Conserved Protein Domain Family
mRING-HC-C3HC3D_Nrdp1

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cd16634: mRING-HC-C3HC3D_Nrdp1 
Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
Nrdp1 (referred to as FLRF in mice), also known as RING finger protein 41 (RNF41), is an E3 ubiquitin-protein ligase that plays a critical role in the regulation of cell growth and apoptosis, inflammation and production of reactive oxygen species (ROS), as well as in doxorubicin (DOX)-induced cardiac injury. It promoten and degradation of the epidermal growth factor receptor (EGFR/ErbB) family member, ErbB3, which is independent of growth factor stimulation. It also promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein beta (C/EBPbeta) via Lys-63-linked ubiquitination. Moreover, Nrdp1 interacts with and modulates activity of Parkin, a causative protein for early onset recessive juvenile parkinsonism (AR-JP). It also interacts with ubiquitin-specific protease 8 (USP8), which is involved in trafficking of various transmembrane proteins. Furthermore, Nrdp1 inhibits basal lysosomal degradation and enhances ectodomain shedding of JAK2-associated cytokine receptors. Its phosphorylation by the kinase Par-1b (also known as MARK2) is required for epithelial cell polarity. Nrdp1 contains an N-terminal modified C3HC3D-type RING-HC finger required for enhancing ErbB3 degradation, a B-box, a coiled-coil domain responsible for Nrdp1 oligomerization, and a C-terminal ErbB3-binding domain.
Statistics
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PSSM-Id: 319548
View PSSM: cd16634
Aligned: 17 rows
Threshold Bit Score: 82.0874
Threshold Setting Gi: 761908024
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitemodified
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens LNX2 (5DIN) binds two Zn2+ ions through its modified RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #            # #  #  #          #  # 
Q9H4P4        15 DLICPICSGVLEEPvQAPHCEHAFCNACITQWFsqQQTCPVDR 57  human
CBY11505      16 ELICPICRGVLENViYAPKCEHAFCSDCIHEWLtnQQTCPLDR 58  Oikopleura dioica
EFX81716      15 ELLCPICSSVLENPlQAPNCEHAFCSACIHEWLsrQPTCPVDR 57  common water flea
EKC25754      15 ELVCPICSGVLEEPlQAPQCEHAFCGACIQEWLtrQPTCPVDR 57  Pacific oyster
NP_648816     15 ELTCPICSGVLEDPlQAVMCEHAFCRGCINEWLtrQPTCPVDR 57  fruit fly
ELU17470      15 ELVCPICSGVLEEPlQAPNCEHAFCGGCINEWLtrQPTCPVDR 57  Capitella sp. I Grassle & Grassle, 1976
EEN54442      15 ELLCPICGGVLEEPvQAPQCEHAFCTACIQEWLsrQHTCPVDR 57  Florida lancelet
EEC15769      15 ELICPVCSGVLEEPlQAPQCEHAFCQGCIRQWLsrQQTCPVDR 57  black-legged tick
XP_006815010  15 ELVCPICSGVLEEPvQAPQCEHAFCTACIQEWLsrQHTCPVDR 57  Saccoglossus kowalevskii
XP_780194     15 ELICPICSAVLEDPqQAPECEHAFCSTCIQEWLsrQQTCPVDR 57  purple sea urchin

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