Conserved Protein Domain Family
RING-H2_RNF122

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cd16676: RING-H2_RNF122 
RING finger, H2 subclass, found in RING finger protein 122 (RNF122) and similar proteins
RNF122 is a RING finger protein associated with HEK 293T cell viability. It is localized to the endoplasmic reticulum (ER) and the Golgi apparatus, and overexpressed in anaplastic thyroid cancer cells. RNF122 functions as an E3 ubiquitin ligase that can ubiquitinate itself and undergoes degradation through its RING finger in a proteasome-dependent manner. It interacts with calcium-modulating cyclophilin ligand (CAML), which is not a substrate, but a stabilizer of RNF122. RNF122 contains an N-terminal transmembrane domain and a C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319590
View PSSM: cd16676
Aligned: 4 rows
Threshold Bit Score: 85.458
Threshold Setting Gi: 591383867
Created: 24-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF24 (2EP4) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #  #              # #  #  #          #  #    
Q9H9V4        91 QTCAVCLEDFKgKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPI 137 human
XP_007066392  91 QTCAVCLEDFKvKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPI 137 green sea turtle
XP_005988286 316 QTCAVCLEDFKvKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKQI 362 coelacanth
XP_007892425  67 QTCAVCLEDFKtKEELGVLPCKHAFHRKCLVKWLEIRCVCPMCNKPI 113 elephant shark

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