (MLC-2), myotilin, and T-cap. The early and robust upregulation of MuRF-1 is triggered by disuse, denervation, starvation, sepsis, or steroid administration resulting in skeletal muscle atrophy. It also plays a role in maintaining titin M-line integrity. It associates with the periphery of the M-line lattice and may be involved in the regulation of the titin kinase domain. It also participates in muscle stress response pathways and gene expression. MuRF-1 belongs to the C-II subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox2, and a coiled coil region, as well as a COS (carboxyl-terminal subgroup one signature) box, and an acidic residue-rich (AR) domain. It also harbors a MURF family-specific conserved box (MFC) between its RING-HC finger and Bbox domains.
Statistics
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PSSM-Id: 319673
View PSSM: cd16759
Aligned: 4 rows
Threshold Bit Score: 136.697
Threshold Setting Gi: 556970985
Created: 24-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF146 (4QPL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #            # #  #  #                           #  #  
Q969Q1        18 EKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWTSRGssvsmSGGRFRCPTCRH 80  human
XP_007894938  21 EKQLICPICLEMFSKPVVILPCQHNLCRKCANDMFQASNPYWQTRGgsmlgSGGRFRCPSCRH 83  elephant shark
EMP25337      18 EKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQAANPYWQSRGtp--lSGGRFRCPSCRH 78  green sea turtle
XP_005993975  18 EKQLICPICLEMFTKPVVILPCQHNLCRKCANDVFQAANPYWQSRGts--iSGGRFRCPSCRH 78  coelacanth

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