Conserved Protein Domain Family

cd16745: RING-HC_AtRMA_like 
RING finger, HC subclass, found in Arabidopsis thaliana RING membrane-anchor proteins (AtRMAs) and similar proteins
AtRMAs, including AtRma1, AtRma2, and AtRma3, are endoplasmic reticulum (ER)-localized Arabidopsis homologs of human outer membrane of the ER-anchor E3 ubiquitin-protein ligase, RING finger protein 5 (RNF5). AtRMAs possess E3 ubiquitin ligase activity, and may play a role in the growth and development of Arabidopsis. The AtRMA1 and AtRMA3 genes are predominantly expressed in major tissues, such as cotyledons, leaves, shoot-root junction, roots, and anthers, while AtRMA2 expression is restricted to the root tips and leaf hydathodes. AtRma1 probably functions with the Ubc4/5 subfamily of E2. AtRma2 is likely involved in the cellular regulation of ABP1 expression levels through interacting with auxin binding protein 1 (ABP1). AtRMA proteins contain an N-terminal C3HC4-type RING-HC finger and a trans-membrane-anchoring domain in their extreme C-terminal region.
PSSM-Id: 319659
View PSSM: cd16745
Aligned: 24 rows
Threshold Bit Score: 78.1148
Threshold Setting Gi: 224014001
Created: 9-Feb-2016
Updated: 18-Aug-2016
Aligned Rows:
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
  • Comment:Based on the structural evidence that Homo sapiens BRCA1 (1JM7) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1          #  #            # #  #  #                    #  #  
Q8GUK7        42 FDCNICLDTa-hDPVVTLCGHLFCWPCIYKWLhvqlssvsvdqhqnnCPVCKS 93  thale cress
EGD77884      82 FSCNICLDAv-sDPVVTRCGHLFCWPCLHEWLrrk----------pdCPVCKA 123 Salpingoeca sp. ATCC50818
EAN78052       6 FSCAICYEVa-sEPVVTRCGHLFCWRCLSRWLhpprs-----avnteCPVCRG 52  Trypanosoma brucei brucei TREU927
EIE24164      33 FECNICYDLa-qSPVVTMCGHLYCWPCLYRWMqvqt-------hcrvCPVCKA 77  Coccomyxa sp. C-169
BAM79379      73 FDCSICFEVpleDPVVTMCGHLFCWSCLHRWMaqh----------atCPVCKS 115 Cyanidioschyzon merolae strain 10D
EUT89352     284 FECNICFDDv-rDPVVTKCGHLFCWLCLSAWIkkn----------ndCPVCKA 325 Plasmodium falciparum Santa Lucia
XP_002764849  39 FECNICFDQa-sEPVVTRCGHLFCWSCLDQWLdrs----------geCPVCKA 80  Perkinsus marinus ATCC 50983
ETO14215      49 FDCNICFDVc-sDPVVTCCGHLYCWQCLEKWLdrs----------qtCPVCQG 90  Reticulomyxa filosa
KPV77994      67 YSCHICLDVp-sEPVVTPCGHLHCWPCMHEWLvesn--------graCPVCKA 110 Rhodotorula graminis WP1
EPR61454     347 FECNICFDEa-tDPVVTRCGHLFCWTCLHAWLrrg---------tyeCPVCKA 389 Toxoplasma gondii GT1

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